Entropy–enthalpy compensation at the single protein level: pH sensing in the bacterial channel OmpF
Impacte
Scholar |
Altres documents de l'autoria: Alcaraz, Antonio; Queralt-Martín, María; Verdiá Báguena, Carmen; Aguilella, Vicente; Mafe, Salvador
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/2507
comunitat-uji-handle3:10234/6973
comunitat-uji-handle4:
INVESTIGACIONAquest recurs és restringit
http://dx.doi.org/10.1039/c4nr03811h |
Metadades
Títol
Entropy–enthalpy compensation at the single protein level: pH sensing in the bacterial channel OmpFAutoria
Data de publicació
2014Editor
The Royal Society of ChemistryCita bibliogràfica
ALCARAZ, Antonio, et al. Entropy–enthalpy compensation at the single protein level: pH sensing in the bacterial channel OmpF. Nanoscale, 2014, vol. 6, no 24, p. 15210-15215.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://pubs.rsc.org/en/content/articlehtml/2014/nr/c4nr03811hVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
The pH sensing mechanism of the OmpF channel operates via ligand modification: increasing acidity induces the replacement of cations with protons in critical binding sites decreasing the channel conductance. Aside ... [+]
The pH sensing mechanism of the OmpF channel operates via ligand modification: increasing acidity induces the replacement of cations with protons in critical binding sites decreasing the channel conductance. Aside from the change in enthalpy associated with the binding, there is also a change in the microscopic arrangements of ligands, receptors and the surrounding solvent. We show that the pH-modulation of the single channel conduction involves small free energy changes because large enthalpic and entropic contributions change in opposite ways, demonstrating an approximate enthalpy–entropy compensation for different salts and concentrations. [-]
Publicat a
Nanoscale, 2014, vol. 6, no 24Drets d'accés
© The Royal Society of Chemistry 2014
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
Apareix a les col.leccions
- FCA_Articles [501]