Involvement of nitric oxide in the mitochondrial action of efavirenz: a differential effect on neurons and glial cells
Visualitza/
Impacte
Scholar |
Altres documents de l'autoria: Apostolova, Nadezda; Funes, Haryes A.; Blas García, Ana; Alegre, Fernando; Polo, Míriam; Esplugues Mota, Juan V.
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
comunitat-uji-handle4:
INVESTIGACIONMetadades
Títol
Involvement of nitric oxide in the mitochondrial action of efavirenz: a differential effect on neurons and glial cellsAutoria
Data de publicació
2014-12Editor
Oxford University PressCita bibliogràfica
APOSTOLOVA, Nadezda, et al. Involvement of nitric oxide in the mitochondrial action of efavirenz: a differential effect on neurons and glial cells. Journal of Infectious Diseases, 2015, 211.12: 1953-1958.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://jid.oxfordjournals.org/content/211/12/1953.shortParaules clau / Matèries
Resum
The anti-human immunodeficiency virus (HIV) drug efavirenz (EFV) alters mitochondrial function in cultured neurons and glial cells. Nitric oxide (NO) is a mediator of mitochondrial dysfunction associated with HIV ... [+]
The anti-human immunodeficiency virus (HIV) drug efavirenz (EFV) alters mitochondrial function in cultured neurons and glial cells. Nitric oxide (NO) is a mediator of mitochondrial dysfunction associated with HIV central nervous system symptoms. We show that EFV promotes inducible nitric oxide synthase (iNOS) expression in cultured glial cells and generated NO undermines their mitochondrial function, as inhibition of NOS partially reverses this effect. EFV inhibits mitochondrial Complex I in both neurons and glia; however, when the latter cells are treated for longer periods, other mitochondrial complexes are also affected in accordance with the increased NO production. These findings shed light on the mechanisms responsible for the frequent EFV-associated neurotoxicity. [-]
Publicat a
Journal of Infectious Diseases, 2015, 211.12Drets d'accés
© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
Apareix a les col.leccions
- MED_Articles [637]