Listar por tema "Amino acids"
Mostrando ítems 1-10 de 10
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Amino acid tissue levels and GABAa receptor binding in the developing rat cerebellum following status epilepticus
Elsevier (2012)Incidence of status epilepticus (SE) is higher in children than in adults and SE can be induced in developing rats. The cerebellum can be affected after SE; however, consequences of cerebellar amino acid transmission ... -
Dynamics and Reactivity in Thermus aquaticus N6-Adenine Methyltransferase
American Chemical Society (2014)M.TaqI is a DNA methyltransferase from Thermus aquaticus that catalyzes the transfer of a methyl group from S-adenosyl-l-methionine to the N6 position of an adenine, a process described only in prokaryotes. We have used ... -
Macro- and nanoscale self-assembled amino acid derivatives as reduction-sensitive and photoactive materials
Universitat Jaume I (2022-05-23)Amino acid-based systems are attractive for biomedical applications given their high biocompatibility and functionality. Amino acids self-assemble into various structures ranging from a few nanometers to hundreds of microns ... -
Ratiometric fluorescence sensing of phenylalanine derivatives by synthetic macrocyclic receptors
Elsevier (2010)The supramolecular analytical behavior of eight pseudopeptidic fluorescent receptors (1a-c, 2a-c, 3, 4) has been studied. The receptors are either macrocyclic or open chain derivatives based on the naphthalene chromophore. ... -
Synthesis of Chiral Ionic Liquids derived from Amino Acids
Universitat Jaume I (2016-06-24) -
Synthesis of chiral room temperature ionic liquids from amino acids – application in chiral molecular recognition
Wiley-VCH Verlag (2012)A series of structurally new room temperature chiral ionic liquids based on an imidazolium group and derived from natural amino acids have been synthesized and studied as chiral shift agents for the chiral discrimination ... -
The Role of the Amino Acid Derived Side Chain in the Preorganization of C2 Symmetric Pseudopeptides: Effect on SN2 Macrocyclization Reactions
American Chemical Society (2013-12)A family of pseudopeptidic macrocycles containing non-natural amino acids have been synthesized. The macrocyclization reaction has been studied experimentally and computationally, demonstrating the key role of both the ... -
Theoretical Study of the Phosphoryl Transfer Reaction from ATP to Dha Catalyzed by DhaK from Escherichia coli
American Chemical Society (2017-09)Protein kinases, representing one of the largest protein families involved in almost all aspects of cell life, have become one of the most important targets for the development of new drugs to be used in, for instance, ... -
Thermodynamic and Kinetic Study of the Fibrillization of a Family of Tetrapeptides and Its Application to Self-Sorting. What Takes So Long?
American Chemical Society (2015-04-13)Insight is provided into the thermodynamics and kinetics of peptide fibrillization, a process of particular interest in biomedicine due to its direct relationship to amyloid diseases. The studied isomeric tetrapeptides are ... -
Using Grote-Hynes theory to quantify dynamical effects on the reaction rate of enzymatic processes. The case of Methyltransferases
American Chemical Society (2008)Dynamical effects have recently received much attention in the context of the theoretical investigation of enzymatic catalysis. In this paper we use a combination of Grote−Hynes theory with quantum mechanical/molecular ...