Browsing by Author "ca088e6f-0190-4c0a-bdc3-2b2f66d1d28d"
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Analysis of basic drugs by liquid chromatography with environmentally friendly mobile phases in pharmaceutical formulations
Peris García, Ester; Ruiz Ángel, M. J.; Carda-Broch, Samuel; García-Álvarez Coque, M. C. Elsevier (2017)Basic drugs are positively charged in the usual working pH (2–8) in reversed-phase liquid chromatography. This gives rise to a strong association with the residual ionized silanols in conventional silica-based stationary ... -
Are analysts doing method validation in liquid chromatography?
Ruiz Ángel, M. J.; García Álvarez-Coque, M. C.; Berthod, A.; Carda-Broch, Samuel (2015-06-22)Method validation is being applied in the reported analytical methods for decades. Even before this protocol was defined, authors already somehow validated their methods without full awareness. They wished to assure the ... -
Chromatographic Efficiency in Micellar Liquid Chromatography: Should it Be Still a Topic of Concern?
Ruiz Ángel, M. J.; Carda-Broch, Samuel; García Álvarez-Coque, M. C. Taylor & Francis (2013)Micellar liquid chromatography (MLC) was first proposed as an attractive alternative to avoid the use of organic solvents. It was soon apparent that pure micellar solutions yield poor efficiencies. This problem was remediated ... -
Extent of the influence of phosphate buffer and ionic liquids on the reduction of the silanol effect in a C18 stationary phase
Carda-Broch, Samuel; García-Álvarez Coque, M. C.; Ruiz Ángel, M. J. Elsevier (2017-06)The presence of anionic free silanols in the silica-based stationary phases gives rise to broad and asymmetrical peaks when cationic basic compounds are chromatographed using hydro-organic mobile phases. The addition to ... -
Half-width plots, a simple tool to predict peak shape, reveal column kinetics and characterise chromatographic columns in liquid chromatography: State of the art and new results
Baeza Baeza, J. J.; Ruiz Ángel, M. J.; García Álvarez-Coque, M. C.; Carda-Broch, Samuel Elsevier (2013-11)Peak profiles in chromatography are characterised by their height, position, width and asymmetry; the two latter depend on the values of the left and right peak half-widths. Simple correlations have been found between the ... -
High submicellar liquid chromatography
Ruiz Ángel, M. J.; Carda-Broch, Samuel; García Álvarez-Coque, M. C. Taylor & Francis (2014-07)Surfactant addition above the critical micellar concentration (CMC), in reversed-phase liquid chromatography (RPLC), was proposed as a way to modify the selectivity and analysis time, giving rise to a chromatographic mode ... -
Modulation of retention and selectivity in oil-in-water microemulsion liquid chromatography: A review
Pankajkumar-Patel, N.; Peris García, Ester; Ruiz Ángel, M. J.; Carda-Broch, Samuel; García-Álvarez Coque, M. C. Elsevier (2019-05)Microemulsions (MEs) are stable, isotropically clear solutions consisting of an oil and water stabilized by a surfactant and a co-surfactant. Oil-in-water microemuslion liquid chromatography (MELC) is a relatively new ... -
On the use of ionic liquids as mobile phase additives in high-performance liquid chromatography. A review
García-Álvarez Coque, M. C.; Ruiz Ángel, M. J.; Berthod, A.; Carda-Broch, Samuel Elsevier (2015-07-07)The popularity of ionic liquids (ILs) has grown during the last decades in several analytical separation techniques. Consequently, the number of reports devoted to the applications of ILs is still increasing. This review ... -
Peak half-width plots to study the effect of organic solvents on the peak performance of basic drugs in micellar liquid chromatography
Ruiz Ángel, M. J.; Carda-Broch, Samuel; García Álvarez-Coque, M. C. Elsevier (2010)The addition of the anionic surfactant sodium dodecyl sulphate (SDS) to hydro-organic mixtures of methanol, ethanol, propanol or acetonitrile with water yielded enhanced peak shape (i.e. increased efficiencies and symmetrical ... -
Performance of different C18 columns in reversed-phase liquid chromatography with hydro-organic and micellar-organic mobile phases
Ruiz Ángel, M. J.; Pous Torres, Sandra; Carda-Broch, Samuel; García Álvarez-Coque, M. C. (2015-06-22)Column selection in reversed-phase liquid chromatography (RPLC) can become a challenge if the target compounds interact with the silica-based packing. One of such interactions is the attraction of cationic solutes to the ... -
Retention mechanisms in micellar liquid chromatography
Ruiz Ángel, M. J.; Carda-Broch, Samuel; Torres Lapasio, José Ramón; García Álvarez-Coque, M. C. Elsevier (2009)Micellar liquid chromatography (MLC) is a reversed-phase liquid chromatographic (RPLC) mode with mobile phases containing a surfactant (ionic or non-ionic) above its critical micellar concentration (CMC). In these conditions, ... -
Submicellar and micellar reversed-phase liquid chromatographic modes applied to the separation of β-blockers
Ruiz Ángel, M. J.; Torres Lapasio, José Ramón; García Álvarez-Coque, M. C.; Carda-Broch, Samuel Elsevier (2009)The behaviour of a reversed-phase liquid chromatographic (RPLC) system (i.e. elution order, resolution and analysis time), used in the analysis of β-blockers with acetonitrile-water mobile phases, changes drastically upon ...