The Mechanism of the Interactions of Pironetin Analog/Combretastatin A-4 Hybrids with Tubulin
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Other documents of the author: Torijano Gutiérrez, Sandra Adela; Vilanova Gallén, Concepción; Diaz-Oltra, Santiago; Murga, Juan; Falomir, Eva; Carda, Miguel; Redondo Horcajo, Mariano; Fernando Díaz, J.; Barasoain, Isabel; Marco, J. Alberto
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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http://dx.doi.org/10.1002/ardp.201500106 |
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Title
The Mechanism of the Interactions of Pironetin Analog/Combretastatin A-4 Hybrids with TubulinAuthor (s)
Date
2015-06-17Publisher
WileyISSN
0365-6233Bibliographic citation
TORIJANO‐GUTIÉRREZ, Sandra, et al. The Mechanism of the Interactions of Pironetin Analog/Combretastatin A‐4 Hybrids with Tubulin. Archiv der Pharmazie, 2015, vol. 348, no 8, p. 541-547.Type
info:eu-repo/semantics/articlePublisher version
http://onlinelibrary.wiley.com/doi/10.1002/ardp.201500106/fullSubject
Abstract
We here report an investigation of the interactions with tubulin of two types of molecules of a hybrid structural type consisting in a combretastatin A-4 moiety and a simplified pironetin fragment. The cytotoxicities ... [+]
We here report an investigation of the interactions with tubulin of two types of molecules of a hybrid structural type consisting in a combretastatin A-4 moiety and a simplified pironetin fragment. The cytotoxicities of the molecules on two reference tumoral cell lines were measured. In addition, the effects of the compounds on the cell cycle and on microtubule assembly were observed. The dynamics of microtubule polymerization was investigated by means of immunofluorescence assays. It was thus established that at least some of the compounds under study exert their cytotoxic action by means of interaction with tubulin. [-]
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Archiv der Pharmazie, 2015, vol. 348, no 8Rights
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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