Investigation of pharmaceuticals and illicit drugs in waters by liquid chromatography-high-resolution mass spectrometry
View/ Open
Impact
Scholar |
Other documents of the author: Hernandez, Felix; Ibáñez, Maria; Bade, Richard; Bijlsma, Lubertus; Sancho, Juan V
Metadata
Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/33596
comunitat-uji-handle3:10234/33597
comunitat-uji-handle4:
INVESTIGACIONMetadata
Title
Investigation of pharmaceuticals and illicit drugs in waters by liquid chromatography-high-resolution mass spectrometryDate
2014Publisher
ElsevierISSN
0165-9936Bibliographic citation
HERNÁNDEZ, F., et al. Investigation of pharmaceuticals and illicit drugs in waters by liquid chromatography-high-resolution mass spectrometry. TrAC Trends in Analytical Chemistry, 2014, vol. 63, p. 140-157.Type
info:eu-repo/semantics/articlePublisher version
http://www.sciencedirect.com/science/article/pii/S0165993614001964Version
info:eu-repo/semantics/acceptedVersionSubject
Abstract
Mass spectrometry (MS) coupled to chromatography has been increasingly used in the environmental field, as it allows the best performance currently attainable for the investigation of a wide range of organic pollutants. ... [+]
Mass spectrometry (MS) coupled to chromatography has been increasingly used in the environmental field, as it allows the best performance currently attainable for the investigation of a wide range of organic pollutants. When dealing with emerging contaminants, there is a clear trend towards the use of liquid chromatography-mass spectrometry (LC-MS) techniques, from tandem (low-resolution) MS to high-resolution (HR) MS. HRMS allows targeted and untargeted analysis, thanks to full-spectrum acquisition at high mass accuracy with good sensitivity. With the same instrument, target, suspect and non-target screening can be performed, as can retrospective analysis and discovery of transformation/degradation products. This article gives a general overview on the use of HRMS in LC-based methods directed towards the investigation of illicit drugs and pharmaceuticals in the aqueous environment. We consider time-of-flight and Orbitrap mass analyzers, and we discuss the benefits of using ultra-high-performance liquid chromatography (UHPLC) in combination with HRMS. [-]
Is part of
Trends in Analytical Chemistry 63 (2014) 140–157Rights
© 2014 Elsevier B.V. All rights reserved.
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
This item appears in the folowing collection(s)
- IUPA_Articles [310]