Listar por autoría "9ff770c4-ea13-43d5-8c68-8f753c81b3b4"
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Efavirenz and the CNS: what we already know and questions that need to be answered
Apostolova, Nadezda; Funes, Haryes A.; Blas García, Ana; Galindo, Maria J.; Álvarez, Ángeles; Esplugues, Juan V. Oxford University Press (2015-07)The NNRTI efavirenz has long been one of the most frequently employed antiretroviral drugs in the multidrug regimens used to treat HIV infection, in accordance with its well-demonstrated antiretroviral efficacy and ... -
ER stress in human hepatic cells treated with Efavirenz: Mitochondria again
Apostolova, Nadezda; Gómez Sucerquia, Leysa J.; Alegre, Fernando; Funes, Haryes A.; Víctor, Víctor M.; Barrachina Sancho, María Dolores; Blas García, Ana; Esplugues Mota, Juan V. Elsevier (2013-10)Background & Aims ER stress is associated with a growing number of liver diseases, including drug-induced hepatotoxicity. The non-nucleoside analogue reverse transcriptase inhibitor Efavirenz, a cornerstone of the ... -
Involvement of nitric oxide in the mitochondrial action of efavirenz: a differential effect on neurons and glial cells
Apostolova, Nadezda; Funes, Haryes A.; Blas García, Ana; Alegre, Fernando; Polo, Míriam; Esplugues Mota, Juan V. Oxford University Press (2014-12)The anti-human immunodeficiency virus (HIV) drug efavirenz (EFV) alters mitochondrial function in cultured neurons and glial cells. Nitric oxide (NO) is a mediator of mitochondrial dysfunction associated with HIV central ... -
Mitochondrial (dys)function-a factor underlying the variability of EFV-induced hepatoxicity?
Polo, Míriam; Alegre, Fernando; Funes, Haryes A.; Blas García, Ana; Víctor, Víctor M.; Esplugues Mota, Juan V.; Apostolova, Nadezda Wiley (2015-01-08)Background and PurposeThe non-nucleoside analogue reverse transcriptase inhibitor efavirenz is associated with hepatic toxicity and metabolic disturbances. Although the mechanisms involved are not clear, recent evidence ... -
Neuronal Bioenergetics and Acute Mitochondrial Dysfunction: A Clue to Understanding the Central Nervous System Side Effects of Efavirenz
Funes, Haryes A.; Apostolova, Nadezda; Alegre, Fernando; Blas García, Ana; Álvarez, Ángeles; Martí Cabrera, Miguel; Esplugues Mota, Juan V. Oxford University Press (2014-05)Background. Neurological pathogenesis is associated with mitochondrial dysfunction and differences in neuronal/glial handling of oxygen and glucose. The main side effects attributed to efavirenz involve the CNS, but the ... -
The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction
Blas García, Ana; Martí Rodrigo, Alberto; Víctor, Víctor M.; Polo, Míriam; Alegre, Fernando; Funes, Haryes A.; Apostolova, Nadezda; Esplugues Mota, Juan V. Oxford University Press (2016-01-07)Background NRTIs are essential components of HIV therapy with well-documented, long-term mitochondrial toxicity in hepatic cells, but whose acute effects on mitochondria are unclear. As acetaminophen-induced hepatotoxicity ...