Diabetes and the brain: oxidative stress, inflammation, and autophagy
View/ Open
Impact
Scholar |
Other documents of the author: Muriach Saurí, María; Flores-Bellver, Miguel; Romero, Francisco J.; Barcia, Jorge M
Metadata
Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
comunitat-uji-handle4:
INVESTIGACIONMetadata
Title
Diabetes and the brain: oxidative stress, inflammation, and autophagyDate
2014Publisher
Hindawi Publishing CorporationType
info:eu-repo/semantics/articlePublisher version
http://www.hindawi.com/journals/omcl/2014/102158/Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Diabetes mellitus is a common metabolic disorder associated with chronic complications including a state of mild to moderate
cognitive impairment, in particular psychomotor slowing and reduced mental flexibility, not ... [+]
Diabetes mellitus is a common metabolic disorder associated with chronic complications including a state of mild to moderate
cognitive impairment, in particular psychomotor slowing and reduced mental flexibility, not attributable to other causes, and shares
many symptoms that are best described as accelerated brain ageing. A common theory for aging and for the pathogenesis of this
cerebral dysfunctioning in diabetes relates cell death to oxidative stress in strong association to inflammation, and in fact nuclear
factor kB (NFkB), a master regulator of inflammation and also a sensor of oxidative stress, has a strategic position at the crossroad
between oxidative stress and inflammation. Moreover, metabolic inflammation is, in turn, related to the induction of various
intracellular stresses such as mitochondrial oxidative stress, endoplasmic reticulum (ER) stress, and autophagy defect. In parallel,
blockade of autophagy can relate to proinflammatory signaling via oxidative stress pathway and NFkB-mediated inflammation. [-]
Is part of
Oxidative Medicine and Cellular Longevity, Volume 2014, Article ID 102158Rights
info:eu-repo/semantics/openAccess
This item appears in the folowing collection(s)
- MED_Articles [632]
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as Copyright © 2014 María Muriach et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.