Intra-accumbens injections of the adenosine A(2A) agonist CGS 21680 affect effort-related choice behavior in rats
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Otros documentos de la autoría: Stopper, Colin M.; Worden, Lila T.; Mingote, Susana; Port, Russell G.; Salamone, John; Font Hurtado, Laura; Pereira, Mariana; Farrar, Andrew M.
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
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INVESTIGACIONMetadatos
Título
Intra-accumbens injections of the adenosine A(2A) agonist CGS 21680 affect effort-related choice behavior in ratsAutoría
Fecha de publicación
2008Editor
Springer VerlagISSN
00333158Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/acceptedVersionPalabras clave / Materias
Resumen
Rationale: Nucleus accumbens dopamine (DA) participates in the modulation of instrumental behavior,
including aspects of behavioral activation and effort-related choice behavior. Rats with impaired
accumbens DA ... [+]
Rationale: Nucleus accumbens dopamine (DA) participates in the modulation of instrumental behavior,
including aspects of behavioral activation and effort-related choice behavior. Rats with impaired
accumbens DA transmission reallocate their behavior away from food-reinforced activities that have high
response requirements, and instead select less-effortful types of food-seeking behavior. Although
accumbens DA is considered a critical component of the brain circuitry regulating effort-related
processes, emerging evidence also implicates adenosine A2A receptors. Objective: The present work was
undertaken to test the hypothesis that accumbens A2A receptor stimulation would produce effects similar
to those produced by DA depletion or antagonism. Methods: Three experiments assessed the effects of the
adenosine A2A agonist CGS 21680 on performance of a concurrent choice task (lever pressing for
preferred food vs. intake of less preferred chow) that is known to be sensitive to DA antagonists and
accumbens DA depletions. Results: Systemic injections of CGS 21680 reduced lever pressing but did not
increase feeding. In contrast, bilateral infusions of the adenosine A2A receptor agonist CGS 21680 (6.0-
24.0 ng) into the nucleus accumbens decreased lever pressing for the preferred food, but substantially
increased consumption of the less preferred chow. Injections of CGS 21680 into a control site dorsal to
the accumbens were ineffective. Conclusions: Taken together, these results are consistent with the
hypothesis that local stimulation of adenosine A2A receptors in nucleus accumbens produces behavioral
effects similar to those induced by accumbens DA depletions. Accumbens adenosine A2A receptors appear
to be a component of the brain circuitry regulating effort-related choice behavior [-]
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info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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