Browsing by Author "9d684c81-d372-4483-b53f-092847f5a5a2"
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Amino acid change in the carbohydrate response element binding protein is associated with lower triglycerides and myocardial infarction incidence depending on level of adherence to the Mediterranean diet in the PREDIMED trial
CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Estruch, Ramon; Asensio, Eva Maria; Coltell, Oscar; González, José I.; Martínez González, Miguel Ángel; Ros, Emilio; Salas-Salvadó, Jordi; Fitó, Montserrat; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Ruiz-Gutiérrez, Valentina; Gómez Gracia, Enrique; Fiol Ramis, Miquel; Flores, Gemma; Pintó, Xavier; Sáiz, Carmen; Ordovás Muñoz, José M.; Corella, Dolores American Heart Association (2014-02)Background: A variant (rs3812316, C771G, Gln241His) in the MLXIPL (Max-like protein X interacting protein-like) gene encoding the carbohydrate response element binding protein has been associated with lower triglycerides. ... -
Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulate by diet, being higher when adherence to the Mediterranean diet pattern is low
Coltell, Oscar; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Gómez Gracia, Enrique; Fiol Ramis, Miquel; Sáez Tormo, Guillermo; Pintó, Xavier; Muñoz, Miguel Ángel; Ordovás Muñoz, José M.; Estruch, Ramon; Corella, Dolores; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Asensio, Eva Maria; Covas Planells, María Isabel; Ros, Emilio BioMed Central (2012-11)Background: Although the Fat Mass and Obesity (FTO) and Melanocortin-4 Receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is ... -
Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects
Barragán-Arnal, Rocío; Coltell, Oscar; Portolés, Olga; Asensio, Eva Maria; Sorlí, José V; CAROLINA, ORTEGA-AZORÍN; González, José I.; Sáiz, Carmen; Fernández-Carrión, Rebeca; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2018)There is growing interest in relating taste perception to diet and healthy aging. However, there is still limited information on the influence of age, sex and genetics on taste acuity as well as on the relationship between ... -
Candidate Gene and Genome-Wide Association Studies for Circulating Leptin Levels Reveal Population and Sex-Specific Associations in High Cardiovascular Risk Mediterranean Subjects
CAROLINA, ORTEGA-AZORÍN; Coltell, Oscar; Asensio, Eva Maria; Sorlí, José V; González, José I.; Portolés, Olga; Saiz, Carmen; Estruch, Ramon; Ramírez-Sabio, Judith B.; Pérez-Fidalgo, J. Alejandro; Ordovas, Jose; Corella, Dolores MDPI (2019)Leptin is a hormone crucial in the regulation of food intake and body-weight maintenance. However, the genes and gene variants that influence its plasma levels are still not well known. Results of studies investigating ... -
CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial
Corella, Dolores; Asensio, Eva Maria; Coltell, Oscar; Sorlí, José V; Estruch, Ramon; Martínez González, Miguel Ángel; Castañer, Olga; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Gómez Gracia, Enrique; CAROLINA, ORTEGA-AZORÍN; Fiol Ramis, Miquel; Díez Espino, Javier; Díaz López, Andrés; Fitó, Montserrat; Ros, Emilio; Ordovás Muñoz, José M. BioMed Central (2016-01)Background Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by ... -
Crosstalk between smoking and the genome in older subjects with metabolic syndrome through genomics, epigenomics and transcriptomics
Coltell, Oscar; Asensio, Eva Maria; CAROLINA, ORTEGA-AZORÍN; Barragán-Arnal, Rocío; Sáiz, Carmen; Portolés, Olga; Sorlí, José V; Corella, Dolores European Molecular Biology Organization (EMBO) (2019-09-11)Tobacco smoking (Figure 1) is a major cause of cardiovascular diseases (CVD), and appears to have a multiplicative interaction with the other major CVD risk factors (lipids, hypertension, diabetes and others present in the ... -
Genome-wide association analyses of weight loss in a randomized controlled trial of lifestyle intervention, and combined transcriptome-wide associations in a Mediterranean population
Corella, Dolores; Asensio, Eva Maria; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Fernández-Carrión, Rebeca; Barragán-Arnal, Rocío; González, José I.; Coltell, Oscar European Molecular Biology Organization (EMBO) (2019-09-11)Although large-scale genome-wide association studies (GWAS) for obesity traits have identified more than 400 associated loci from observational studies (Figure 1), we highlight the fact that currently the number of GWAS ... -
Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population
Coltell, Oscar; Asensio, Eva Maria; Sorlí, José V; Barragán-Arnal, Rocío; Fernández-Carrión, Rebeca; Portolés, Olga; CAROLINA, ORTEGA-AZORÍN; Martínez-LaCruz, Raúl; González, José I.; Zanón-Moreno, Vicente; Gimenez Alba, Ignacio Manuel; Fitó, Montserrat; Ros, Emilio; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2019)Although, for decades, increased serum bilirubin concentrations were considered a threatening sign of underlying liver disease and had been associated with neonatal jaundice, data from recent years show that bilirubin is ... -
Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome
Coltell, Oscar; Sorlí, José V; Asensio, Eva Maria; Barragán-Arnal, Rocío; González, José I.; Gimenez Alba, Ignacio Manuel; Zanón-Moreno, Vicente; Estruch, Ramon; Ramírez-Sabio, Judith B.; Pascual, Eva C.; CAROLINA, ORTEGA-AZORÍN; Ordovas, Jose; Corella, Dolores MDPI (2020)Many early studies presented beneficial effects of polyunsaturated fatty acids (PUFA) on cardiovascular risk factors and disease. However, results from recent meta-analyses indicate that this effect would be very low or ... -
Influence of Demographic and Lifestyle Variables on Plasma Magnesium Concentrations and Their Associations with Cardiovascular Risk Factors in a Mediterranean Population
Barragán-Arnal, Rocío; Llopis, Juan; Portolés, Olga; Sorlí, José V; Coltell, Oscar; Rivas-García, Lorenzo; Asensio, Eva Maria; CAROLINA, ORTEGA-AZORÍN; Corella, Dolores; Sánchez-González, Cristina MDPI (2020)Several studies have shown that a low magnesium (Mg) intake in the diet is associated with greater cardiovascular risk and greater risk of diabetes. However, the results are not consistent in all populations. To minimize ... -
Influence of the adherence to the Mediterranean diet on the effect of smoking on genomewide methylation among subjects with metabolic syndrome
Coltell, Oscar; Asensio, Eva Maria; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; González-Monje, Inma; Pascual, Eva C.; Portolés, Olga; Sáiz, Carmen; Corella, Dolores Heart Centre, University Hospital Halle (Saale) (2019-09-13)Tobacco smoking is an important risk factor for lung cancer, respiratory diseases and cardiovascular diseases, among others. Moreover, smoking can speed up the normal aging process of several tissues increasing the biological ... -
Metabolites, genomics, epigenomics, exposomics and health: Focus on serum bilirubin concentrations in subjects with metabolic syndrome from a Mediterranean population
Coltell, Oscar; Asensio, Eva Maria; Barragán-Arnal, Rocío; Sorlí, José V; Corella, Dolores Gordon Research Conferences (2019-02-03)Although metabolomics aims at the measurement of small molecules (metabolites) in a biological sample, this knowledge requires additional information on the related genetic variants, epigenetic regulators and environmental ... -
MicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial
Corella, Dolores; Sorlí, José V; Estruch, Ramon; Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Portolés, Olga; Martínez González, Miguel Ángel; Bulló, Mònica; Fitó, Montserrat; Arós, Fernando; Lapetra, José; Asensio, Eva Maria; Sáez Tormo, Guillermo; Serra-Majem, Lluis; Muñoz Bravo, Carlos; Ruiz-Gutiérrez, Valentina; Fiol Ramis, Miquel; Vinyoles, Ernest; Pintó, Xavier; Richardson, Kris; Ros, Emilio; Ordovás Muñoz, José M. American Society for Nutrition (2014-08)Background: MicroRNAs have emerged as important epigenetic regulators in cardiovascular diseases (CVDs). Using an observational meta-analysis design, we previously characterized a gain-of-function microRNA-410 target site ... -
MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population
Barragán-Arnal, Rocío; Coltell, Oscar; Asensio, Eva Maria; Francés, Francesc; Sorlí, José V; Estruch, Ramon; Salas Huetos, Albert; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2016)Recently, microRNAs (miRNA) have been proposed as regulators in the different processes involved in alcohol intake, and differences have been found in the miRNA expression profile in alcoholics. However, no study has ... -
The Gln241His polymorphism in the carbohydrate response element binding protein (MLXIPL) gene
CAROLINA, ORTEGA-AZORÍN; Carrasco, Paula; Sorlí, José V; Coltell, Oscar; Asensio, Eva Maria; Luna, C.; González, José I.; Corella, Dolores Nature Publishing Group (2009-06) -
Ultra-Performance Liquid Chromatography-Ion Mobility Separation-Quadruple Time-of-Flight MS (UHPLC-IMS-QTOF MS) Metabolomics for Short-Term Biomarker Discovery of Orange Intake: A Randomized, Controlled Crossover Study
Lacalle-Bergeron, Leticia; Portoles, Tania; López, Francisco J.; Sancho, Juan V; CAROLINA, ORTEGA-AZORÍN; Asensio, Eva Maria; Coltell, Oscar; Corella, Dolores MDPI (2020)A major problem with dietary assessments is their subjective nature. Untargeted metabolomics and new technologies can shed light on this issue and provide a more complete picture of dietary intake by measuring the profile ... -
Untargeted metabolomics based on ultra-high-performance liquid chromatography-ion mobility-quadrupole time-of-flight mass spectrometry for biomarker discovery of orange intake in a cross-over trial
Portoles, Tania; Coltell, Oscar; Lacalle-Bergeron, Leticia; Sancho, Juan V; Lopez, Francisco; CAROLINA, ORTEGA-AZORÍN; Asensio, Eva Maria; Corella, Dolores Gordon Research Conferences (2019-02-03)Diet is one of the most important lifestyle factors associated with health status. Currently, one of the main limitations of nutritional epidemiology and nutritional genomics is the difficulty in the measurements of dietary ...