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Macrocycle Synthesis by Chloride-Templated Amide Bond Formation
dc.contributor.author | Martí-Centelles, Vicente | |
dc.contributor.author | Burguete, M. Isabel | |
dc.contributor.author | Luis, Santiago V. | |
dc.date.accessioned | 2016-02-16T11:37:25Z | |
dc.date.available | 2016-02-16T11:37:25Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | MARTÍ-CENTELLES, Vicente; BURGUETE, Maria Isabel; LUIS, Santiago Vicente. Macrocycle Synthesis by Chloride Templated Amide Bond Formation. The Journal of Organic Chemistry, 2016. | ca_CA |
dc.identifier.issn | 0022-3263 | |
dc.identifier.issn | 1520-6904 | |
dc.identifier.uri | http://hdl.handle.net/10234/149972 | |
dc.description.abstract | A new family of pseudopeptidic macrocyclic compounds has been prepared involving an anion-templated amide bond formation reaction at the macrocyclization step. Chloride anion was found to be the most efficient template in the macrocyclization process, producing improved macrocyclization yields with regard to the nontemplated reaction. The data suggest a kinetic effect of the chloride template, providing an appropriate folded conformation of the openchain precursor and reducing the energy barrier for the formation of the macrocyclic product. | ca_CA |
dc.description.sponsorShip | This work was supported by the Spanish Ministry of Science and Innovation (CTQ2012-38543-C03) and Generalitat Valenciana (PROMETEO/2012/020). V.M.-C. thanks Generalitat Valenciana for a postdoctoral fellowship (APOSTD/ 2013/041). | |
dc.format.extent | 5 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | American Chemical Society | ca_CA |
dc.relation.isPartOf | The Journal of Organic Chemistry, Article ASAP | ca_CA |
dc.rights | ACS AuthorChoice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. | ca_CA |
dc.rights | Copyright © 2016 American Chemical Society | |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.title | Macrocycle Synthesis by Chloride-Templated Amide Bond Formation | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1021/acs.joc.5b02676 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | http://pubs.acs.org/doi/abs/10.1021/acs.joc.5b02676 | ca_CA |
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