Macrocycle Synthesis by Chloride-Templated Amide Bond Formation
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Altres documents de l'autoria: Martí-Centelles, Vicente; Burguete, M. Isabel; Luis, Santiago V.
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Títol
Macrocycle Synthesis by Chloride-Templated Amide Bond FormationData de publicació
2016Editor
American Chemical SocietyISSN
0022-3263; 1520-6904Cita bibliogràfica
MARTÍ-CENTELLES, Vicente; BURGUETE, Maria Isabel; LUIS, Santiago Vicente. Macrocycle Synthesis by Chloride Templated Amide Bond Formation. The Journal of Organic Chemistry, 2016.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://pubs.acs.org/doi/abs/10.1021/acs.joc.5b02676Resum
A new family of pseudopeptidic macrocyclic
compounds has been prepared involving an anion-templated
amide bond formation reaction at the macrocyclization step.
Chloride anion was found to be the most efficient ... [+]
A new family of pseudopeptidic macrocyclic
compounds has been prepared involving an anion-templated
amide bond formation reaction at the macrocyclization step.
Chloride anion was found to be the most efficient template in
the macrocyclization process, producing improved macrocyclization
yields with regard to the nontemplated reaction.
The data suggest a kinetic effect of the chloride template,
providing an appropriate folded conformation of the openchain
precursor and reducing the energy barrier for the
formation of the macrocyclic product. [-]
Publicat a
The Journal of Organic Chemistry, Article ASAPDrets d'accés
ACS AuthorChoice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
Copyright © 2016 American Chemical Society
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
Copyright © 2016 American Chemical Society
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
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