Listar por tema "monomers"
Mostrando ítems 1-3 de 3
-
Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog
American Chemical Society (2021-04-08)Methylation of 2-deoxyuridine-5′-monophosphate (dUMP) at the C5 position by the obligate dimeric thymidylate synthase (TSase) in the sole de novo biosynthetic pathway to thymidine 5′-monophosphate (dTMP) proceeds by forming ... -
Mechanistic Modeling of Lys745 Sulfonylation in EGFR C797S Reveals Chemical Determinants for Inhibitor Activity and Discriminates Reversible from Irreversible Agents
American Chemical Society (2023-02-10)Targeted covalent inhibitors hold promise for drug discovery, particularly for kinases. Targeting the catalytic lysine of epidermal growth factor receptor (EGFR) has attracted attention as a new strategy to overcome ... -
Unrevealing the Proteolytic Activity of RgpB Gingipain from Computational Simulations
American Chemical Society (2021-09-02)Alzheimer’s disease represents one of the greatest medical concerns for today’s population and health services. Its multifactorial inherent nature represents a challenge for its treatment and requires the development of a ...