On the different sources of cooperativity in pH titrating sites of a membrane protein channel
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http://dx.doi.org/10.1140/epje/i2016-16029-2 |
Metadatos
Título
On the different sources of cooperativity in pH titrating sites of a membrane protein channelFecha de publicación
2016Editor
EDP Sciences; Società Italiana di Fisica; Springer-VerlagISSN
1292-8941; 1292-895XCita bibliográfica
ALCARAZ, Antonio; QUERALT-MARTÍN, María. On the different sources of cooperativity in pH titrating sites of a membrane protein channel. The European Physical Journal E, 2016, vol. 39, no 3, p. 1-6.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://link.springer.com/article/10.1140%2Fepje%2Fi2016-16029-2Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Cooperative interactions play a central role in the regulation of protein functions. Here we show that in multi-site systems like ion channels the application of the Hill formalism could require a combination of ... [+]
Cooperative interactions play a central role in the regulation of protein functions. Here we show that in multi-site systems like ion channels the application of the Hill formalism could require a combination of different experiments, even involving site-directed mutagenesis, to identify the different sources of cooperativity and to discriminate between genuine and apparent cooperativity. We discuss the implications for the channel function in the bacterial porins PorA (N. meningitidis) and OmpF (E. coli) and the viroporin SARS-CoV E. [-]
Publicado en
The European Physical Journal E, 2016, vol. 39, no 3Derechos de acceso
© EDP Sciences / Società Italiana di Fisica / Springer-Verlag
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