Listar por autoría "43c87277-948e-44b2-bb16-74bbcbf25a55"
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Avoidance and contextual learning induced by a kairomone, a pheromone and a common odorant in female CD1 mice
Fortes Marco, Lluís; Lanuza, Enrique; Martinez-Garcia, Fernando; Agustín-Pavón, Carmen Frontiers Media (2015)Chemosignals mediate both intra- and inter-specific communication in most mammals. Pheromones elicit stereotyped reactions in conspecifics, whereas kairomones provoke a reaction in an allospecific animal. For instance, ... -
Becoming a mother shifts the activity of the social and motivation brain networks in mice
Navarro-Moreno, Cinta; Barneo-Muñoz, Manuela; Ibáñez Gual, Maria Victoria; Lanuza, Enrique; Agustín-Pavón, Carmen; Sánchez-Catalán, María José; Martinez-Garcia, Fernando Elsevier (2022-06-03)During pregnancy hormones increase motivated pup-directed behaviors. We here analyze hormone-induced changes in brain activity, by comparing cFos-immunoreactivity in the sociosexual (SBN) and motivation brain networks ... -
Deimmunization for gene therapy: host matching of synthetic zinc finger constructs enables long-term mutant Huntingtin repression in mice
Agustín-Pavón, Carmen; Mielcarek, Michal; Garriga-Canut, Mireia; Isalan, Mark BioMed Central (2016)Background: Synthetic zinc finger (ZF) proteins can be targeted to desired DNA sequences and are useful tools for gene therapy. We recently developed a ZF transcription repressor (ZF-KOX1) able to bind to expanded DNA ... -
Distribution of oxytocin and co-localization with arginine vasopressin in the brain of mice
Otero García, Marcos; Agustín-Pavón, Carmen; Lanuza, Enrique; Martinez-Garcia, Fernando Springer Verlag (2015-09-20)Oxytocin (OT) and vasopressin (AVP) play a major role in social behaviours. Mice have become the species of choice for neurobiology of social behaviour due to identification of mouse pheromones and the advantage of genetically ... -
Explorant teràpies biotecnològiques contra les malalties neurodegeneratives
Agustín-Pavón, Carmen Agrupació Borrianenca de Cultura (2016)Les malalties neurodegeneratives es troben entre les causes més importants de mort i discapacitat als països occidentals. Les teràpies clàssiques, com ara les farmacològiques, són purament simptomàtiques, és a dir, tracten ... -
Extending the socio-sexual brain: arginine-vasopressin immunoreactive circuits in the telencephalon of mice
Otero García, Marcos; Martín Sánchez, Ana; Fortes Marco, Lluís; Martínez-Ricós, Joana; Agustín-Pavón, Carmen; Lanuza, Enrique; Martinez-Garcia, Fernando Springer Berlin Heidelberg (2014-05)Quantitative analysis of the immunoreactivity for arginine-vasopressin (AVP-ir) in the telencephalon of male (intact and castrated) and female CD1 mice allows us to precisely locate two sexually dimorphic (more abundant ... -
Focal lesions within the ventral striato-pallidum abolish attraction for male chemosignals in female mice
Agustín-Pavón, Carmen; Martinez-Garcia, Fernando; Lanuza, Enrique Elsevier (2014-02)In rodents, socio-sexual behaviour is largely mediated by chemosensory cues, some of which are rewarding stimuli. Female mice display an innate attraction towards male chemosignals, dependent on the vomeronasal system. ... -
Focal Lesions within the ventral striato-pallidum abolish attraction for male chemosignals in female mice
Agustín-Pavón, Carmen; Martinez-Garcia, Fernando; Lanuza, Enrique Elsevier (2014-02)In rodents, socio-sexual behaviour is largely mediated by chemosensory cues, some of which are rewarding stimuli. Female mice display an innate attraction towards male chemosignals, dependent on the vomeronasal system. ... -
Glutamate and Opioid Antagonists Modulate Dopamine Levels Evoked by Innately Attractive Male Chemosignals in the Nucleus Accumbens of Female Rats
Sánchez-Catalán, María José; Orrico, Alejandro; Hipólito, Lucía; Zornoza, Teodoro; Polache, Ana; Lanuza, Enrique; Martinez-Garcia, Fernando; Granero, Luis; Agustín-Pavón, Carmen Frontiers Media (2017-02-23)Sexual chemosignals detected by vomeronasal and olfactory systems mediate intersexual attraction in rodents, and act as a natural reinforcer to them. The mesolimbic pathway processes natural rewards, and the nucleus ... -
Inhibition of the medial amygdala disrupts escalated aggression in lactating female mice after repeated exposure to male intruders
Abellán-Álvaro, María; Martinez-Garcia, Fernando; Agustín-Pavón, Carmen Nature Research (2022-09-16)Virgin female laboratory mice readily express pup care when co-housed with dams and pups. However, pup-sensitized virgins fail to express intruder-directed aggression on a single session of testing. To study whether repeated ... -
Intraspecific Communication Through Chemical Signals in Female Mice: Reinforcing Properties of Involatile Male Sexual Pheromones
Martínez-Ricós, Joana; Agustín-Pavón, Carmen; Lanuza, Enrique; Martinez-Garcia, Fernando Oxford University Press (2007)In rodents, social and reproductive behaviors critically depend on chemical signals, including sexual pheromones that have been suggested (but not demonstrated) to be rewarding. In this work, we analyze this issue by ... -
Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system
Martínez-Rodríguez, Elena; Martín Sánchez, Ana; Coviello, Simona; Foiani, Cristina; Kul, Emre; Martinez-Garcia, Fernando; Nacher, Juan; Lanuza, Enrique; Santos, Mónica; Agustín-Pavón, Carmen Springer (2019-05)The protein doublecortin is mainly expressed in migrating neuroblasts and immature neurons. The X-linked gene MECP2, associated to several neurodevelopmental disorders such as Rett syndrome, encodes the protein methyl-CpG-binding ... -
Male-specific features are reduced in Mecp2-null mice: analyses of vasopressinergic innervation, pheromone production and social behaviour
Martínez-Rodríguez, Elena; Martín Sánchez, Ana; Kul, Emre; Bose, Aparajita; Martínez-Martínez, Francisco José; Stork, Oliver; Martinez-Garcia, Fernando; Lanuza, Enrique; Santos, Mónica; Agustín-Pavón, Carmen Springer (2020-08-04)Deficits in arginine vasopressin (AVP) and oxytocin (OT), two neuropeptides closely implicated in the modulation of social behaviours, have been reported in some early developmental disorders and autism spectrum disorders. ... -
Maternal Motivation: Exploring the Roles of Prolactin and Pup Stimuli
Salais López, Hugo; Abellán-Álvaro, María; Bellés, María; Lanuza, Enrique; Agustín-Pavón, Carmen; Martinez-Garcia, Fernando Karger Publishers (2020-07-09)Motherhood entails increased motivation for pups, which become strong reinforcers and guide maternal behaviours. This depends on steroids and lactogens acting on the brain of females during pregnancy and postpartum. Since ... -
Motherhood-induced gene expression in the mouse medial amygdala: Changes induced by pregnancy and lactation but not by pup stimuli
Abellán-Álvaro, María; Ayala, Guillermo; Barneo-Muñoz, Manuela; Martinez-Garcia, Fernando; Agustín-Pavón, Carmen; Lanuza, Enrique Federation of American Society of Experimental Biology (2021)During lactation, adult female mice display aggressive responses toward male intrud-ers, triggered by male- derived chemosensory signals. This aggressive behavior is not shown by pup- sensitized virgin females sharing ... -
Pregnancy Changes the Response of the Vomeronasal and Olfactory Systems to Pups in Mice
Navarro-Moreno, Cinta; Sánchez-Catalán, María José; Barneo-Muñoz, Manuela; Goterris-Cerisuelo, Rafael; Bellés Esteller, María; Lanuza, Enrique; Agustín-Pavón, Carmen; Martinez-Garcia, Fernando Frontiers Media (2020-12-18)Motherhood entails changes in behavior with increased motivation for pups, induced in part by pregnancy hormones acting upon the brain. This work explores whether this alters sensory processing of pup-derived chemosignals. ... -
Refining the dual olfactory hypothesis: Pheromone reward and odour experience
Martinez-Garcia, Fernando; Martínez-Ricós, Joana; Agustín-Pavón, Carmen; Martínez-Hernández, José; Novejarque, Amparo; Lanuza, Enrique Elsevier (2009-06)In rodents, sexual advertisement and gender recognition are mostly (if not exclusively) mediated by chemosignals. Specifically, there is ample evidence indicating that female mice are ‘innately’ attracted by male sexual ... -
Role of nitric oxide in pheromone-mediated intraspecific communication in mice
Agustín-Pavón, Carmen; Martínez-Ricós, Joana; Martinez-Garcia, Fernando; Lanuza, Enrique Elsevier (2009-12)Nitric oxide is known to take part in the control of sexual and agonistic behaviours. This is usually attributed to its role in neural transmission in the hypothalamus and other structures of the limbic system. However, ... -
Role of the vomeronasal system in intersexual attraction in female mice
Martínez-Ricós, Joana; Agustín-Pavón, Carmen; Lanuza, Enrique; Martinez-Garcia, Fernando Elsevier (2008-05)Although it is generally accepted that rodents' sociosexual behavior relies mainly on chemosignals, the specific roles played by the vomeronasal and olfactory systems in detecting these signals are presently unclear. This ... -
Sexual pheromones and the evolution of the reward system of the brain: The chemosensory function of the amygdala
Lanuza, Enrique; Novejarque, Amparo; Martínez-Ricós, Joana; Martínez-Hernández, José; Agustín-Pavón, Carmen; Martinez-Garcia, Fernando Elsevier (2008-03)The amygdala of all tetrapod vertebrates receives direct projections from the main and accessory olfactory bulbs, and the strong similarities in the organization of these projections suggest that they have undergone a very ...