LC-QTOF MS screening of more than 1,000 licit and illicit drugs and their metabolites in wastewater and surface waters from the area of Bogotá, Colombia
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Other documents of the author: Hernandez, Felix; Ibáñez, Maria; Botero-Coy, Ana Maria; Bade, Richard; Bustos López, Martha Cristina; Rincón, Javier; Moncayo-Lasso, Alejandro; Bijlsma, Lubertus
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comunitat-uji-handle2:10234/33596
comunitat-uji-handle3:10234/33597
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Title
LC-QTOF MS screening of more than 1,000 licit and illicit drugs and their metabolites in wastewater and surface waters from the area of Bogotá, ColombiaAuthor (s)
Date
2015-08Publisher
SpringerISSN
1618-2650; 1618-2642Bibliographic citation
Hernández, F., Ibáñez, M., Botero-Coy, A. M., Bade, R., Bustos-López, M. C., Rincón, J., ... & Bijlsma, L. (2015). LC-QTOF MS screening of more than 1,000 licit and illicit drugs and their metabolites in wastewater and surface waters from the area of Bogotá, Colombia. Analytical and bioanalytical chemistry, 407(21), 6405-6416.Type
info:eu-repo/semantics/articlePublisher version
http://link.springer.com/article/10.1007%2Fs00216-015-8796-xVersion
info:eu-repo/semantics/acceptedVersionSubject
Abstract
A large screening of around 1,000 emerging contaminants, focused on licit and illicit drugs and their metabolites, has been made in urban wastewaters (both influent and effluent) and surface waters from the area of ... [+]
A large screening of around 1,000 emerging contaminants, focused on licit and illicit drugs and their metabolites, has been made in urban wastewaters (both influent and effluent) and surface waters from the area of Bogotá, Colombia. After a simple generic solid-phase extraction (SPE) step with Oasis hydrophilic-lipophilic balanced (HLB) cartridges, analyses were made by ultra high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-QTOF MS) under MSE mode (sequential acquisition of mass spectra at low energy (LE) and high collision energy (HE)). Accurate mass measurements and the information provided by MSE on the presence of the (de)protonated molecule and fragment ions allowed the reliable identification of the compounds detected, even without reference standards being available in some cases (tentative identification). The compounds most frequently found were acetaminophen/paracetamol, carbamazepine and its dihydro-dihydroxylated metabolite, clarithromycin, diclofenac, ibuprofen, gemfibrozil, lincomycin, losartan, valsartan, the two metabolites of metamizole (4-acetamido-antipyrine and 4-formylamino-antipyrine), sucralose, and cocaine and its main metabolite benzoylecgonine. Caffeine, the sweetener saccharin, and two hydroxylated metabolites of losartan were tentatively identified in almost all samples analyzed. Pharmaceutical lidocaine was tentatively identified and subsequently confirmed with reference standard. For the first time, a general overview of the occurrence of drugs and their metabolites in the aquatic environment of Colombia has been reported. In the near future, target methodologies, typically based on liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), will need to be set up for accurate and sensitive quantification of the contaminants selected on the basis on the information provided in the present paper. [-]
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Analytical and Bioanalytical Chemistry August 2015, Volume 407, Issue 21Rights
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