Listar por tema "cerebellum"
Mostrando ítems 1-15 de 15
-
¿Afecta la lesión dorsal del cerebelo posterior a la actividad neuronal del tálamo? ¿Los cambios de actividad están relacionados con la memoria condicionada inducida por cocaína?
Universitat Jaume I (2016-07-19)La adicción es un trastorno crónico del cerebro que se caracteriza por el consumo y la búsqueda compulsiva de la droga a pesar de sus consecuencias negativas. Los estudios previos indican que el cerebelo está implicado en ... -
Beyond the basal ganglia: cFOS expression in the cerebellum in response to acute and chronic dopaminergic alterations
Elsevier (2014)The suggestion of an anatomical and functional relationship between the basal ganglia and cerebellum is recent. Traditionally, these structures were considered as neuronal circuits working separately to organize and control ... -
Efectos de la degradación de las redes perineuronales en el estrés oxidativo
Universitat Jaume I (2017-07-18)Introducción: Uno de los mecanismos clave para la estabilización de los cambios sinápticos es la formación de estructuras específicas de la matriz extracelular que rodean a varias poblaciones neuronales al final del ... -
Effects of perineuronal nets degradation by ChABC on neuronal activity in the cerebellar cortex
Universitat Jaume I (2017-07-19)Introduction. One of the key mechanisms for the stabilization of synaptic changes is the formation of specific extracellular matrix structures surrounding several neuronal populations at the end of the brain development, ... -
From back to front: A functional model for the cerebellar modulation in the establishment of conditioned preferences for cocaine‐related cues
Wiley (2019)It is now increasingly clear that the cerebellum may modulate brain functions altered in drug addiction. We previously demonstrated that cocaine‐induced conditioned preference increased activity at the dorsal posterior ... -
Have we been ignoring the elephant in the room? Seven arguments for considering the cerebellum as part of addiction circuitry
Elsevier (2016)Addiction involves alterations in multiple brain regions that are associated with functions such as memory, motivation and executive control. Indeed, it is now well accepted that addictive drugs produce long-lasting molecular ... -
Learning the visual-oculomotor transformation: Effects on saccade control and space representation
Elsevier (2015-09)Active eye movements can be exploited to build a visuomotor representation of the surrounding environment. Maintaining and improving such representation requires to update the internal model involved in the generation of ... -
Multiunit Recording of the Cerebellar Cortex, Inferior Olive, and Fastigial Nucleus During Copulation in Naive and Sexually Experienced Male Rats
Springer-Verlag (2010-03)The sexual behavior of male rats constitutes a natural model to study learning of motor skills at the level of the central nervous system. We previously showed that sexual behavior increases Fos expression in granule cells ... -
Neural correlates of cocaine-induced conditioned place preference in the posterior cerebellar cortex
Frontiers Media (2023)Introduction: Addictive drugs are potent neuropharmacological agents capable of inducing long-lasting changes in learning and memory neurocircuitry. With repeated use, contexts and cues associated with consumption can ... -
Putting forward a model for the role of the cerebellum in cocaine-induced pavlovian memory
Frontiers Media (2023)Substance Use Disorder (SUD) involves emotional, cognitive, and motivational dysfunction. Long-lasting molecular and structural changes in brain regions functionally and anatomically linked to the cerebellum, such as the ... -
Role of Perineuronal nets in the cerebellar cortex in cocaine-induced conditioned preference, extinction, and reinstatement
Elsevier Ltd (2022-08-17)Perineuronal nets (PNNs) are cartilage-like structures of extracellular matrix molecules that enwrap in a net-like manner the cell-body and proximal dendrites of special subsets of neurons. PNNs stabilize their incoming ... -
The Cerebellum on Cocaine
Frontiers Media (2020-10-21)The traditional cerebellum’s role has been linked to the high computational demands for sensorimotor control. However, several findings have pointed to its involvement in executive and emotional functions in the last ... -
Time-dependent regulation of perineuronal nets in the cerebellar cortex during abstinence of cocaine-self administration
Springer (2021-01-03)Rationale The probability of structural remodeling in brain circuits may be modulated by molecules of perineuronal nets (PNNs) that restrict neuronal plasticity to stabilize circuits. Animal research demonstrates that ... -
Unravelling the role of the cerebellum in drug addiction. Cerebellum-prefrontal networks in drug-induced preference memory
Universitat Jaume I (2019-06-14)This doctoral thesis is the first to propose a causative working model for the cerebellum's role in drug-induced memories. We managed to explore the role of the cerebellum in cocaine-induced conditioned preference and its ... -
When the front fails, the rear wins : cerebellar correlates of prefrontal dysfunction in cocaine-induced memory in male rats
Elsevier ScienceDirect (2021-08-18)Reciprocal pathways connecting the cerebellum to the prefrontal cortex provide a biological and functional substrate to modulate cognitive functions. Dysfunction of both medial prefrontal cortex (mPFC) and cerebellum ...