Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis
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Otros documentos de la autoría: Nieto Torres, José L.; Verdiá Báguena, Carmen; Castaño Rodríguez, Carlos; Aguilella, Vicente; Enjuanes, Luis
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/2507
comunitat-uji-handle3:10234/6973
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INVESTIGACIONMetadatos
Título
Relevance of Viroporin Ion Channel Activity on Viral Replication and PathogenesisAutoría
Fecha de publicación
2015-07Editor
MDPICita bibliográfica
NIETO-TORRES, Jose L., et al. Relevance of viroporin ion channel activity on viral replication and pathogenesis. Viruses, 2015, vol. 7, no 7, p. 3552-3573.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.mdpi.com/1999-4915/7/7/2786/htmVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Modification of host-cell ionic content is a significant issue for viruses, as several viral proteins displaying ion channel activity, named viroporins, have been identified. Viroporins interact with different cellular ... [+]
Modification of host-cell ionic content is a significant issue for viruses, as several viral proteins displaying ion channel activity, named viroporins, have been identified. Viroporins interact with different cellular membranes and self-assemble forming ion conductive pores. In general, these channels display mild ion selectivity, and, eventually, membrane lipids play key structural and functional roles in the pore. Viroporins stimulate virus production through different mechanisms, and ion channel conductivity has been proved particularly relevant in several cases. Key stages of the viral cycle such as virus uncoating, transport and maturation are ion-influenced processes in many viral species. Besides boosting virus propagation, viroporins have also been associated with pathogenesis. Linking pathogenesis either to the ion conductivity or to other functions of viroporins has been elusive for a long time. This article summarizes novel pathways leading to disease stimulated by viroporin ion conduction, such as inflammasome driven immunopathology. [-]
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Viruses, 2015, vol. 7, no 7Derechos de acceso
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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