Fluorescent macrocyclic probes with pendant functional groups as markers of acidic organelles within live cells
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Scholar |
Otros documentos de la autoría: Wadhavane, Prashant Dinkar; Izquierdo Arcusa, María Ángeles; Lutters, Dennis; Burguete, M. Isabel; Marín, María J.; Russell, David A.; Galindo, Francisco; Luis, Santiago V.
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http://dx.doi.org/10.1039/C3OB41773E |
Metadatos
Título
Fluorescent macrocyclic probes with pendant functional groups as markers of acidic organelles within live cellsAutoría
Fecha de publicación
2014Editor
Royal Society of ChemistryISSN
1477-0520; 1477-0539Cita bibliográfica
WADHAVANE, Prashant D., et al. Fluorescent macrocyclic probes with pendant functional groups as markers of acidic organelles within live cells. Organic & biomolecular chemistry, 2014, vol. 12, no 5, p. 823-831.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://pubs.rsc.org/en/Content/ArticleLanding/2014/OB/C3OB41773E#!divAbstractPalabras clave / Materias
Resumen
A new family of acidity sensitive fluorescent macrocycles has been synthesized and fully characterized. Their photophysical properties including emission quantum yield and fluorescence lifetime have been determined. ... [+]
A new family of acidity sensitive fluorescent macrocycles has been synthesized and fully characterized. Their photophysical properties including emission quantum yield and fluorescence lifetime have been determined. The acid–base properties of the new molecules can be tuned by the incorporation of pendant functional groups. The nature of such functional groups (carboxylic acid or ester) influences dramatically the pKa of the probes, two compounds of which exhibit low values. Preliminary intracellular studies using confocal microscopy together with emission spectra of the probes from the cellular environment have shown that the synthesized fluorescent macrocycles mark the acidic organelles of RAW 264.7 macrophage cells. [-]
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Organic & biomolecular chemistry, 2014, vol. 12, no 5Derechos de acceso
© 2014 The Royal Society of Chemistry.
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