• openAccess   MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease 

      MILARA, JAVIER; Díaz-Platas, Lucía; Contreras, Sonia; Ribera, Pilar; Roger, Inés; Ballester, Beatriz; Montero, Paula; Cogolludo, Ángel; Morcillo, Esteban; Cortijo, Julio BMC (2018)
      Background Lung inflammation in COPD is poorly controlled by inhaled corticosteroids (ICS). Strategies to improve ICS efficacy or the search of biomarkers who may select those patients candidates to receive ICS in COPD ...
    • closedAccess   Mucin 1 deficiency mediates corticosteroid insensitivity in asthma 

      MILARA, JAVIER; Morell, Anselm; de Diego, Alfredo; Artigues, Enrique; Morcillo, Esteban; Cortijo, Julio Wiley (2019-01)
      BACKGROUND: The loss of corticosteroid efficacy is an important issue in severe asthma management and may lead to poor asthma control and deterioration of airflow. Recent data indicate that Mucin 1 (MUC1) membrane mucin ...