Childhood trauma and the rs1360780 SNP of FKBP5 gene in psychosis: a replication in two general population samples
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Other documents of the author: Alemany, Silvia; Moya, Jorge; Ibáñez, Manuel I; Villa Martín, Elena; Mezquita, Laura; Ortet, Generós; Gastó, Cristóbal; Fañanás Saura, Lourdes; Arias, Barbara
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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INVESTIGACIONMetadata
Title
Childhood trauma and the rs1360780 SNP of FKBP5 gene in psychosis: a replication in two general population samplesAuthor (s)
Date
2016Publisher
Cambridge University PressISSN
0033-2917; 1469-8978Type
info:eu-repo/semantics/articlePublisher version
http://search.proquest.com/docview/1746627724/fulltextPDF/83177BEF27C7485FPQ/1?a ...Version
info:eu-repo/semantics/submittedVersionSubject
Abstract
FKBP5 gene interacts with childhood trauma in the risk for several stress-related psychiatric disorders including subclinical psychosis. The present study examined whether variation at the rs1360780 SNP of FKBP5 gene ... [+]
FKBP5 gene interacts with childhood trauma in the risk for several stress-related psychiatric disorders including subclinical psychosis. The present study examined whether variation at the rs1360780 SNP of FKBP5 gene moderated the association between childhood abuse and psychotic experiences. The discovery sample included 437 individuals and the replication sample included 305, all drawn from the general population. In both samples, a significant gene-environment interaction effect was detected indicating that T allele homozygotes of the FKBP5 gene scored significantly higher on positive PEs after exposure to childhood abuse compared to CC carriers. [-]
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Psychological Medicine (2016), 46, 221–223Rights
© Cambridge University Press 2015
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- PSB_Articles [1294]