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Carga de hospitalizaciones recurrentes tras una hospitalización por insuficiencia cardiaca aguda: insuficiencia cardiaca con función sistólica conservada frente a reducida
Santas, Enrique; Valero, Ernesto; Mollar, Anna; García-Blas, Sergio; Palau, Patricia; Miñana, Gema; Núñez, Eduardo; Sanchis, Juan; Chorro, Francisco J.; Núñez, Julio Elsevier (2016-11)Introduction and objectives: Heart failure with preserved ejection fraction and reduced ejection fraction share a high mortality risk. However, differences in the rehospitalization burden over ti ... -
Differential prognostic impact of type 2 diabetes mellitus in women and men with heart failure with preserved ejection fraction
Palau, Patricia; Bertomeu-González, Vicente; Sanchis, Juan; Soler Costa, Meritxell; De la Espriella, Rafael; Domínguez Mafé, Eloy; Santas, Enrique; Núñez, Eduardo; Chorro, Francisco J.; Miñana, Gema; Bayes-Genis, Antoni; Núñez, Julio Elsevier (2019)Introduction and objectives Type 2 diabetes mellitus (DM2) is a common comorbidity in patients with heart failure (HF) with preserved ejection fraction (HFpEF). Previous studies have shown that diabetic women are at ... -
Early effects of empagliflozin on exercise tolerance in patients with heart failure: A pilot study.
Núñez, Julio; Palau, Patricia; Domínguez Mafé, Eloy; Mollar, Anna; Núñez, Eduardo; Ramón, José María; Miñana, Gema; Santas, Enrique; Facila Rubio, Lorenzo; Górriz, José Luis; Sanchis, Juan; Bayes-Genis, Antoni Wiley (2018-04-17)Background: Sodium-glucose linked transporter 2 inhibition recently emerged as a promising ther- apy for reducing the risk of heart failure (HF) in patients with type 2 diabetes mellitus (T2DM). However, there is a lack ... -
Early glomerular filtration rate decline is associated with hemoglobin rise following dapagliflozin initiation in heart failure with reduced ejection fraction
Miñana, Gema; De la Espriella, Rafael; Palau, Patricia; Amiguet Comins, Martina; Seller, Julia; García Pinilla, José Manuel; Núñez, Eduardo; Górriz, José Luis; Valle, Alfonso; Sanchis, Juan; Bayés-Genís, Antoni; Núñez, Julio; DAPA-VO2 Investigators, / Elsevier (2023)Introduction and objectives Sodium-glucose cotransporter-2 inhibitors (SGLT2i) induce short-term changes in renal function and hemoglobin. Their pathophysiology is incompletely understood. We aimed to evaluate the ... -
Heart rate response and functional capacity in patients with chronic heart failure with preserved ejection fraction
Domínguez Mafé, Eloy; Palau, Patricia; Núñez, Eduardo; Ramón, José María; López, Laura; Melero, Joana; Bellver, Alejandro; Santas, Enrique; Chorro, Francisco J.; Núñez, Julio Wiley (2018)Aims: The mechanisms of exercise intolerance in heart failure with preserved ejection fraction (HFpEF) are not yet elucidated. Chronotropic incompetence has emerged as a potential mechanism. We aimed to evaluate whether ... -
Inspiratory Muscle Function and Exercise Capacity in Patients with Heart Failure with Preserved Ejection Fraction
Palau, Patricia; Domínguez Mafé, Eloy; Núñez, Eduardo; Ramón, José María; López, Laura; Melero, Joana; Bellver, Alejandro; Chorro, Francisco J.; Bodí, Vicent; Bayes-Genis, Antoni; Sanchis, Juan; Núñez, Julio Elsevier (2017-06)Background Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome characterized by impaired exercise capacity resulting from dyspnea and fatigue. The pathophysiological mechanisms underlying the ... -
Iron deficiency and short-term adverse events in patients with decompensated heart failure
Palau, Patricia; Llàcer, Pau; Domínguez Mafé, Eloy; Tormo, Juan Pablo; Zakarne, Rim; Mollar, Anna; Martínez, Ana; Miñana, Gema; Santas, Enrique; Almenar-Bonet, Luis; Fácila, Lorenzo; de la Espriella-Juan, Rafael; Núñez, Eduardo; Manzano, Luis; Bayes-Genis, Antoni; Núñez, Julio Springer (2021-03-15)Background: For patients with heart failure (HF), iron deficiency (ID) is a common therapeutic target. However, little is known about the utility of transferrin saturation (TSAT) or serum ferritin for risk stratification ... -
Plasma neutrophil gelatinase-associated lipocalin and long-term mortality in patients with acute heart failure and normal renal function
Miñana, Gema; Rumiz, Eva; Palau, Patricia; Valero, Ernesto; Bodí, Vicent; Núñez, Eduardo; Sanchis, Juan; Núñez, Julio Elsevier (2016)Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a renal tubular marker for early renal dysfunction [1]. Recent studies highlighted its role in predicting acute kidney injury (AKI) and clinical outcomes in ... -
Procalcitonin and long-term prognosis after an admission for acute heart failure
Villanueva, María Pilar; Mollar, Anna; Palau, Patricia; Carratalá, Arturo; Núñez, Eduardo; Santas, Enrique; Bodí, Vicent; Chorro, Francisco J.; Miñana, Gema; Blasco, María L.; Sanchis, Juan; Núñez, Julio Elsevier (2015)Background Traditionally, procalcitonin (PCT) is considered a diagnostic marker of bacterial infections. However, slightly elevated levels of PCT have also been found in patients with heart failure. In this context, it ... -
Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure
Núñez, Julio; Rabinovich, Gabriel A.; Sandino, Justo; Mainar, Luis; Palau, Patricia; Santas, Enrique; Villanueva, María Pilar; Núñez, Eduardo; Bodí, Vicent; Chorro, Francisco J.; Miñana, Gema; Sanchis, Juan Public Library of Science (2015)Aims Galectin-3 (Gal-3) and carbohydrate antigen 125 (CA125) have emerged as robust prognostic biomarkers in heart failure. Experimental data have also suggested a potential molecular interaction between CA125 and Gal-3; ... -
Sacubitril/valsartan and short-term changes in the 6-minute walk test: A pilot study
Beltrán, Paola; Palau, Patricia; Domínguez Mafé, Eloy; Faraudo, Mercedes; Núñez, Eduardo Elsevier (2018-02)Background Impaired exercise capacity is the most disabling symptom in patients with heart failure with reduced ejection fraction (HFrEF). Despite sacubitril/valsartan showing reduced long-term morbidity and mortality ... -
Sex-differential effect of frailty on long-termmortality in elderly patients after an acute coronary syndrome
Núñez, Julio; Palau, Patricia; Sastre, Clara; D'Ascoli, Giulio; Ruiz, Vicente; Bonanad, Clara; Miñana, Gema; Núñez, Eduardo; Sanchis, Juan Elsevier (2019-12-31)Background The potential sex-differential effect of frailty in patients with acute coronary syndromes (ACS) has not been well-evaluated. We sought to examine the sex-differential association between frailty status on ... -
Short-term Changes in Hemoglobin and Changes in Functional Status, Quality of Life and Natriuretic Peptides After Initiation of Dapagliflozin in Heart Failure With Reduced Ejection Fraction
Lorenzo, Miguel; Miñana, Gema; Palau, Patricia; Amiguet, Martina; Seller, Julia; García Pinilla, José Manuel; Villar, Sandra; De la Espriella, Rafael; Núñez, Eduardo; Górriz, José Luis; Valle, Alfonso; Bodí, Vicent; Sanchis, Juan; Bayes-Genis, Antoni; Núñez, Julio; DAPA-VO2 Investigators Elsevier (2023-05)Background: We aimed to evaluate the effect of dapagliflozin on short-term changes in hemoglobin in patients with stable heart failure with reduced ejection fraction (HFrEF) and whether these changes mediated the effect ... -
Six-minute walk test in moderate to severe heart failure with preserved ejection fraction: Useful for functional capacity assessment?
Palau, Patricia; Domínguez Mafé, Eloy; Núñez, Eduardo; Sanchis, Juan; Santas, Enrique; Núñez, Julio Elsevier (2016-01-15)Despite improvements in medical treatment and prevention, heart failure (HF) remains a major cause of morbidity and mortality worldwide [1]. Currently, HF with preserved ejection fraction (HFpEF) has become the most prevalent ...