Listar por autoría "4ad0862e-3e0c-414e-9566-fb7d0dbb29e0"
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Alcohol Binge Drinking and Anxiety‐Like Behavior in Socialized Versus Isolated C57BL/6J Mice
Evans, Ophelia; Rodríguez Borillo, Olga; Font Hurtado, Laura; Currie, Paul J.; Pastor Medall, Raúl Wiley (2020-01)Background: Binge alcohol drinking has been characterized as a key feature of alcoholism. The drinking‐in‐the‐dark (DID) preclinical model, a procedure that promotes high levels of ethanol (EtOH) intake in short periods ... -
Dopamine/adenosine interactions related to locomotion and tremor in animal models: Possible relevance to parkinsonism
Salamone, John; Ishiwari, K.; Betz, Adrienne J.; Farrar, Andrew M.; Mingote, Susana; Font Hurtado, Laura; Hockemeyer, J.; Müller, Christa E.; Correa, Merce Elsevier (2008)Adenosine A<sub>2A</sub> antagonists can exert antiparkinsonian effects in animal models. Recent experiments studied the ability of MSX-3 (an adenosine A<sub>2A</sub> antagonist) to reverse the locomotor suppression and ... -
Effects of naltrexone on alcohol, sucrose, and saccharin binge-like drinking in C57BL/6J mice: a study with a multiple bottle choice procedure
Morales, Ileana; Rodríguez Borillo, Olga; Font Hurtado, Laura; Pastor Medall, Raúl Lippincott, Williams & Wilkins (2020-04)Chronic alcohol (ethyl alcohol, EtOH) binging has been associated with long-term neural adaptations that lead to the development of addiction. Many of the neurobiological features of EtOH abuse are shared with other forms ... -
Effects of the adenosine A2A antagonist KW 6002 (istradefylline) on pimozide-induced oral tremor and striatal c-Fos expression: comparisons with the muscarinic antagonist tropicamide
Betz, Adrienne J.; Vontell, Regina; Valenta, J.; Worden, Lila T.; Sink, Kelly S.; Font Hurtado, Laura; Correa, Merce; Sager, Thomas Nikolaj; Salamone, John Elsevier (2009-09)Typical antipsychotic drugs, including haloperidol and pimozide, have been shown to produce parkinsonian motor effects such as akinesia and tremor. Furthermore, there is an antagonistic interaction between adenosine A2A ... -
Forebrain circuitry involved in effort-related choice: Injections of the GABAA agonist muscimol into ventral pallidum alter response allocation in food-seeking behavior
Farrar, Andrew M.; Font Hurtado, Laura; Pereira, Mariana; Mingote, Susana; Bunce, Jamie G.; Chrobak, James; Salamone, John Elsevier (2008-03)Organisms often make effort-related choices based upon assessments of motivational value and work requirements. Nucleus accumbens dopamine is a critical component of the brain circuitry regulating work output in ... -
Intra-accumbens injections of the adenosine A(2A) agonist CGS 21680 affect effort-related choice behavior in rats
Stopper, Colin M.; Worden, Lila T.; Mingote, Susana; Port, Russell G.; Salamone, John; Font Hurtado, Laura; Pereira, Mariana; Farrar, Andrew M. Springer Verlag (2008)Rationale: Nucleus accumbens dopamine (DA) participates in the modulation of instrumental behavior, including aspects of behavioral activation and effort-related choice behavior. Rats with impaired accumbens DA transmission ... -
Involvement of brain catalase activity in the acquisition of ethanol-induced conditioned place preference
Font Hurtado, Laura; MIQUEL, MARTA; González Aragón, Carlos Manuel Elsevier (2008)It has been suggested that some of the behavioral effects produced by ethanol are mediated by its first metabolite, acetaldehyde. The present research addressed the hypothesis that catalase-dependent metabolism of ethanol ... -
Involvement of the beta-endorphin neurons of the hypothalamic arcuate nucleus in ethanol-induced place preference conditioning in mice
Pastor Medall, Raúl; Font Hurtado, Laura; MIQUEL, MARTA; Phillips, Tamara J.; González Aragón, Carlos Manuel Wiley (2011-10-20)Background: Increasing evidence indicates that mu- and delta-opioid receptors are decisively involved in the retrieval of memories underlying conditioned effects of ethanol. The precise mechanism by which these receptors ... -
Involvement of the endogenous opioid system in the psychopharmacological actions of ethanol: the role of acetaldehyde
Font Hurtado, Laura; Luján Pérez, Miguel Ángel; Pastor Medall, Raúl Frontiers Media (2013)Significant evidence implicates the endogenous opioid system (EOS) (opioid peptides and receptors) in the mechanisms underlying the psychopharmacological effects of ethanol. Ethanol modulates opioidergic signaling and ... -
Modulation of ethanol-induced conditioned place preference in mice by 3-amino-1,2,4-triazole and D-penicillamine depends on ethanol dose and number of conditioning trials
Ledesma Llorente, Juan Carlos; Font Hurtado, Laura; Baliño, Pablo; González Aragón, Carlos Manuel Springer (2013)Previous studies have shown that both 3-amino-1,2,4-triazole (AT), which inhibits metabolism of ethanol (EtOH) to acetaldehyde by inhibiting catalase, and D-penicillamine (D-P), an acetaldehyde-sequestering agent, modulate ... -
Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in mice
Font Hurtado, Laura; Houck, Christa A.; Cunningham, Christopher L. Springer Verlag (2017)Rationale Previous studies found that naloxone (NLX) facilitated choice extinction of ethanol conditioned place preference (CPP) using long (60 min) test sessions, but there is little information on the variables ... -
Neural correlates of cocaine-induced conditioned place preference in the posterior cerebellar cortex
Rodríguez Borillo, Olga; Roselló-Jiménez, Lorena; Guarque-Chabrera, Julian; Palau-Batet, María; Gil-Miravet, Isis; Pastor Medall, Raúl; MIQUEL, MARTA; Font Hurtado, Laura Frontiers Media (2023)Introduction: Addictive drugs are potent neuropharmacological agents capable of inducing long-lasting changes in learning and memory neurocircuitry. With repeated use, contexts and cues associated with consumption can ... -
Nucleus Accumbens Adenosine A2A Receptors Regulate Exertion of Effort by Acting on the Ventral Striatopallidal Pathway
Font Hurtado, Laura; Mingote, Susana; Farrar, Andrew M.; Vontell, Regina; Worden, Lila T.; Stopper, Colin M.; Port, Russell G.; Sink, Kelly S.; Bunce, Jamie G.; Chrobak, James; Salamone, John Society for Neuroscience (2008)Goal-directed actions are sensitive to work-related response costs, and dopamine in nucleus accumbens is thought to modulate the exertion of effort in motivated behavior. Dopamine-rich striatal areas such as nucleus ... -
Post-retrieval propranolol treatment does not modulate reconsolidation or extinction of ethanol-induced conditioned place preference
Font Hurtado, Laura; Cunningham, Christopher L. Elsevier (2012)The reconsolidation hypothesis posits that established emotional memories, when reactivated, become labile and susceptible to disruption. Post-retrieval injection of propranolol (PRO), a nonspecific ß-adrenergic receptor ... -
The H2O2 scavenger ebselen decreases ethanol-induced locomotor stimulation in mice
Ledesma Llorente, Juan Carlos; González Aragón, Carlos Manuel; Font Hurtado, Laura Elsevier (2012)Background In the brain, the enzyme catalase by reacting with H2O2 forms Compound I (catalase–H2O2 system), which is the main system of central ethanol metabolism to acetaldehyde. Previous research has demonstrated that ...