Listar por autoría "978b7dee-2a37-49f5-94dd-6c9b47bc6c95"
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AAV delivery of shRNA against IRS1 in GABAergic neurons in rat hippocampus impairs spatial memory in females and male rats
Sánchez-Sarasúa, Sandra; Ribes-Navarro, Alberto; Beltrán Bretones, María Teresa; Sánchez-Pérez, Ana María Springer (2020-11-27)Brain insulin resistance is a major factor leading to impaired cognitive function and it is considered as the onset of Alzheimer´s disease. Insulin resistance is intimately linked to inflammatory conditions, many studies ... -
Abscisic Acid Supplementation Rescues High Fat Diet-Induced Alterations in Hippocampal Inflammation and IRSs Expression
Ribes-Navarro, Alberto; Atef, Mariam; Sánchez-Sarasúa, Sandra; Beltrán Bretones, María Teresa; Olucha-Bordonau, Francisco E; Sánchez-Pérez, Ana María Springer (2018)Accumulated evidence indicates that neuroinflammation induces insulin resistance in the brain. Moreover, both processes are intimately linked to neurodegenerative disorders, including Alzheimer’s disease. Potential mechanisms ... -
Can We Treat Neuroinflammation in Alzheimer's Disease?
Sánchez-Sarasúa, Sandra; Fernández-Pérez, Iván; Espinosa-Fernández, Verónica; Sánchez-Pérez, Ana María; Ledesma, Juan Carlos MDPI (2020-11-19)Alzheimer’s disease (AD), considered the most common type of dementia, is characterized by a progressive loss of memory, visuospatial, language and complex cognitive abilities. In addition, patients often show comorbid ... -
Central relaxin-3 receptor (RXFP3) activation impairs social recognition and modulates ERK-phosphorylation in specific GABAergic amygdala neurons
Albert Gasco, Hector; Sánchez-Sarasúa, Sandra; Ma, Sherie; García Díaz, Cristina; Gundlach, Andrew Lawrence; Sánchez-Pérez, Ana María; Olucha-Bordonau, Francisco E Springer (2019-01)In mammals, the extended amygdala is a neural hub for social and emotional information processing. In the rat, the extended amygdala receives inhibitory GABAergic projections from the nucleus incertus (NI) in the pontine ... -
Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons and impairs spatial working memory.
Albert Gasco, Hector; García Avilés, Álvaro; Moustafa, S.; Sánchez-Sarasúa, Sandra; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E; Sánchez-Pérez, Ana María Springer (2016-05-05)The medial septum/diagonal band (MS/DB) is a relay region connecting the hypothalamus and brainstem with the hippocampus, and both the MS/DB and dorsal/ventral hippocampus receive strong topographic GABA/peptidergic ... -
Design, Synthesis and Evaluation of Fluorescent Analogues of Abscisic Acid
González, Florenci; Bou Iserte, Lledó; Miguel-López, Borja; de la hoz rodriguez, Sergio; Kersten, Christian; Sánchez-Sarasúa, Sandra; Espinosa-Fernández, Verónica; Sánchez-Pérez, Ana María Wiley (2020-07-13)A fluorescent analogue of abscisic acid has been prepared by combining (S)‐abscisic acid (ABA) with nitrobenzoxadiazole (NBD) fluorophore using ethanol amine as a linker. Isomerization of the double bond at the side chain ... -
Extinción de memorias condicionadas asociadas a la administración de drogas de abuso
Sánchez-Sarasúa, Sandra Universitat Jaume I (2014-07-22)Las señales contextuales previamente asociadas al consumo de una droga juegan un papel fundamental en el “craving” o deseo de volver a consumir y, por tanto, en las recaídas. Se han desarrollado estrategias, como la ... -
IRS1 expression in hippocampus is age-dependent and is required for mature spine maintenance and neuritogenesis
Sánchez-Sarasúa, Sandra; Meseguer Beltrán, Maria; García Díaz, Cristina; Beltrán-Bretones, Maria Teresa; ElMlili, Nisrin; Sánchez-Pérez, Ana María Elsevier (2022-01)Insulin and insulin-like growth factor type I (IGF-1) play prominent roles in brain activity throughout the lifespan. Insulin/IGF1 signaling starts with the activation of the intracellular insulin receptor substrates (IRS). ... -
Nucleus incertus ablation disrupted conspecific recognition and modified immediate early gene expression patterns in ‘social brain’ circuits of rats
García Díaz, Cristina; Sánchez-Catalán, María José; Castro-Salazar, E.; García Avilés, Álvaro; Albert Gasco, Hector; Sánchez-Sarasúa, Sandra; Sánchez-Pérez, Ana María; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Elsevier (2019-01-01)Social interaction involves neural activity in prefrontal cortex, septum, hippocampus, amygdala and hypothalamus. Notably, these areas all receive projections from the nucleus incertus (NI) in the pontine tegmentum. ... -
P2X4 signalling contributes to hyperactivity but not pain sensitization comorbidity in a mouse model of attention deficit/hyperactivity disorder
Bou Sader Nehme, Sarah; Sánchez-Sarasúa, Sandra; adel, ramy; Tuifua, Marie; Ali, Awatef; Essawy, Amina; Abdel Salam, Sherine; Hleihel, Walid; Boué-Grabot, Eric; Landry, Marc Frontiers Media (2024)Introduction: Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by hyperactivity, inattention, and impulsivity that often persist until adulthood. Frequent comorbid ... -
Targeting Neuroinflammation with Abscisic Acid Reduces Pain Sensitivity in Females and Hyperactivity in Males of An ADHD Mice Model
Meseguer Beltrán, Maria; Sánchez-Sarasúa, Sandra; Landry, Marc; Kerekes, Nóra; Sánchez-Pérez, Ana María MDPI (2023-01-31)Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental syndrome characterized by dopaminergic dysfunction. In this study, we aimed to demonstrate that there is a link between dopaminergic deficit and ... -
The effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammation
Sánchez-Sarasúa, Sandra; Moustafa, S.; García Avilés, Álvaro; López Climent, María Fernanda; Gomez-Cadenas, Aurelio; Olucha-Bordonau, Francisco E; Sánchez-Pérez, Ana María BioMed Central (2016-10)Background Western diet and lifestyle are associated with overweight, obesity, and type 2 diabetes, which, in turn, are correlated with neuroinflammation processes. Exercise and a healthy diet are important in the ...