Selection of sucrose concentration depends on the effort required to obtain it: studies using tetrabenazine, D1, D2, and D3 receptor antagonists
Impacto
Scholar |
Otros documentos de la autoría: Pardo Andrés, Marta; López Cruz, Laura; San Miguel Segura, Noemí; Salamone, John; Correa, Merce
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
comunitat-uji-handle4:
INVESTIGACIONEste recurso está restringido
http://dx.doi.org/10.1007/s00213-015-3872-7 |
Metadatos
Título
Selection of sucrose concentration depends on the effort required to obtain it: studies using tetrabenazine, D1, D2, and D3 receptor antagonistsAutoría
Fecha de publicación
2015Editor
Springer VerlagISSN
1432-2072; 0033-3158Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://link.springer.com/article/10.1007/s00213-015-3872-7Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Rationale Low doses of dopamine (DA) antagonists and accumbens
DA depletions reduce food-reinforced instrumental
behavior but do not impair primary food motivation, causing
animals to reallocate behavior away from ... [+]
Rationale Low doses of dopamine (DA) antagonists and accumbens
DA depletions reduce food-reinforced instrumental
behavior but do not impair primary food motivation, causing
animals to reallocate behavior away from food-reinforced
tasks with high response requirements and select less effortful
alternatives. However, it is uncertain if this same pattern of
effects would occur if sucrose was used as the reinforcer.
Objectives These experiments studied the impact of DA depletion
and antagonism on performance of an effort-related
choice task using sucrose as the reinforcer, as well as sucrose
consumption, preference, and taste reactivity tests.
Methods The effects of DA manipulations were assessed
using a task in which rats chose between lever pressing on a
fixed ratio 7 schedule for 5.0 % sucrose versus freely consuming
a less concentrated solution (0.3 %).
Results The DA depleting agent tetrabenazine shifted effortrelated
choice, decreasing lever pressing for 5.0 % sucrose but
increasing intake of the concurrently available 0.3 % sucrose.
Tetrabenazine did not affect sucrose appetitive taste reactivity,
or sucrose consumption or preference, in free consumption
tests. The D1 antagonist ecopipam and the D2 antagonist haloperidol
also shifted choice behavior at doses that did not alter
sucrose consumption or preference. In contrast, sucrose preexposure
reduced consumption across all conditions. D3 antagonism
had no effects.
Conclusions D1 and D2 receptor blockade and DA depletion
reduce the tendency to work for sucrose under
conditions that leave fundamental aspects of sucrose
motivation (intake, preference, hedonic reactivity) intact.
These findings have implications for studies
employing sucrose intake or preference in animal
models of depression. [-]
Publicado en
Psychopharmacology (2015) 232:2377–2391Derechos de acceso
© Springer-Verlag Berlin Heidelberg 2015
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
Aparece en las colecciones
- PSB_Articles [1302]