Listar por tema "Diabetes"
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Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulate by diet, being higher when adherence to the Mediterranean diet pattern is low
BioMed Central (2012-11)Background: Although the Fat Mass and Obesity (FTO) and Melanocortin-4 Receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is ... -
CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial
BioMed Central (2016-01)Background Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by ... -
Diabetes and the brain: oxidative stress, inflammation, and autophagy
Hindawi Publishing Corporation (2014)Diabetes mellitus is a common metabolic disorder associated with chronic complications including a state of mild to moderate cognitive impairment, in particular psychomotor slowing and reduced mental flexibility, not ... -
Estudio de las alteraciones del metabolismo hidrocarbonado en pacientes cirróticos sometidos a trasplante hepático. Impacto del control intensivo de la glucemia durante la estancia hospitalaria
Universitat Jaume I (2017-07-28)El estudio se estructura en tres objetivos principales. En el primero, se categorizaron las alteraciones del metabolismo hidrocarbonado en pacientes con cirrosis, mediante un test de tolerancia antes, a los 6 y 12 meses ... -
Evaluation of prophylaxis in primary prevention with acetylsalicylic acid in people with diabetes: A scoping review
Sociedad Española de Médicos de Atención Primaria (2022-02)The efficacy and safety of acetylsalicylic acid (ASA) prophylaxis for the primary prevention of atherosclerotic cardiovascular disease (ACVD) remain controversial in people with diabetes (DM) without ACVD, because the ... -
Insulin signaling in hippocampus
Universitat Jaume I (2017-09-21)Neuroinflammation and insulin resistance are known to underlie many neurological alterations, including Alzheimer's disease. Neuroinflammation is associated with chronic microglia activation, which induces ... -
IRS-2 deficiency impairs NMDA receptor-dependent long-term potentiation
Oxford University Press (2012-08)The beneficial effects of insulin and insulin-like growth factor I on cognition have been documented in humans and animal models. Conversely, obesity, hyperinsulinemia, and diabetes increase the risk for neurodegenerative ... -
Overexpression of glucose 6 phosphate dehydrogenase preserves mouse pancreatic beta cells function until late in life
Elsevier (2021-01)NAD(P)H donates electrons for reductive biosynthesis and antioxidant defense across all forms of life. Glucose-6- phosphate dehydrogenase (G6PD) is a critical enzyme to provide NADPH. G6PD deficiency is present in more than ... -
Perspectives and Potential Applications of Mitochondria-Targeted Antioxidants in Cardiometabolic Diseases and Type 2 Diabetes
John Wiley & Sons (2013)There is abundant evidence to suggest that mitochondrial dysfunction is a main cause of insulin resistance and related cardiometabolic comorbidities. On the other hand, insulin resistance is one of the main characteristics ... -
Structural violence, Diabetes and Agrocolonialism. A case study of the United States, Mexico, India and the Pacific Islands
Universitat Jaume I (2015-07)This dissertation will focus on how agricultural policies can be a form of structural violence and how part of this violence manifests itself in the form of Diabetes Mellitus, which is the name for a group of non-communicable ...