Listar por autoría "bc4214a3-0126-4f20-baab-c43e3e41d229"
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Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules
Marco, J. Alberto; García Pla, Jorge; Carda, Miguel; Murga, Juan; Falomir, Eva; Trigili, Chiara; Notararigo, Sara; Díaz, J. Fernando; Barasoain, Isabel Elsevier (2011-05)The preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active than ... -
Synthesis and Biological Evaluation As Microtubule-Active Agents of Several Tetrahydrofuran and Spiroacetal Derivatives
Carda, Miguel; Murga, Juan; Angulo-Pachón, César A.; García Pla, Jorge; Diaz-Oltra, Santiago; Marco, J. Alberto; Trigili, Chiara; Redondo Horcajo, Mariano; Díaz, J. Fernando; Barasoain, Isabel Bentham Science (2013)The stereoselective preparation of several molecules containing structural fragments of the tetrahydrofuran and spiroacetal type is described. Their degree of cytotoxicity and their interactions with tubulin have been ... -
Synthesis and Biological Evaluation of a-Tubulin-Binding Pironetin Analogues with Enhanced Lipophilicity
Carda, Miguel; Murga, Juan; Falomir, Eva; Diaz-Oltra, Santiago; García Pla, Jorge; Paños Pérez, Julián; Trigili, Chiara; Díaz, J. Fernando; Barasoain, Isabel; Marco, J. Alberto Wiley-VCH Verlag (2013)The preparation of four new lipophilic analogues of the natural pyrone pironetin is described. The nine-carbon side chain of the latter has been replaced in one analogue by a 4-phenylbutyl chain and in the other three ...