Gray matter atrophy is associated with funcional connectivity reorganization during the Pasat Auditory Serial Addition Test (PASAT) execution in Multiple Sclerosis (MS)
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Otros documentos de la autoría: Baltruschat, Sabina Anna; Ventura Campos, Mercedes; Cruz Gómez, Álvaro Javier; Belenguer Benavides, Antonio; Forn, Cristina
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http://dx.doi.org/10.1016/j.neurad.2015.02.006 |
Metadatos
Título
Gray matter atrophy is associated with funcional connectivity reorganization during the Pasat Auditory Serial Addition Test (PASAT) execution in Multiple Sclerosis (MS)Autoría
Fecha de publicación
2015-06Editor
ElsevierCita bibliográfica
BALTRUSCHAT, Sabina Anna, et al. Gray matter atrophy is associated with functional connectivity reorganization during the Paced Auditory Serial Addition Test (PASAT) execution in Multiple Sclerosis (MS). Journal of Neuroradiology, 2015, vol. 42, no 3, p. 141-149.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0150986115000486Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background and purpose:
We explored the relationship between gray matter atrophy and reorganization of functional connectivity in multiple sclerosis patients during execution of the Paced Auditory Serial Addition ... [+]
Background and purpose:
We explored the relationship between gray matter atrophy and reorganization of functional connectivity in multiple sclerosis patients during execution of the Paced Auditory Serial Addition Test (PASAT).
Materials and methods:
Seventeen patients and 15 healthy controls were selected for the study. Atrophy was determined using voxel-based morphometry, and atrophy-related connectivity changes were assessed using psychophysiological interaction analysis. Group differences, and correlations with PASAT performance and radiological variables were also examined.
Results:
Gray matter atrophy in MS patients was circumscribed to the bilateral posterior cingulate gyrus/precuneus. Compared with controls, patients showed stronger connectivity between the left posterior cingulate gyrus/precuneus, and the left middle temporal gyrus and left cerebellum. A regression analysis in controls showed a negative correlation between PASAT scores and functional connectivity between: (1) the left posterior cingulate gyrus/precuneus, and left pre/postcentral gyri and left occipital gyrus, and (2) the right posterior cingulate gyrus/precuneus, and bilateral cerebellum and left pre/postcentral gyri. Patients showed a negative correlation between brain parenchymal fraction and functional connectivity between the left posterior cingulate gyrus/precuneus and left cerebellum.
Conclusion:
Patients with early MS and little brain damage presented more connectivity during PASAT execution, which may be interpreted as compensatory processes that help preserve cognitive functions. [-]
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Journal of Neuroradiology Volume 42, Issue 3, June 2015Derechos de acceso
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2015
Elsevier
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