Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis
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Altres documents de l'autoria: Nieto Torres, José L.; Verdiá Báguena, Carmen; Castaño Rodríguez, Carlos; Aguilella, Vicente; Enjuanes, Luis
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/2507
comunitat-uji-handle3:10234/6973
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Títol
Relevance of Viroporin Ion Channel Activity on Viral Replication and PathogenesisAutoria
Data de publicació
2015-07Editor
MDPICita bibliogràfica
NIETO-TORRES, Jose L., et al. Relevance of viroporin ion channel activity on viral replication and pathogenesis. Viruses, 2015, vol. 7, no 7, p. 3552-3573.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://www.mdpi.com/1999-4915/7/7/2786/htmVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Modification of host-cell ionic content is a significant issue for viruses, as several viral proteins displaying ion channel activity, named viroporins, have been identified. Viroporins interact with different cellular ... [+]
Modification of host-cell ionic content is a significant issue for viruses, as several viral proteins displaying ion channel activity, named viroporins, have been identified. Viroporins interact with different cellular membranes and self-assemble forming ion conductive pores. In general, these channels display mild ion selectivity, and, eventually, membrane lipids play key structural and functional roles in the pore. Viroporins stimulate virus production through different mechanisms, and ion channel conductivity has been proved particularly relevant in several cases. Key stages of the viral cycle such as virus uncoating, transport and maturation are ion-influenced processes in many viral species. Besides boosting virus propagation, viroporins have also been associated with pathogenesis. Linking pathogenesis either to the ion conductivity or to other functions of viroporins has been elusive for a long time. This article summarizes novel pathways leading to disease stimulated by viroporin ion conduction, such as inflammasome driven immunopathology. [-]
Publicat a
Viruses, 2015, vol. 7, no 7Drets d'accés
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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