Selection of sucrose concentration depends on the effort required to obtain it: studies using tetrabenazine, D1, D2, and D3 receptor antagonists
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Altres documents de l'autoria: Pardo Andrés, Marta; López Cruz, Laura; San Miguel Segura, Noemí; Salamone, John; Correa, Merce
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Selection of sucrose concentration depends on the effort required to obtain it: studies using tetrabenazine, D1, D2, and D3 receptor antagonistsAutoria
Data de publicació
2015Editor
Springer VerlagISSN
1432-2072; 0033-3158Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://link.springer.com/article/10.1007/s00213-015-3872-7Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Rationale Low doses of dopamine (DA) antagonists and accumbens
DA depletions reduce food-reinforced instrumental
behavior but do not impair primary food motivation, causing
animals to reallocate behavior away from ... [+]
Rationale Low doses of dopamine (DA) antagonists and accumbens
DA depletions reduce food-reinforced instrumental
behavior but do not impair primary food motivation, causing
animals to reallocate behavior away from food-reinforced
tasks with high response requirements and select less effortful
alternatives. However, it is uncertain if this same pattern of
effects would occur if sucrose was used as the reinforcer.
Objectives These experiments studied the impact of DA depletion
and antagonism on performance of an effort-related
choice task using sucrose as the reinforcer, as well as sucrose
consumption, preference, and taste reactivity tests.
Methods The effects of DA manipulations were assessed
using a task in which rats chose between lever pressing on a
fixed ratio 7 schedule for 5.0 % sucrose versus freely consuming
a less concentrated solution (0.3 %).
Results The DA depleting agent tetrabenazine shifted effortrelated
choice, decreasing lever pressing for 5.0 % sucrose but
increasing intake of the concurrently available 0.3 % sucrose.
Tetrabenazine did not affect sucrose appetitive taste reactivity,
or sucrose consumption or preference, in free consumption
tests. The D1 antagonist ecopipam and the D2 antagonist haloperidol
also shifted choice behavior at doses that did not alter
sucrose consumption or preference. In contrast, sucrose preexposure
reduced consumption across all conditions. D3 antagonism
had no effects.
Conclusions D1 and D2 receptor blockade and DA depletion
reduce the tendency to work for sucrose under
conditions that leave fundamental aspects of sucrose
motivation (intake, preference, hedonic reactivity) intact.
These findings have implications for studies
employing sucrose intake or preference in animal
models of depression. [-]
Publicat a
Psychopharmacology (2015) 232:2377–2391Drets d'accés
© Springer-Verlag Berlin Heidelberg 2015
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