dc.contributor.author | Hernandez, Felix | |
dc.contributor.author | Ibáñez, Maria | |
dc.contributor.author | Bade, Richard | |
dc.contributor.author | Bijlsma, Lubertus | |
dc.contributor.author | Sancho, Juan V | |
dc.date.accessioned | 2016-01-12T16:17:06Z | |
dc.date.available | 2016-01-12T16:17:06Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | HERNÁNDEZ, F., et al. Investigation of pharmaceuticals and illicit drugs in waters by liquid chromatography-high-resolution mass spectrometry. TrAC Trends in Analytical Chemistry, 2014, vol. 63, p. 140-157. | ca_CA |
dc.identifier.issn | 0165-9936 | |
dc.identifier.uri | http://hdl.handle.net/10234/144825 | |
dc.description.abstract | Mass spectrometry (MS) coupled to chromatography has been increasingly used in the environmental field, as it allows the best performance currently attainable for the investigation of a wide range of organic pollutants. When dealing with emerging contaminants, there is a clear trend towards the use of liquid chromatography-mass spectrometry (LC-MS) techniques, from tandem (low-resolution) MS to high-resolution (HR) MS. HRMS allows targeted and untargeted analysis, thanks to full-spectrum acquisition at high mass accuracy with good sensitivity. With the same instrument, target, suspect and non-target screening can be performed, as can retrospective analysis and discovery of transformation/degradation products. This article gives a general overview on the use of HRMS in LC-based methods directed towards the investigation of illicit drugs and pharmaceuticals in the aqueous environment. We consider time-of-flight and Orbitrap mass analyzers, and we discuss the benefits of using ultra-high-performance liquid chromatography (UHPLC) in combination with HRMS. | ca_CA |
dc.description.sponsorShip | Plan Nacional de I+D+I, Ministerio de Economia y Competitividad. CTQ2012-36189
Generalitat Valenciana (Group of Excellence Prometeo). 2009/054
Generalitat Valenciana (Collaborative Research on Environment and Food Safety). ISIC/2012/016 | ca_CA |
dc.format.extent | 61 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Trends in Analytical Chemistry 63 (2014) 140–157 | ca_CA |
dc.rights | © 2014 Elsevier B.V. All rights reserved. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | Emerging contaminant | ca_CA |
dc.subject | High-resolution mass spectrometry (HRMS) | ca_CA |
dc.subject | Illicit drug | ca_CA |
dc.subject | LC-HRMS | ca_CA |
dc.subject | Liquid chromatography (LC) | ca_CA |
dc.subject | Orbitrap | ca_CA |
dc.subject | Pharmaceutical | ca_CA |
dc.subject | Screening | ca_CA |
dc.subject | Time of flight | ca_CA |
dc.subject | Transformation product | ca_CA |
dc.title | Investigation of pharmaceuticals and illicit drugs in waters by liquid chromatography-high-resolution mass spectrometry | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1016/j.trac.2014.08.003 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | http://www.sciencedirect.com/science/article/pii/S0165993614001964 | ca_CA |
dc.type.version | info:eu-repo/semantics/acceptedVersion | |