Lipid charge regulation of non-specific biological ion channels
Impacto
Scholar |
Otros documentos de la autoría: Aguilella, Vicente; Verdiá Báguena, Carmen; Alcaraz, Antonio
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/2507
comunitat-uji-handle3:10234/6973
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http://dx.doi.org/10.1039/c3cp54690j |
Metadatos
Título
Lipid charge regulation of non-specific biological ion channelsFecha de publicación
2014Editor
Royal Society of ChemistryISSN
1463-9076; 1463-9084Cita bibliográfica
Phys. Chem. Chem. Phys., 2014, 16, 3881Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://pubs.rsc.org/en/content/articlepdf/2014/cp/c3cp54690jVersión
info:eu-repo/semantics/publishedVersionResumen
Ion channels are specialized proteins that enable the movement of charges through otherwise impermeable lipidic membranes. Their action is essential in living organisms facilitating electric signaling, muscle contraction ... [+]
Ion channels are specialized proteins that enable the movement of charges through otherwise impermeable lipidic membranes. Their action is essential in living organisms facilitating electric signaling, muscle contraction or osmotic stress response among other effects. The protein and the lipid charges configure a polarized interface that yields local ionic concentrations and electric potentials that are very different from those of the bulk electrolyte. The combined effect of gradients of ionic concentration and electric potential causes the transport of ions through channels. Here we analyze charge regulation effects in different protein–lipid conformations, stressing how important is the role of electrostatic interactions in the ion channel function that traditionally has been rationalized paying attention mainly to changes in pore size. Tuning lipid charge combined with conductance and selectivity measurements is shown to be a complementary method to evidence lipid involvement in the structure of a biological ion channel. [-]
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Phys. Chem. Chem. Phys., 2014, 16, 3881--3893Derechos de acceso
This journal is © the Owner Societies 2014
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