Fast determination of 40 drugs in water using large volume direct injection liquid chromatography–tandem mass spectrometry
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Altres documents de l'autoria: Boix Sales, Clara; Ibáñez, Maria; Sancho, Juan V; Rambla, Javier; Aranda Mares, José Luis; Ballester, Salomé; Hernandez, Felix
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/33596
comunitat-uji-handle3:10234/33597
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Títol
Fast determination of 40 drugs in water using large volume direct injection liquid chromatography–tandem mass spectrometryAutoria
Data de publicació
2015Editor
ElsevierISSN
0039-9140Cita bibliogràfica
BOIX, Clara, et al. Fast determination of 40 drugs in water using large volume direct injection liquid chromatography–tandem mass spectrometry. Talanta, 2015, vol. 131, p. 719-727.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://www.sciencedirect.com/science/article/pii/S0039914014006754Versió
info:eu-repo/semantics/acceptedVersionParaules clau / Matèries
Resum
This work describes a rapid analytical method based on direct sample injection of water samples for the simultaneous identification/quantification of 40 emerging compounds, including pharmaceuticals and drugs of abuse. ... [+]
This work describes a rapid analytical method based on direct sample injection of water samples for the simultaneous identification/quantification of 40 emerging compounds, including pharmaceuticals and drugs of abuse. The water samples were analyzed by ultra-high-performance liquid chromatography coupled to hybrid triple quadrupole mass spectrometer (UHPLC–MS/MS QqQ). Taking profit of the increasing sensitivity of nowadays tandem mass spectrometers, direct sample injection of large volumes has been an attractive alternative to pre-concentration steps. In this work, the developed methodology has been validated at three concentration levels (10, 100 and 1000 ng/L) in 10 different water samples of different types (5 effluent wastewater and 5 surface water samples). The majority of compounds could be satisfactory validated at these concentrations, showing good recoveries and precision. With only few exceptions, the limits of quantification (LOQs), estimated from the sample chromatogram at lowest spiked level tested, were below 3 ng/L. The method was applied to the analysis of 10 effluent wastewater and 10 surface water samples. Venlafaxine was the compound most frequently detected (80%) in surface water, followed by acetaminophen (70%). Regarding effluent wastewater, valsartan and 4-acetyl aminoantipyrine were detected in 9 out of 10 samples analyzed. These two compounds together with 4-formyl aminoantipyrine and naproxen showed the highest concentrations (>2000 ng/L). In these cases, a dilution step was required for a correct quantification. As an additional evaluation of the method performance, the same water samples were analyzed in another laboratory by a second analytical methodology, based on on-line solid-phase-extraction coupled to LC–MS/MS (QqQ). [-]
Publicat a
Talanta, 2015, vol. 131Drets d'accés
Copyright © 2015 Elsevier B.V.
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info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
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