Browsing by Author "52748e57-41d6-4f2c-923e-564bc4e41fcc"
Now showing items 1-17 of 17
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Association between Microbiome-Related Human Genetic Variants and Fasting Plasma Glucose in a High-Cardiovascular-Risk Mediterranean Population
Asensio, Eva Maria; Ortega-Azorín, Carolina; Barragán-Arnal, Rocío; Alvarez-Sala, Andrea; Sorlí, José V; Pascual, Eva C.; Fernández-Carrión, Rebeca; Villamil, Laura V.; Corella, Dolores; Coltell, Oscar MDPI (2022)Background and Objectives: The gut microbiota has been increasingly recognized as a relevant factor associated with metabolic diseases. However, directly measuring the microbiota composition is a limiting factor for ... -
Associations between the New DNA-Methylation-Based Telomere Length Estimator, the Mediterranean Diet and Genetics in a Spanish Population at High Cardiovascular Risk
Coltell, Oscar; Asensio, Eva Maria; Sorlí, José V; Ortega-Azorín, Carolina; Fernandez Carrion, Rebeca; Pascual, Eva C.; Barragán-Arnal, Rocío; González, José I.; Estruch, Ramon; Alzate, Juan F.; Pérez-Fidalgo, J. Alejandro; Portolés, Olga; Ordovas, Jose M.; Corella, Dolores MDPI (2023-11)Biological aging is a relevant risk factor for chronic diseases, and several indicators for measuring this factor have been proposed, with telomere length (TL) among the most studied. Oxidative stress may regulate telomere ... -
Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects
Barragán-Arnal, Rocío; Coltell, Oscar; Portolés, Olga; Asensio, Eva Maria; Sorlí, José V; CAROLINA, ORTEGA-AZORÍN; González, José I.; Sáiz, Carmen; Fernández-Carrión, Rebeca; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2018)There is growing interest in relating taste perception to diet and healthy aging. However, there is still limited information on the influence of age, sex and genetics on taste acuity as well as on the relationship between ... -
Chronological age interacts with the circadian melatonin receptor 1b gene variation, determining fasting glucose concentrations in mediterranean populations. Additional analyses on type-2 diabetes risk
Sorlí, José V; Barragán-Arnal, Rocío; Coltell, Oscar; Portolés, Olga; Pascual, Eva C.; CAROLINA, ORTEGA-AZORÍN; González, José I.; Estruch, Ramon; Saiz, Carmen; Pérez-Fidalgo, J. Alejandro; Ordovas, Jose; Corella, Dolores MDPI (2020-11-01)Gene-age interactions have not been systematically investigated on metabolic phenotypes and this modulation will be key for a better understanding of the temporal regulation in nutrigenomics. Taking into account that ... -
Circulating adiponectin and Its association with metabolic traits and Type 2 Diabetes: gene-diet interactions focusing on selected gene variants and at the genome-wide level in high-cardiovascular risk mediterranean subjects
Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Portolés, Olga; Asensio, Eva Maria; Saiz, Carmen; Barragán-Arnal, Rocío; Estruch, Ramon; Corella, Dolores MDPI (2021-02-07)Adiponectin is gaining renewed interest since, in addition to its possible protective role against insulin resistance and arteriosclerosis, recent studies suggest other additional favorable effects. However, the influence ... -
Crosstalk between smoking and the genome in older subjects with metabolic syndrome through genomics, epigenomics and transcriptomics
Coltell, Oscar; Asensio, Eva Maria; CAROLINA, ORTEGA-AZORÍN; Barragán-Arnal, Rocío; Sáiz, Carmen; Portolés, Olga; Sorlí, José V; Corella, Dolores European Molecular Biology Organization (EMBO) (2019-09-11)Tobacco smoking (Figure 1) is a major cause of cardiovascular diseases (CVD), and appears to have a multiplicative interaction with the other major CVD risk factors (lipids, hypertension, diabetes and others present in the ... -
Effect of Physical Activity, Smoking, and Sleep on Telomere Length: A Systematic Review of Observational and Intervention Studies
Barragán-Arnal, Rocío; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Asensio, Eva Maria; Coltell, Oscar; St-Onge, Marie-Pierre; Portolés, Olga; Corella, Dolores MDPI (2021-12-24)Aging is a risk factor for several pathologies, restricting one’s health span, and promoting chronic diseases (e.g., cardiovascular and neurodegenerative diseases), as well as cancer. Telomeres are regions of repetitive ... -
Genome-wide association analyses of weight loss in a randomized controlled trial of lifestyle intervention, and combined transcriptome-wide associations in a Mediterranean population
Corella, Dolores; Asensio, Eva Maria; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Fernández-Carrión, Rebeca; Barragán-Arnal, Rocío; González, José I.; Coltell, Oscar European Molecular Biology Organization (EMBO) (2019-09-11)Although large-scale genome-wide association studies (GWAS) for obesity traits have identified more than 400 associated loci from observational studies (Figure 1), we highlight the fact that currently the number of GWAS ... -
Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population
Coltell, Oscar; Asensio, Eva Maria; Sorlí, José V; Barragán-Arnal, Rocío; Fernández-Carrión, Rebeca; Portolés, Olga; CAROLINA, ORTEGA-AZORÍN; Martínez-LaCruz, Raúl; González, José I.; Zanón-Moreno, Vicente; Gimenez Alba, Ignacio Manuel; Fitó, Montserrat; Ros, Emilio; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2019)Although, for decades, increased serum bilirubin concentrations were considered a threatening sign of underlying liver disease and had been associated with neonatal jaundice, data from recent years show that bilirubin is ... -
Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome
Coltell, Oscar; Sorlí, José V; Asensio, Eva Maria; Barragán-Arnal, Rocío; González, José I.; Gimenez Alba, Ignacio Manuel; Zanón-Moreno, Vicente; Estruch, Ramon; Ramírez-Sabio, Judith B.; Pascual, Eva C.; CAROLINA, ORTEGA-AZORÍN; Ordovas, Jose; Corella, Dolores MDPI (2020)Many early studies presented beneficial effects of polyunsaturated fatty acids (PUFA) on cardiovascular risk factors and disease. However, results from recent meta-analyses indicate that this effect would be very low or ... -
Influence of Demographic and Lifestyle Variables on Plasma Magnesium Concentrations and Their Associations with Cardiovascular Risk Factors in a Mediterranean Population
Barragán-Arnal, Rocío; Llopis, Juan; Portolés, Olga; Sorlí, José V; Coltell, Oscar; Rivas-García, Lorenzo; Asensio, Eva Maria; CAROLINA, ORTEGA-AZORÍN; Corella, Dolores; Sánchez-González, Cristina MDPI (2020)Several studies have shown that a low magnesium (Mg) intake in the diet is associated with greater cardiovascular risk and greater risk of diabetes. However, the results are not consistent in all populations. To minimize ... -
Influence of DNA-Polymorphisms in Selected Circadian Clock Genes on Clock Gene Expression in Subjects from the General Population and Their Association with Sleep Duration
Barragán-Arnal, Rocío; Sorlí, José V; Coltell, Oscar; Gonzalez-Monje, Inmaculada; Fernández-Carrión, Rebeca; Villamil, Laura V.; Portolés, Olga; Corella, Dolores; Ortega-Azorín, Carolina; Asensio, Eva Maria MDPI (2022)Background and Objectives: Circadian rhythms have an important implication in numerous physiological and metabolic processes, including the sleep/wake cycle. Inter-individual differences in factors associated with circadian ... -
Metabolites, genomics, epigenomics, exposomics and health: Focus on serum bilirubin concentrations in subjects with metabolic syndrome from a Mediterranean population
Coltell, Oscar; Asensio, Eva Maria; Barragán-Arnal, Rocío; Sorlí, José V; Corella, Dolores Gordon Research Conferences (2019-02-03)Although metabolomics aims at the measurement of small molecules (metabolites) in a biological sample, this knowledge requires additional information on the related genetic variants, epigenetic regulators and environmental ... -
MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population
Barragán-Arnal, Rocío; Coltell, Oscar; Asensio, Eva Maria; Francés, Francesc; Sorlí, José V; Estruch, Ramon; Salas Huetos, Albert; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2016)Recently, microRNAs (miRNA) have been proposed as regulators in the different processes involved in alcohol intake, and differences have been found in the miRNA expression profile in alcoholics. However, no study has ... -
Nutrigenética, nutrigenómica y dieta mediterránea: una nueva visión para la gastronomía
Corella, Dolores; Barragán-Arnal, Rocío; Ordovás Muñoz, José M.; Coltell, Oscar Arán Ediciones (2018)Tanto la nutrigenética como la nutrigenómica son disciplinas dentro de la denominada genómica nutricional, que, en sentido amplio, proporciona el marco de integración de las distintas ómicas con las ciencias de la ... -
Single and Combined Associations of Plasma and Urine Essential Trace Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a Mediterranean Population
Barragán-Arnal, Rocío; Sánchez González, Cristina; Aranda, Pilar; Sorlí, José V; Asensio, Eva Maria; Portolés, Olga; Ortega-Azorín, Carolina; Villamil, Laura V.; Coltell, Oscar; Llopis, Juan; Rivas García, Lorenzo; Corella, Dolores (2022-10)Trace elements are micronutrients that are required in very small quantities through diet but are crucial for the prevention of acute and chronic diseases. Despite the fact that initial studies demonstrated inverse ... -
Sweet Taste Preference: Relationships with Other Tastes, Liking for Sugary Foods and Exploratory Genome-Wide Association Analysis in Subjects with Metabolic Syndrome
Fernández-Carrión, Rebeca; Sorlí, José V; Coltell, Oscar; Pascual, Eva C.; Ortega-Azorín, Carolina; Barragán-Arnal, Rocío; Gimenez Alba, Ignacio Manuel; Alvarez-Sala, Andrea; Fitó, Montserrat; Ordovas, Jose M.; Corella, Dolores MDPI (2022-01)Taste perception and its association with nutrition and related diseases (type 2 diabetes, obesity, metabolic syndrome, cardiovascular, etc.) are emerging fields of biomedicine. There is currently great interest in ...