Listar por tema "Preorganization"
Mostrando ítems 1-3 de 3
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Designed folding of pseudopeptides: the transformation of a configurationally driven preorganization into a stereoselective multicomponent macrocyclization
VCH Verlagsgesellschaf (2008)The efficient synthesis of large-ring pseudopeptidic macrocycles through a multicomponent [2+2] reductive amination reaction is described. The reaction was entirely governed by the structural information contained in the ... -
Efficient Synthesis of Pseudopeptidic Molecular Cages
Wiley (2012-04)Pseudopeptidic cages have been efficiently prepared by combining a dynamic covalent procedure with the suitable preorganization of the building blocks by a conformational bias or an anion templation. -
On the relationship between folding and chemical landscapes in enzyme catalysis
National Academy of Sciences (2008-09-16)Elucidating the relationship between the free energy landscape of enzymes and their catalytic power has been one of the challenges of modern enzymology. The present work explores this issue by using a simplified folding ...