Investigation of pharmaceuticals and illicit drugs in waters by liquid chromatography-high-resolution mass spectrometry
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Otros documentos de la autoría: Hernandez, Felix; Ibáñez, Maria; Bade, Richard; Bijlsma, Lubertus; Sancho, Juan V
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Título
Investigation of pharmaceuticals and illicit drugs in waters by liquid chromatography-high-resolution mass spectrometryFecha de publicación
2014Editor
ElsevierISSN
0165-9936Cita bibliográfica
HERNÁNDEZ, F., et al. Investigation of pharmaceuticals and illicit drugs in waters by liquid chromatography-high-resolution mass spectrometry. TrAC Trends in Analytical Chemistry, 2014, vol. 63, p. 140-157.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0165993614001964Versión
info:eu-repo/semantics/acceptedVersionPalabras clave / Materias
Resumen
Mass spectrometry (MS) coupled to chromatography has been increasingly used in the environmental field, as it allows the best performance currently attainable for the investigation of a wide range of organic pollutants. ... [+]
Mass spectrometry (MS) coupled to chromatography has been increasingly used in the environmental field, as it allows the best performance currently attainable for the investigation of a wide range of organic pollutants. When dealing with emerging contaminants, there is a clear trend towards the use of liquid chromatography-mass spectrometry (LC-MS) techniques, from tandem (low-resolution) MS to high-resolution (HR) MS. HRMS allows targeted and untargeted analysis, thanks to full-spectrum acquisition at high mass accuracy with good sensitivity. With the same instrument, target, suspect and non-target screening can be performed, as can retrospective analysis and discovery of transformation/degradation products. This article gives a general overview on the use of HRMS in LC-based methods directed towards the investigation of illicit drugs and pharmaceuticals in the aqueous environment. We consider time-of-flight and Orbitrap mass analyzers, and we discuss the benefits of using ultra-high-performance liquid chromatography (UHPLC) in combination with HRMS. [-]
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Trends in Analytical Chemistry 63 (2014) 140–157Derechos de acceso
© 2014 Elsevier B.V. All rights reserved.
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