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Acetate as an active metabolite of ethanol: studies of locomotion, loss of righting reflex, and anxiety in rodents
Pardo Andrés, Marta; Betz, Adrienne J.; San Miguel Segura, Noemí; López Cruz, Laura; Salamone, John; Correa, Merce Frontiers (2013)It has been postulated that a number of the central effects of ethanol are mediated via ethanol metabolites: acetaldehyde and acetate. Ethanol is known to produce a large variety of behavioral actions such anxiolysis, ... -
Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology
Salamone, John; Yohn, Samantha E.; López Cruz, Laura; San Miguel Segura, Noemí; Correa, Merce Oxford University Press (2016-04-26)Motivation has been defined as the process that allows organisms to regulate their internal and external environment, and control the probability, proximity and availability of stimuli. As such, motivation is a complex ... -
Adenosine A2A receptor antagonism and genetic deletion attenuate the effects of dopamine D2 antagonism on effort-based decision making in mice
Pardo Andrés, Marta; López Cruz, Laura; Valverde, Olga; LEDENT, Catherine; Baqi, Younis; Müller, Christa E.; Salamone, John; Correa, Merce Elsevier (2012)Brain dopamine (DA) and adenosine interact in the regulation of behavioral activation and effort-related processes. In the present studies, a T-maze task was developed in mice for the assessment of effort-related decision ... -
Adenosine A2A receptor deletion affects social behaviors and anxiety in mice: Involvement of anterior cingulate cortex and amygdala
López Cruz, Laura; Carbó Gas, María; Pardo, Marta; Bayarri Iturralde, Pilar; Valverde, Olga; LEDENT, Catherine; Salamone, John; Correa, Merce Elsevier (2017)Blockade of adenosine A2A receptors can potentiate motivation to work for natural reinforcers such as food. Conspecific interaction is a potent natural reinforcer in social animals that can be manifested as preference for ... -
Anxiogenic and stress-inducingeffects of peripherally administeredacetaldehyde in mice: Similarities with the disulfiram–ethanol reaction
Escrig, Miguel A.; Pardo Andrés, Marta; González Aragón, Carlos Manuel; Correa, Merce Elsevier (2012)Peripheral accumulation of acetaldehyde, the first metabolite of ethanol, produces autonomic responses in humans called “flushing”. The aversive characteristics of flushing observed in some populations with an isoform of ... -
Assessment of a glycine uptake inhibitor in animal models of effort-related choice behavior: implications for motivational dysfunctions
Yohn, Samantha E.; Alberati, Daniela; Correa, Merce; Salamone, John Springer Verlag (2017)Rationale Motivated behavior can be characterized by a substantial exertion of effort, and organisms often make effortrelated decisions based upon analyses of work-related response costs and reinforcement preference. ... -
Assessment of a glycine uptake inhibitor in animal models of effort-related choice behavior: implications for motivational dysfunctions
Yohn, Samantha E.; Alberati, Daniela; Correa, Merce; Salamone, John Springer Verlag (2017)Rationale Motivated behavior can be characterized by a substantial exertion of effort, and organisms often make effortrelated decisions based upon analyses of work-related response costs and reinforcement preference. ... -
Behavioral and dopamine transporter binding properties of the modafinil analog (S, S)-CE-158: reversal of the motivational effects of tetrabenazine and enhancement of progressive ratio responding
Rotolo, Renee; Kalaba, Predrag; Dragacevic, Vladimir; Presby, Rose; Neri, Julia; Robertson, Emily; Yang, Jen-Hau; Correa, Merce; Bakulev, Vasiliy; Volkova, Natalia N.; Pifl, Christian; Lubec, Gert; Salamone, John Springer (2020)Rationale Atypical dopamine (DA) transport blockers such as modafinil and its analogs may be useful for treating motivational symptoms of depression and other disorders. Previous research has shown that the DA depleting ... -
Blockade of uptake for dopamine, but not norepinephrine or 5-HT, increases selection of high effort instrumental activity: Implications for treatment of effort-related motivational symptoms in psychopathology
Yohn, Samantha E.; Errante, Emily E.; Rosenbloom Snow, Aaron; Somerville, Matthew; Rowland, Margaret; Tokarski, Kristin; Zafar, Nadia; Correa, Merce; Salamone, John Elsevier (2016)Deficits in behavioral activation, exertion of effort, and other psychomotor/motivational symptoms are frequently seen in people with depression and other disorders. Depressed people show a decision bias towards selection ... -
c-Fos immunoreactivity in prefrontal, basal ganglia and limbic areas of the rat brain after central and peripheral administration of ethanol and its metabolite acetaldehyde
Segovia, Kristen N.; Vontell, Regina; López Cruz, Laura; Salamone, John; Correa, Merce Frontiers (2013)Considerable evidence indicates that the metabolite of ethanol (EtOH), acetaldehyde, is biologically active. Acetaldehyde can be formed from EtOH peripherally mainly by alcohol dehydrogenase (ADH), and also centrally by ... -
Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression
López Cruz, Laura; Salamone, John; Correa, Merce Frontiers Media (2018-06-01)Major depressive disorder is one of the most common and debilitating psychiatric disorders. Some of the motivational symptoms of depression, such anergia (lack of self-reported energy) and fatigue are relatively resistant ... -
Caffeine Modulates Food Intake Depending on the Context That Gives Access to Food: Comparison With Dopamine Depletion
Correa, Merce; San Miguel Segura, Noemí; López Cruz, Laura; Carratalá-Ros, Carla; Olivares-García, Régulo; Salamone, John (2018-09-06)Caffeine is a methylxanthine consumed in different context s to potentiate alertness and reduce fatigue. However, caffeine can induce anxiety at hig h doses. Caffeine is also a minor psychostimulant that seems to act ... -
Caffeine modulates voluntary alcohol intake in mice depending on theaccess conditions: Involvement of adenosine receptors and the role of individual differences
San Miguel Segura, Noemí; López Cruz, Laura; Müller, Christa E.; Salomone, John D.; Correa, Merce Elsevier (2019)Caffeine is the most consumed psychoactive stimulant and the main active ingredient of energy drinks.Epidemiology studies have shown a positive correlation between the consumption of energy drinks and that ofethanol. The ... -
Caffeine modulation of alcohol intake: impact on its psychomotor effects and withdrawal
Correa, Merce; SanMiguel, Noemí; López Cruz, Laura; Bayarri Iturralde, Pilar; Monferrer, Lidón; Salamone, John Nova Science Publishers (2014-04)Caffeine is a natural substance that is present in over 60 plant species. Alternative names include theine, guaranine and mateine. It is consumed by humans in the form of beverages such as coffee, tea, chocolate and soft ... -
Changes in nucleus accumbens and neostriatal c-Fos and DARPP-32 immunoreactivity during different stages of food-reinforced instrumental training
Segovia, Kristen N.; Correa, Merce; Lennington, Jessica B.; Conover, Joanne C.; Salamone, John Blackwells Publishing (2012)Nucleus accumbens is involved in several aspects of instrumental behavior, motivation and learning. Recent studies showed that dopamine (DA) release in the accumbens shell was significantly increased on the first day of ... -
Choosing voluntary exercise over sucrose consumption depends upon dopamine transmission: effects of haloperidol in wild type and adenosine A2AKO mice
Correa, Merce; Pardo Andrés, Marta; Bayarri Iturralde, Pilar; López Cruz, Laura; San Miguel Segura, Noemí; Valverde, Olga; LEDENT, Catherine; Salamone, John Springer (2016-02)Rationale: Mesolimbic dopamine (DA) regulates behavioral activation and effort-related decision-making in motivated behaviors. Mesolimbic DA D2 receptors are co-localized with adenosine A2A receptors, and they interact in ... -
Comparación de dosis altas de las metilxantinas cafeína y teofilina en efectos motores y ansiogénicos: estudio en modelos animales
López Cruz, Laura; Pardo, Marta; Dosda, Alicia; Salomone, John D.; Correa, Merce Universitat Jaume I (2011)La cafeína y la teofilina son metilxantinas que actúan como antagonistas no selectivos de la adenosina, activando dos tipos de receptores adenosinérgicos presentes en el sistema nervioso central: los A1 y los A2A. ... -
Complexities and paradoxes in understanding the role of dopamine in incentive motivation and instrumental action: Exertion of effort vs. anhedonia
Salamone, John; Ecevitoglu, Alev; Carratalá-Ros, Carla; Presby, Rose; Edelstein, Gayle A; Fleeher, Reileigh; Rotolo, Renee; Meka, Nicolette; Srinath, Sonya; Masthay, Jamie C.; Correa, Merce Elsevier (2022-05)Instrumental behavior is a very complex and multifaceted process. Behavioral output during instrumental performance is influenced by a variety of factors, including associative conditioning, directional and activational ... -
Conditional neural knockout of the adenosine A2A receptor and pharmacological A2A antagonism reduce pilocarpine-induced tremulous jaw movements: Studies with a mouse model of parkinsonian tremor
Salamone, John; Collins-Praino, Lyndsey E.; Pardo Andrés, Marta; Podurgiel, Samantha J.; Baqi, Younis; Müller, Christa E.; Schwarzschild, Michael A.; Correa, Merce Elsevier (2013)Tremulous jaw movements are rapid vertical deflections of the lower jaw that resemble chewing but are not directed at any particular stimulus. In rats, tremulous jaw movements can be induced by a number of conditions that ... -
¿Cómo afectan las experiencias tempranas en la vida a nuestro cerebro y a nuestra motivación?
Matas-Navarro, Paula; Correa, Merce Publicacions de la Universitat Jaume I. Servei de Comunicació i Publicacions (2023)