Browsing by Author "c8ba49f1-ec36-49e5-9b35-048a3e47b8bd"
Now showing items 1-16 of 16
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Acetate as an active metabolite of ethanol: studies of locomotion, loss of righting reflex, and anxiety in rodents
Pardo Andrés, Marta; Betz, Adrienne J.; San Miguel Segura, Noemí; López Cruz, Laura; Salamone, John; Correa, Merce Frontiers (2013)It has been postulated that a number of the central effects of ethanol are mediated via ethanol metabolites: acetaldehyde and acetate. Ethanol is known to produce a large variety of behavioral actions such anxiolysis, ... -
Adenosine A2A receptor antagonism and genetic deletion attenuate the effects of dopamine D2 antagonism on effort-based decision making in mice
Pardo Andrés, Marta; López Cruz, Laura; Valverde, Olga; LEDENT, Catherine; Baqi, Younis; Müller, Christa E.; Salamone, John; Correa, Merce Elsevier (2012)Brain dopamine (DA) and adenosine interact in the regulation of behavioral activation and effort-related processes. In the present studies, a T-maze task was developed in mice for the assessment of effort-related decision ... -
Anxiogenic and stress-inducingeffects of peripherally administeredacetaldehyde in mice: Similarities with the disulfiram–ethanol reaction
Escrig, Miguel A.; Pardo Andrés, Marta; González Aragón, Carlos Manuel; Correa, Merce Elsevier (2012)Peripheral accumulation of acetaldehyde, the first metabolite of ethanol, produces autonomic responses in humans called “flushing”. The aversive characteristics of flushing observed in some populations with an isoform of ... -
Choosing voluntary exercise over sucrose consumption depends upon dopamine transmission: effects of haloperidol in wild type and adenosine A2AKO mice
Correa, Merce; Pardo Andrés, Marta; Bayarri Iturralde, Pilar; López Cruz, Laura; San Miguel Segura, Noemí; Valverde, Olga; LEDENT, Catherine; Salamone, John Springer (2016-02)Rationale: Mesolimbic dopamine (DA) regulates behavioral activation and effort-related decision-making in motivated behaviors. Mesolimbic DA D2 receptors are co-localized with adenosine A2A receptors, and they interact in ... -
Conditional neural knockout of the adenosine A2A receptor and pharmacological A2A antagonism reduce pilocarpine-induced tremulous jaw movements: Studies with a mouse model of parkinsonian tremor
Salamone, John; Collins-Praino, Lyndsey E.; Pardo Andrés, Marta; Podurgiel, Samantha J.; Baqi, Younis; Müller, Christa E.; Schwarzschild, Michael A.; Correa, Merce Elsevier (2013)Tremulous jaw movements are rapid vertical deflections of the lower jaw that resemble chewing but are not directed at any particular stimulus. In rats, tremulous jaw movements can be induced by a number of conditions that ... -
Diferencias en memoria, afrontamiento y agresividad entre mujeres futbolistas, no futbolistas y hombres
Pardo Andrés, Marta; Bustamante, Juan Carlos Universitat Jaume I (2005)La idea de pensar que las mujeres que practican fútbol obtienen puntuaciones psicológicas diferenciadas del resto de mujeres, puede tener relevancia para la labor de un psicólogo en el ámbito aplicado. Se han encontrado varios ... -
Differences between the nonselective adenosine receptor antagonists caffeine and theophylline in motor and mood effects: Studies using medium to high doses in animal models
López Cruz, Laura; Pardo Andrés, Marta; Salamone, John; Correa, Merce Elsevier (2014-08)Rationale: Caffeine and theophylline are methylxanthines that are broadly consumed, sometimes at high doses, and act as minor psychostimulants. Both are nonselective adenosine antagonists for A1 and A2A receptors, which ... -
Dopamine, behavioral economics, and effort
Salamone, John; Correa, Merce; Farrar, Andrew M.; Nunes, Eric J.; Pardo Andrés, Marta Frontiers Research Foundation (2009)There are numerous problems with the hypothesis that brain dopamine (DA) systems, particularly in the nucleus accumbens, directly mediate the rewarding or primary motivational characteristics of natural stimuli such as ... -
Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences
Randall, Patrick A.; Pardo Andrés, Marta; Nunes, Eric J.; López Cruz, Laura; Vemuri, Venkata Kiran; Makriyannis, Alexandros; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Public Library of Science (2012)Mesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from food-reinforced tasks with high response ... -
Dosis medias y altas de cafeína no revierten la incoordinación motora producida por alcohol en ratones
San Miguel Segura, Noemí; López Cruz, Laura; Pardo Andrés, Marta; Correa, Merce Universitat Jaume I (2015)En los últimos años, el consumo de las bebidas energéticas ha incrementado notablemente, así como su concentración de cafeína. Con frecuencia, estas bebidas se consumen junto a grandes cantidades de alcohol con el objetivo ... -
Effect of subtype-selective adenosine receptor antagonists on basal or haloperidol-regulated striatal function: Studies of exploratory locomotion and c-Fos immunoreactivity in outbred and A2AR KO mice
Pardo Andrés, Marta; López Cruz, Laura; Valverde, Olga; LEDENT, Catherine; Baqi, Younis; Müller, Christa E.; Salamone, John; Correa, Merce Elsevier (2013-06-15)Behavioral activation is regulated by dopamine (DA) in striatal areas. At low doses, while typical antipsychotic drugs produce psychomotor slowing, psychostimulants promote exploration. Minor stimulants such as caffeine, ... -
Elegir entre consumir dulces o hacer ejercicio depende de la modulación dopaminérgica en el circuito cerebral que regula la motivación
Pardo Andrés, Marta; Bayarri Iturralde, Pilar; López Cruz, Laura; San Miguel Segura, Noemí; Correa, Merce Universitat Jaume I (2015)Introducción: Los organismos continuamente toman decisiones basadas en el valor de los reforzadores y los costes que suponen las respuestas para conseguirlos. La magnitud del esfuerzo que la conducta a ejecutar requiere, ... -
Piecing together the puzzle of acetaldehyde as a neuroactive agent
Correa, Merce; Salamone, John; Segovia, Kristen N.; Pardo Andrés, Marta; Longoni, Rosanna; Spina, Liliana; PEANA, Alessandra Tiziana; Vinci, Stefania; Acquas, Elio Elsevier (2012-01)Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied in the 1940s, but then research interest in this compound waned. However, in the last two decades, research on acetaldehyde has seen ... -
Selection of sucrose concentration depends on the effort required to obtain it: studies using tetrabenazine, D1, D2, and D3 receptor antagonists
Pardo Andrés, Marta; López Cruz, Laura; San Miguel Segura, Noemí; Salamone, John; Correa, Merce Springer Verlag (2015)Rationale Low doses of dopamine (DA) antagonists and accumbens DA depletions reduce food-reinforced instrumental behavior but do not impair primary food motivation, causing animals to reallocate behavior away from ... -
The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond
Salamone, John; Correa, Merce; Nunes, Eric J.; Randall, Patrick A.; Pardo Andrés, Marta Wiley (2012-01)For many years, it has been suggested that drugs that interfere with dopamine (DA) transmission alter the “rewarding” impact of primary reinforcers such as food. Research and theory related to the functions of mesolimbic ... -
The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: Implications for pharmacological models of parkinsonian tremor
López Cruz, Laura; Podurgiel, Samantha J.; Nunes, Eric J.; Yohn, Samantha E.; Barber, J.; Thompson, A.; Milligan, M.; Lee, Christie A.; Pardo Andrés, Marta; Valverde, Olga; LEDENT, Catherine; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Elsevier (2013)Tetrabenazine (TBZ) is a reversible inhibitor of vesicular monoamine storage that is used to treat Huntington’s disease. TBZ preferentially depletes striatal dopamine (DA), and patients being treated with TBZ often experience ...