Listar por tema "Dopamine"
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Assessment of a glycine uptake inhibitor in animal models of effort-related choice behavior: implications for motivational dysfunctions
Springer Verlag (2017)Rationale Motivated behavior can be characterized by a substantial exertion of effort, and organisms often make effortrelated decisions based upon analyses of work-related response costs and reinforcement preference. ... -
Assessment of a glycine uptake inhibitor in animal models of effort-related choice behavior: implications for motivational dysfunctions
Springer Verlag (2017)Rationale Motivated behavior can be characterized by a substantial exertion of effort, and organisms often make effortrelated decisions based upon analyses of work-related response costs and reinforcement preference. ... -
Bases biológicas del consumo compulsivo del azúcar
Universitat Jaume I (2017)En la actualidad, los trastornos de conducta alimentaria están recibiendo una notoria atención, pues cada vez son más frecuentes y aparecen en edades más tempranas. Este consumo disparatado de grasas y azúcar está ... -
Behavioral and dopamine transporter binding properties of the modafinil analog (S, S)-CE-158: reversal of the motivational effects of tetrabenazine and enhancement of progressive ratio responding
Springer (2020)Rationale Atypical dopamine (DA) transport blockers such as modafinil and its analogs may be useful for treating motivational symptoms of depression and other disorders. Previous research has shown that the DA depleting ... -
Behavioral manipulations for the improvement of anergia: impact on the mesolimbic dopaminergic system
Universitat Jaume I (2016-07-20)Studies with animals have shown that exercise can have neuroprotective effects which has led to suggestions that physical exercise could have positive effects in the prevention/treatment of various neurologic or psychiatric ... -
Blockade of uptake for dopamine, but not norepinephrine or 5-HT, increases selection of high effort instrumental activity: Implications for treatment of effort-related motivational symptoms in psychopathology
Elsevier (2016)Deficits in behavioral activation, exertion of effort, and other psychomotor/motivational symptoms are frequently seen in people with depression and other disorders. Depressed people show a decision bias towards selection ... -
c-Fos immunoreactivity in prefrontal, basal ganglia and limbic areas of the rat brain after central and peripheral administration of ethanol and its metabolite acetaldehyde
Frontiers (2013)Considerable evidence indicates that the metabolite of ethanol (EtOH), acetaldehyde, is biologically active. Acetaldehyde can be formed from EtOH peripherally mainly by alcohol dehydrogenase (ADH), and also centrally by ... -
Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression
Frontiers Media (2018-06-01)Major depressive disorder is one of the most common and debilitating psychiatric disorders. Some of the motivational symptoms of depression, such anergia (lack of self-reported energy) and fatigue are relatively resistant ... -
Dopamine antagonists reduce selection of reinforcers that require vikgor: correlation with DARPP32
Universitat Jaume I (2018-09-11)Introduction: Dopamine (DA) is a neurotransmitter that is involved in vigor, persistence and work output in normal motivation. In fact, nucleus accumbens (Nacb) DA is a critical component of the neural circuitry that ... -
Dopamine depletion shifts behavior from activity based reinforcers tomore sedentary ones and adenosine receptor antagonism reversesthat shift: Relation to ventral striatum DARPP32 phosphorylationpatterns
Elsevier (2018)The mesolimbic dopamine (DA) system plays a critical role in behavioral activation and effort-baseddecision-making. DA depletion produces anergia (shifts to low effort options) in animals tested oneffort-based decision-making ... -
Dopamine/adenosine interactions related to locomotion and tremor in animal models: Possible relevance to parkinsonism
Elsevier (2008)Adenosine A<sub>2A</sub> antagonists can exert antiparkinsonian effects in animal models. Recent experiments studied the ability of MSX-3 (an adenosine A<sub>2A</sub> antagonist) to reverse the locomotor suppression and ... -
Efavirenz induces anergia in animal models for the study of the activational deficits observed in depression : therapeutic effect of the chatecolamine uptake inhibitor bupropion
Universitat Jaume I (2016-07-18)A high degree of behavioral activation and work output are observed in motivated behaviors. Mesolimbic DA plays an important role in the regulation of this activational component of motivation. Anergia and fatigue are ... -
Efectos del metilfenidato sobre la ansiedad
(2013-04-15)The attention deficit disorder with hyperactivity (ADDH) is a widely recognized disorder of unknown etiology. Methylphenidate administration is one of the most commonly used treatments to improve symptoms associated with ... -
Effect of subtype-selective adenosine receptor antagonists on basal or haloperidol-regulated striatal function: Studies of exploratory locomotion and c-Fos immunoreactivity in outbred and A2AR KO mice
Elsevier (2013-06-15)Behavioral activation is regulated by dopamine (DA) in striatal areas. At low doses, while typical antipsychotic drugs produce psychomotor slowing, psychostimulants promote exploration. Minor stimulants such as caffeine, ... -
Effects of lisdexamfetamine and s-citalopram, alone and in combination, on effort-related choice behavior in the rat
Springer Verlag (2016)Rationale Effort-related motivational symptoms, such as anergia, psychomotor retardation, and fatigue, are an important aspect of depression and other disorders. Motivational symptoms are resistant to some treatments, ... -
Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization
Springer Verlag (2016)Rationale Motivational dysfunctions such as anergia, fatigue, and reduced effort expenditure are common in patients with depression and other disorders. Pro-inflammatory cytokines are implicated in depression, and ... -
Evaluation of the effort-related motivational effects of the novel dopamine uptake inhibitor PRX-14040
Elsevier (2016)Psychiatric disorders are often marked by effort-related motivational symptoms such as anergia, fatigue, psychomotor retardation, and alterations in effort-based decision making. Animal studies of effort-related choice ... -
Evidencia conductual y neurobiológica del potencial adictivo del azúcar
Universitat Jaume I (2017-07-17)The massive use of sugar in the food industry, and the high rates of obesity documented by the WHO, have fueled the investigation of the addictive properties of this substance. In the present manuscript we review evidence ... -
Impacto del ejercicio físico sobre los sistemas dopaminérgicos: relevancia para la elección de reforzadores activos y la prevención de la anergia en modelos animales.
Universitat Jaume I (2015-06-15)Introduction Sedentary Modern lifestyles are associated with an increased risk of pathologies such as obesity, cardiovascular diseases or depression, while physical activity has demonstrated to improve brain health and ... -
Individual differences in running wheel performance are related to preferences for active reinforcers: the role of Nucleus Accumbens CDNF.
Universitat Jaume I (2019-07-25)Exercise has been demonstrated to have a positive impact on psychological well-being and mental health. Nucleus Accumbens (Nacb) dopamine (DA) has been implicated in regulating the energizing component of motivated ...