A data-independent acquisition workflow for qualitative screening of new psychoactive substances in biological samples
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Otros documentos de la autoría: Kinyua, Juliet; Negreira, Noelia; Ibáñez, Maria; Bijlsma, Lubertus; Hernandez, Felix; Covaci, Adrian; van Nuijs, Alexander
Metadatos
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INVESTIGACIONMetadatos
Título
A data-independent acquisition workflow for qualitative screening of new psychoactive substances in biological samplesAutoría
Fecha de publicación
2015Editor
SpringerISSN
1618-2650; 1618-2642Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://dx.doi.org/10.1007/s00216-015-9036-0Versión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
Identification of new psychoactive substances (NPS) is challenging. Developing targeted methods for their analysis can be difficult and costly due to their impermanence on the drug scene. Accurate-mass mass spectrometry ... [+]
Identification of new psychoactive substances (NPS) is challenging. Developing targeted methods for their analysis can be difficult and costly due to their impermanence on the drug scene. Accurate-mass mass spectrometry (AMMS) using a quadrupole time-of-flight (QTOF) analyzer can be useful for wide-scope screening since it provides sensitive, full-spectrum MS data. Our article presents a qualitative screening workflow based on data-independent acquisition mode (all-ions MS/MS) on liquid chromatography (LC) coupled to QTOFMS for the detection and identification of NPS in biological matrices. The workflow combines and structures fundamentals of target and suspect screening data processing techniques in a structured algorithm. This allows the detection and tentative identification of NPS and their metabolites. We have applied the workflow to two actual case studies involving drug intoxications where we detected and confirmed the parent compounds ketamine, 25B-NBOMe, 25C-NBOMe, and several predicted phase I and II metabolites not previously reported in urine and serum samples. The screening workflow demonstrates the added value for the detection and identification of NPS in biological matrices. [-]
Publicado en
Analytical and Bioanalytical Chemistry August 2015, Volume 407, Issue 29Derechos de acceso
© Springer-Verlag Berlin Heidelberg 2015
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info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
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