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Mediterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymorphism on Cardiovascular Risk Factors and Stroke Incidence
dc.contributor.author | Corella, Dolores | |
dc.contributor.author | Carrasco, Paula | |
dc.contributor.author | Sorlí, José V | |
dc.contributor.author | Estruch, Ramon | |
dc.contributor.author | Rico Sanz, Jesús | |
dc.contributor.author | Martínez González, Miguel Ángel | |
dc.contributor.author | Salas-Salvadó, Jordi | |
dc.contributor.author | Covas Planells, María Isabel | |
dc.contributor.author | Coltell, Oscar | |
dc.contributor.author | Arós, Fernando | |
dc.contributor.author | Lapetra, José | |
dc.contributor.author | Serra-Majem, Lluis | |
dc.contributor.author | Ruiz-Gutiérrez, Valentina | |
dc.contributor.author | Warnberg, Julia | |
dc.contributor.author | Fiol Ramis, Miquel | |
dc.contributor.author | Pintó, Xavier | |
dc.contributor.author | CAROLINA, ORTEGA-AZORÍN | |
dc.contributor.author | Muñoz, Miguel Ángel | |
dc.contributor.author | Martínez, J. Alfredo | |
dc.contributor.author | Gómez Gracia, Enrique | |
dc.contributor.author | González, José I. | |
dc.contributor.author | Ros, Emilio | |
dc.contributor.author | Ordovás Muñoz, José M. | |
dc.date.accessioned | 2015-01-13T13:36:15Z | |
dc.date.available | 2015-01-13T13:36:15Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0149-5992 | |
dc.identifier.uri | http://hdl.handle.net/10234/112283 | |
dc.description.abstract | OBJECTIVE Transcription factor 7-like 2 (TCF7L2) polymorphisms are strongly associated with type 2 diabetes, but controversially with plasma lipids and cardiovascular disease. Interactions of the Mediterranean diet (MedDiet) on these associations are unknown. We investigated whether the TCF7L2-rs7903146 (C>T) polymorphism associations with type 2 diabetes, glucose, lipids, and cardiovascular disease incidence were modulated by MedDiet. RESEARCH DESIGN AND METHODS A randomized trial (two MedDiet intervention groups and a control group) with 7,018 participants in the PREvención con DIetaMEDiterránea study was undertaken and major cardiovascular events assessed. Data were analyzed at baseline and after a median follow-up of 4.8 years. Multivariable-adjusted Cox regression was used to estimate hazard ratios (HRs) for cardiovascular events. RESULTS The TCF7L2-rs7903146 polymorphism was associated with type 2 diabetes (odds ratio 1.87 [95% CI 1.62–2.17] for TT compared with CC). MedDiet interacted significantly with rs7903146 on fasting glucose at baseline (P interaction = 0.004). When adherence to the MedDiet was low, TT had higher fasting glucose concentrations (132.3 ± 3.5 mg/dL) than CC+CT (127.3 ± 3.2 mg/dL) individuals (P = 0.001). Nevertheless, when adherence was high, this increase was not observed (P = 0.605). This modulation was also detected for total cholesterol, LDL cholesterol, and triglycerides (P interaction < 0.05 for all). Likewise, in the randomized trial, TT subjects had a higher stroke incidence in the control group (adjusted HR 2.91 [95% CI 1.36–6.19]; P = 0.006 compared with CC), whereas dietary intervention with MedDiet reduced stroke incidence in TT homozygotes (adjusted HR 0.96 [95% CI 0.49–1.87]; P = 0.892 for TT compared with CC). CONCLUSIONS Our novel results suggest that MedDiet may not only reduce increased fasting glucose and lipids in TT individuals, but also stroke incidence. | ca_CA |
dc.format.extent | 9 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | American Diabetes Association | ca_CA |
dc.relation.isPartOf | Diabetes Care (November 2013), vol. 36, no. 11, p. 3803-3811 | ca_CA |
dc.rights | © 2013 by the American Diabetes Association. Creative Commons BY-NC-ND 4.0 | ca_CA |
dc.rights | Attribution-NonCommercial-NoDerivs 4.0 Spain | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Mediterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymorphism on Cardiovascular Risk Factors and Stroke Incidence | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.2337/dc13-0955 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | http://care.diabetesjournals.org/content/36/11/3803.short | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion |
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