Listar por autoría "55b68a40-d9cf-4637-aa88-3340029b1d80"
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Análisis crítico de los estudios de neuroimagen en relación con el rendimiento cognitivo en pacientes con esclerosis múltiple
Cruz Gómez, Álvaro Javier; Belenguer Benavides, Antonio; González Rosa, Javier J.; Simón Gozalbo, Ana; Forn, Cristina Viguera (2011)El estudio y comprensión del deterioro cognitivo en los pacientes de esclerosis múltiple (EM) resulta esencial para entender esta enfermedad. El uso de las técnicas de neuroimagen puede aportar datos a la comprensión de ... -
Beyond “sex prediction”: estimating and interpreting multivariate sex differences and similarities in the brain
Sanchis-Segura, Carla; Aguirre, Naiara; Cruz Gómez, Álvaro Javier; Félix-Esbrí, Sonia; Forn, Cristina Elsevier ScienceDirect (2022-05-30)Previous studies have shown that machine-learning (ML) algorithms can “predict” sex based on brain anatomical/ functional features. The high classification accuracy achieved by ML algorithms is often interpreted as revealing ... -
Cambios estructurales y funcionales del hipocampo en pacientes con esclerosis múltiple y su relación con procesos de memoria
Cruz Gómez, Álvaro Javier; Belenguer Benavides, Antonio; Martínez Bronchal, Beatriz; Fittipaldi Márquez, María Sol; Forn, Cristina Viguera editores (2016-01)Introducción. Una de las alteraciones cognitivas más prevalentes en los pacientes con esclerosis múltiple son los proble- mas de codificación de la información (tanto verbal como visual), proceso relacionado con el ... -
Do Gender-Related Stereotypes Affect Spatial Performance? Exploring When, How and to Whom Using a Chronometric Two-Choice Mental Rotation Task
Sanchis-Segura, Carla; Aguirre, Naiara; Cruz Gómez, Álvaro Javier; Solozano Belenguer, Noemí; Forn, Cristina Frontiers Media (2018-07-24)It is a common belief that males have superior visuospatial abilities and that differences in this and other cognitive domains (e.g., math) contribute to the reduced interest and low representation of girls and women in ... -
Effects of different intracranial volume correction methods on univariate sex differences in grey matter volume and multivariate sex prediction
Sanchis-Segura, Carla; Ibáñez Gual, Maria Victoria; Aguirre, Naiara; Cruz Gómez, Álvaro Javier; Forn, Cristina Nature Research (2020)Sex differences in 116 local gray matter volumes (GMVOL) were assessed in 444 males and 444 females without correcting for total intracranial volume (TIV) or after adjusting the data with the scaling, proportions, ... -
Enhanced frontoparietal connectivity in multiple sclerosis patients and healthy controls in response to an intensive computerized training focused on working memory
Aguirre, Naiara; Cruz Gómez, Álvaro Javier; Félix Esbrí, Sonia; Miró-Padilla, Anna; Bueichekú, Elisenda; Avila, Cesar; Sanchis-Segura, Carla; Forn, Cristina; Broseta Torres, Ricardo Elsevier ScienceDirect (2021-04-24)Background: Working memory (WM) deficits are common in multiple sclerosis (MS) patients. Computerized cognitive training may enhance WM capabilities but its efficacy in MS patients has not been sufficiently explored. ... -
El entrenamiento en memoria de trabajo mejora la eficiencia cognitiva en pacientes de Esclerosis Múltiple
Aguirre, Naiara; Cruz Gómez, Álvaro Javier; Miró-Padilla, Anna; Bueichekú, Elisenda; Solozano Belenguer, Noemí; Broseta Torres, Ricardo; Avila, Cesar; Sanchis-Segura, Carla; Forn, Cristina Aten-D (2018)La Esclerosis Múltiple (EM) es una enfermedad en la que la memoria de trabajo (MT) se encuentra comúnmente afectada. Estudiar la eficacia de un programa de entrenamiento en MT en pacientes de EM. 29 pacientes de EM ... -
Exploring Neural Efficiency in Multiple Sclerosis Patients during the Symbol Digit Modalities Test: A Functional Magnetic Resonance Imaging Study
Fittipaldi Márquez, María Sol; Cruz Gómez, Álvaro Javier; Sanchis-Segura, Carla; Belenguer, A.; Avila, Cesar; Forn, Cristina Karger Publishers (2017)Background: Reduced information-processing speed (IPS) is a primary cognitive deficit of multiple sclerosis (MS) patients. The neural efficiency hypothesis describes an inverse relationship between cognitive performance ... -
Gray matter atrophy is associated with funcional connectivity reorganization during the Pasat Auditory Serial Addition Test (PASAT) execution in Multiple Sclerosis (MS)
Baltruschat, Sabina Anna; Ventura Campos, Mercedes; Cruz Gómez, Álvaro Javier; Belenguer Benavides, Antonio; Forn, Cristina Elsevier (2015-06)Background and purpose: We explored the relationship between gray matter atrophy and reorganization of functional connectivity in multiple sclerosis patients during execution of the Paced Auditory Serial Addition Test ... -
Hippocampal dysfunction is associated with memory impairment in multiple sclerosis: A volumetric and functional connectivity study
González Torre, Julio Alberto; Cruz Gómez, Álvaro Javier; Belenguer Benavides, Antonio; Sanchis-Segura, Carla; Avila, Cesar; Forn, Cristina SAGE Publications (2017)BACKGROUND: Previous studies have suggested a relationship between neuroanatomical and neurofunctional hippocampal alterations and episodic memory impairments in multiple sclerosis (MS) patients OBJECTIVE: We examined ... -
Increased regional gray matter atrophy and enhanced functional connectivy in male multiple sclerosis patients
Sanchis-Segura, Carla; Cruz Gómez, Álvaro Javier; Belenguer Benavides, Antonio; Fittipaldi Márquez, María Sol; Avila, Cesar; Forn, Cristina Elsevier (2016-09)Evidence suggests that sex/gender is an important factor for understanding multiple sclerosis (MS) and that some of its neuropathological consequences might manifest earlier in males. In the present study, we assessed gray ... -
Learning and Memory Impairments in Patients with Minimal Hepatic Encephalopathy are Associated with Structural and Functional Connectivity Alterations in Hippocampus
García-García, Raquel; Cruz Gómez, Álvaro Javier; Urios, Amparo; Mangas-Losada, Alba; Forn, Cristina; Escudero-García, Desamparados; Kosenko, Elena; Torregrosa, Isidro; Tosca, Joan; Giner-Durán, Remedios; Serra, Miguel Ángel; Avila, Cesar; Belloch, Vicente; Felipo, Vicente; Montoliu, Carmina Nature (2018)Patients with minimal hepatic encephalopathy (MHE) show mild cognitive impairment associated with alterations in attentional and executive networks. There are no studies evaluating the relationship between memory in MHE ... -
Multiple Sclerosis and Depression: Translation and Adaptation of the Spanish Version of the Chicago Multiscale Depression Inventory and the Study of Factors Associated with Depressive Symptoms
Sanchis-Segura, Carla; Cruz Gómez, Álvaro Javier; Félix Esbrí, Sónia; Sebastián Tirado, Alba; Arnett, Peter A; Forn, Cristina Oxford University Press (2022-12-08)Objective: Depressive disorder occurs in up to 50% of persons with Multiple Sclerosis (PwMS). Accurate assessment of depression in MS is essential in clinical settings because depressive symptomatology can affect the ... -
Reduced resting state connectivity and gray matter volume correlate with cognitive impairment in minimal hepatic encephalopathy
García-García, Raquel; Cruz Gómez, Álvaro Javier; Mangas-Losada, Alba; Urios, Amparo; Forn, Cristina; Escudero-García, Desamparados; Kosenko, Elena; Ordoño, Juan Fermín; Tosca, Joan; Giner-Durán, Remedios; Serra, Miguel Ángel; Avila, Cesar; Belloch, Vicente; Felipo, Vicente; Montoliu, Carmina Public Library of Science (2017)Background and aims Minimal hepatic encephalopathy (MHE) is associated with cognitive alterations and changes in connectivity. We assessed the relationship of the abnormalities of resting-state functional connectivity ... -
Regional Brain Atrophy and Functional Connectivity Changes Related to Fatigue in Multiple Sclerosis
Cruz Gómez, Álvaro Javier; Ventura Campos, Mercedes; Belenguer Benavides, Antonio; Avila, Cesar; Forn, Cristina Public Library of Science (2013)Fatigue is one of the most frequent symptoms in multiple sclerosis (MS), and recent studies have described a relationship between the sensorimotor cortex and its afferent and efferent pathways as a substrate of fatigue. ... -
Relación entre las alteraciones estructurales y el deterioro cognitivo en pacientes con Esclerosis Múltiple
Cruz Gómez, Álvaro Javier; Belenguer Benavides, Antonio; Ventura Campos, Mercedes; Forn, Cristina; Simón Gozalbo, Ana Universitat Jaume I (2011)Las causas del deterioro cognitivo en los pacientes de Esclerosis Múltiple (EM) son todavía desconocidas, así como la relación entre dicho deterioro y el daño cerebral observado con distintas técnicas de adquisición ... -
Repeated Working Memory Training Improves Task Performance and Neural Efficiency in Multiple Sclerosis Patients and Healthy Controls
Aguirre, Naiara; Cruz Gómez, Álvaro Javier; Miró-Padilla, Anna; Bueichekú, Elisenda; Broseta Torres, Ricardo; Avila, Cesar; Sanchis-Segura, Carla; Forn, Cristina Hindawi (2019)Background/Objective. To explore the efectiveness of a specifc working memory (WM) training program in MS patients and healthy controls (HC). Method. 29 MS patients and 29 matched HC were enrolled in the study. MS and HC ... -
Sex differences in gray matter volume: how many and how large are they really?
Sanchis-Segura, Carla; Ibáñez Gual, Maria Victoria; Adrián-Ventura, Jesús; Aguirre, Naiara; Cruz Gómez, Álvaro Javier; Avila, Cesar; Forn, Cristina BMC (2019-07-01)Background: Studies assessing volumetric sex differences have provided contradictory results. Total intracranial volume (TIV) is a major confounding factor when estimating local volumes of interest (VOIs). We investigated ... -
Subcortical grey matter structures in multiple sclerosis: what is their role in cognition?
Cruz Gómez, Álvaro Javier; Aguirre, Naiara; Sanchis-Segura, Carla; Avila, Cesar; Forn, Cristina Lippincott, Williams & Wilkins (2018)The present study aimed to investigate altered grey matter (GM) and functional connectivity (FC) in deep subcortical areas, like the thalamus and basal ganglia, and their relationship with cognitive impairment in multiple ... -
Task-load manipulation in the Symbol Digit Modalities Test: An alternative measure of information processing speed
Forn, Cristina; Ripollés, P.; Cruz Gómez, Álvaro Javier; Belenguer Benavides, Antonio; González Torre, Julio Alberto; Avila, Cesar Elsevier (2013-07)Objective To evaluate the utility of an oral fMRI-adapted version of the Symbol Digit Modalities Test (SDMT) to assess information processing speed (IPS) using three different interstimulus intervals (ISI). Methods Nineteen ...