Computational strategies for the design of new enzymatic functions
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Other documents of the author: Świderek, Katarzyna; Tuñón, Iñaki; Moliner, Vicent; Bertrán, Juan
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comunitat-uji-handle2:10234/7013
comunitat-uji-handle3:10234/8638
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Title
Computational strategies for the design of new enzymatic functionsDate
2015-09-15Publisher
ElsevierISSN
0003-9861Bibliographic citation
ŚWIDEREK, Katarzyna, et al. Computational strategies for the design of new enzymatic functions. Archives of biochemistry and biophysics, 2015, vol. 582, p. 68-79.Type
info:eu-repo/semantics/articlePublisher version
http://www.sciencedirect.com/science/article/pii/S0003986115001411Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
In this contribution, recent developments in the design of biocatalysts are reviewed with particular emphasis in the de novo strategy. Studies based on three different reactions, Kemp elimination, Diels–Alder and ... [+]
In this contribution, recent developments in the design of biocatalysts are reviewed with particular emphasis in the de novo strategy. Studies based on three different reactions, Kemp elimination, Diels–Alder and Retro-Aldolase, are used to illustrate different success achieved during the last years. Finally, a section is devoted to the particular case of designed metalloenzymes. As a general conclusion, the interplay between new and more sophisticated engineering protocols and computational methods, based on molecular dynamics simulations with Quantum Mechanics/Molecular Mechanics potentials and fully flexible models, seems to constitute the bed rock for present and future successful design strategies. [-]
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Archives of biochemistry and biophysics, 2015, vol. 582Rights
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