Listar por autoría "ef8948cc-ba22-4f2b-bf34-3d84ac495cdd"
Mostrando ítems 1-18 de 18
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A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics
Corella, Dolores; Coltell, Oscar; Portolés, Olga; Sotos-Prieto, Mercedes; Fernández-Carrión, Rebeca; Ramírez-Sabio, Judith B.; Zanón-Moreno, Vicente; Mattei, Josiemer; Sorlí, José V; Ordovás Muñoz, José M. MDPI (2019)Precision nutrition aims to make dietary recommendations of a more personalized nature possible, to optimize the prevention or delay of a disease and to improve health. Therefore, the characteristics (including sex) of ... -
Association of the LCT-13910C>T polymorphism with obesity and its modulation by dairy products in a Mediterranean population
Corella, Dolores; Arregui, María; Coltell, Oscar; Portolés, Olga; Guillem Sáiz, Patricia; Carrasco, Paula; Sorlí, José V; CAROLINA, ORTEGA-AZORÍN; González, José I.; Ordovás Muñoz, José M. Nature Publishing Group (2011-08)The -13910C>T polymorphism (rs4988235) upstream from the lactase (LCT) gene, strongly associated with lactase persistence (LP) in Europeans, is emerging as a new candidate for obesity. We aimed to analyze the association ... -
Associations between taste perception profiles and empirically derived dietary patterns: an exploratory analysis among older adults with metabolic syndrome
Gervis, Julie; Fernandez Carrion, Rebeca; Chui, Kenneth; Ma, Jiantao; Coltell, Oscar; Sorlí, José V; Asensio, Eva Maria; CAROLINA, ORTEGA-AZORÍN; Pérez-Fidalgo, J. Alejandro; Portolés, Olga; Lichtenstein, Alice H; Corella, Dolores MDPI (2021-12-29)Taste perception is a primary driver of food choices; however, little is known about how perception of all five tastes (sweet, salt, sour, bitter, umami) collectively inform dietary patterns. Our aim was to examine the ... -
Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects
Barragán-Arnal, Rocío; Coltell, Oscar; Portolés, Olga; Asensio, Eva Maria; Sorlí, José V; CAROLINA, ORTEGA-AZORÍN; González, José I.; Sáiz, Carmen; Fernández-Carrión, Rebeca; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2018)There is growing interest in relating taste perception to diet and healthy aging. However, there is still limited information on the influence of age, sex and genetics on taste acuity as well as on the relationship between ... -
Candidate Gene and Genome-Wide Association Studies for Circulating Leptin Levels Reveal Population and Sex-Specific Associations in High Cardiovascular Risk Mediterranean Subjects
CAROLINA, ORTEGA-AZORÍN; Coltell, Oscar; Asensio, Eva Maria; Sorlí, José V; González, José I.; Portolés, Olga; Saiz, Carmen; Estruch, Ramon; Ramírez-Sabio, Judith B.; Pérez-Fidalgo, J. Alejandro; Ordovas, Jose; Corella, Dolores MDPI (2019)Leptin is a hormone crucial in the regulation of food intake and body-weight maintenance. However, the genes and gene variants that influence its plasma levels are still not well known. Results of studies investigating ... -
Circulating adiponectin and Its association with metabolic traits and Type 2 Diabetes: gene-diet interactions focusing on selected gene variants and at the genome-wide level in high-cardiovascular risk mediterranean subjects
Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Portolés, Olga; Asensio, Eva Maria; Saiz, Carmen; Barragán-Arnal, Rocío; Estruch, Ramon; Corella, Dolores MDPI (2021-02-07)Adiponectin is gaining renewed interest since, in addition to its possible protective role against insulin resistance and arteriosclerosis, recent studies suggest other additional favorable effects. However, the influence ... -
Crosstalk between smoking and the genome in older subjects with metabolic syndrome through genomics, epigenomics and transcriptomics
Coltell, Oscar; Asensio, Eva Maria; CAROLINA, ORTEGA-AZORÍN; Barragán-Arnal, Rocío; Sáiz, Carmen; Portolés, Olga; Sorlí, José V; Corella, Dolores European Molecular Biology Organization (EMBO) (2019-09-11)Tobacco smoking (Figure 1) is a major cause of cardiovascular diseases (CVD), and appears to have a multiplicative interaction with the other major CVD risk factors (lipids, hypertension, diabetes and others present in the ... -
Effect of Physical Activity, Smoking, and Sleep on Telomere Length: A Systematic Review of Observational and Intervention Studies
Barragán-Arnal, Rocío; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Asensio, Eva Maria; Coltell, Oscar; St-Onge, Marie-Pierre; Portolés, Olga; Corella, Dolores MDPI (2021-12-24)Aging is a risk factor for several pathologies, restricting one’s health span, and promoting chronic diseases (e.g., cardiovascular and neurodegenerative diseases), as well as cancer. Telomeres are regions of repetitive ... -
Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population
Coltell, Oscar; Asensio, Eva Maria; Sorlí, José V; Barragán-Arnal, Rocío; Fernández-Carrión, Rebeca; Portolés, Olga; CAROLINA, ORTEGA-AZORÍN; Martínez-LaCruz, Raúl; González, José I.; Zanón-Moreno, Vicente; Gimenez Alba, Ignacio Manuel; Fitó, Montserrat; Ros, Emilio; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2019)Although, for decades, increased serum bilirubin concentrations were considered a threatening sign of underlying liver disease and had been associated with neonatal jaundice, data from recent years show that bilirubin is ... -
Impact of the -1438G>A polymorphism in the serotonin 2A receptor gene on anthropometric profile and obesity risk: A case-control study in a Spanish Mediterranean population
Sorlí, José V; Francés, F.; González, José I.; Guillen, Montserrat; Portolés, Olga; Sabater, Antonio; Coltell, Oscar; Corella, Dolores (2008)Research into the genetic factors that regulate food intake is arousing great interest. The polymorphism -1438G>A in the serotonin 2A receptor or 5-hydroxytriptamine (5-HT) type 2A receptor (5-HTR2A) gene has been ... -
In vivo transcriptomic profile after a Mediterranean diet in high–cardiovascular risk patients: a randomized controlled trial
Castañer, Olga; Corella, Dolores; Covas Planells, María Isabel; Subirana, Isaac; Flores Mateo, Gemma; Nonell, Lara; Bulló, Mònica; De la Torre, Rafael; Portolés, Olga; Fitó, Montserrat American Society for Nutrition (2013)Background: Nutrients can exert healthy effects through nutrigenomic modulation. Data are scarce concerning the in vivo effect of a sustained traditional Mediterranean diet (TMD) pattern on the whole transcriptomic ... -
Influence of Demographic and Lifestyle Variables on Plasma Magnesium Concentrations and Their Associations with Cardiovascular Risk Factors in a Mediterranean Population
Barragán-Arnal, Rocío; Llopis, Juan; Portolés, Olga; Sorlí, José V; Coltell, Oscar; Rivas-García, Lorenzo; Asensio, Eva Maria; CAROLINA, ORTEGA-AZORÍN; Corella, Dolores; Sánchez-González, Cristina MDPI (2020)Several studies have shown that a low magnesium (Mg) intake in the diet is associated with greater cardiovascular risk and greater risk of diabetes. However, the results are not consistent in all populations. To minimize ... -
Influence of the adherence to the Mediterranean diet on the effect of smoking on genomewide methylation among subjects with metabolic syndrome
Coltell, Oscar; Asensio, Eva Maria; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; González-Monje, Inma; Pascual, Eva C.; Portolés, Olga; Sáiz, Carmen; Corella, Dolores Heart Centre, University Hospital Halle (Saale) (2019-09-13)Tobacco smoking is an important risk factor for lung cancer, respiratory diseases and cardiovascular diseases, among others. Moreover, smoking can speed up the normal aging process of several tissues increasing the biological ... -
MicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial
Corella, Dolores; Sorlí, José V; Estruch, Ramon; Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Portolés, Olga; Martínez González, Miguel Ángel; Bulló, Mònica; Fitó, Montserrat; Arós, Fernando; Lapetra, José; Asensio, Eva Maria; Sáez Tormo, Guillermo; Serra-Majem, Lluis; Muñoz Bravo, Carlos; Ruiz-Gutiérrez, Valentina; Fiol Ramis, Miquel; Vinyoles, Ernest; Pintó, Xavier; Richardson, Kris; Ros, Emilio; Ordovás Muñoz, José M. American Society for Nutrition (2014-08)Background: MicroRNAs have emerged as important epigenetic regulators in cardiovascular diseases (CVDs). Using an observational meta-analysis design, we previously characterized a gain-of-function microRNA-410 target site ... -
Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic Risk Scores
Corella, Dolores; Coltell, Oscar; Sorlí, José V; Estruch, Ramon; Quiles Guiñau, Laura; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Castañer, Olga; Arós, Fernando; Ortega-Calvo, Manuel; Serra-Majem, Lluis; Gómez Gracia, Enrique; Portolés, Olga; Fiol Ramis, Miquel; Díez Espino, Javier; Basora, Josep; Fitó, Montserrat; Ros, Emilio; Ordovás Muñoz, José M. MDPI (2016)Nutrigenetic studies analyzing gene–diet interactions of the TCF7L2-rs7903146 C > T polymorphism on type-2 diabetes (T2D) have shown controversial results. A reason contributing to this may be the additional modulation by ... -
PPAR-α L162V and PGC-1 G482S gene polymorphisms, but not PPAR-γ P12A, are associated with alcohol consumption in a Spanish Mediterranean population
Francés, F.; Verdú, Fernando; Portolés, Olga; Castello, A.; Sorlí, José V; Guillen, M.; Corella, Dolores Elsevier (2008)Background: Peroxisome Proliferator-Activated Receptors (PPARs) and its co-activators are regulatory elements of the cellular lipid homeostasis and have been associated with feeding behavior modulation. Animal models suggest ... -
Single tube optimisation of APOE genotyping based on melting curve analysis
Francés, F.; Portolés, Olga; Sorlí, José V; Guillen, M.; González, José I.; Corella, Dolores Elsevier (2008)Objectives: To develop and validate a single-tube protocol for APOE genotyping using fluorescent probes. Design and methods: We have designed and validated a hybrid, single-tube, SimpleProbe/FRET probe protocol that takes ... -
Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk
Julibert, Alicia; Bibiloni, Maria del Mar; Bouzas Velasco, Cristina; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Corella, Dolores; Zomeño, Maria Dolors; Romaguera, Dora; Vioque, Jesus; Alonso-Gómez, Ángel M.; Wärnberg, Julia; Martínez, J. Alfredo; Serra-Majem, Lluis; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, José; Pintó, Xavier; López Miranda, José; García-Molina, Laura; Gaforio, Jose J; Matía-Martín, Pilar; Daimiel-Ruiz, Lidia Ángeles; Martín Sánchez, Vicente; Vidal, Josep; Vázquez, Clotilde; Ros, Emili; Toledo, Estefanía; Becerra-Tomás, Nerea; Portolés, Olga; Pérez-Vega, Karla A.; Fiol Ramis, Miquel; Torres-Collado, Laura; Tojal-Sierra, Lucas; Carabaño-Moral, Rosa; Abete, Itziar; Sanchez Villegas, Almudena; Casas, Rosa; Bernal López, María Rosa; Santos Lozano, José Manuel; Galera, Ana; Ugarriza, Lucía; Ruiz-Canela, Miguel; Babio, Nancy; Coltell, Oscar; Schröder, Helmut; Konieczna, Jadwiga; Orozco Beltrán, Domingo; Sorto-Sánchez, Carolina; Eguaras, Sonia; Barrubés, Laura; Fitó, Montserrat; Tur, Josep A.; PREDIMED-PLUS Investigators MDPI (2019)Background: The effect of dietary fat intake on the metabolic syndrome (MetS) and in turn on cardiovascular disease (CVD) remains unclear in individuals at high CVD risk. Objective: To assess the association between fat ...