Listar por autoría "1e6cd105-0dc3-4ce0-a882-266f746924c7"
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A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics
Corella, Dolores; Coltell, Oscar; Portolés, Olga; Sotos-Prieto, Mercedes; Fernández-Carrión, Rebeca; Ramírez-Sabio, Judith B.; Zanón-Moreno, Vicente; Mattei, Josiemer; Sorlí, José V; Ordovás Muñoz, José M. MDPI (2019)Precision nutrition aims to make dietary recommendations of a more personalized nature possible, to optimize the prevention or delay of a disease and to improve health. Therefore, the characteristics (including sex) of ... -
A High Dietary Glycemic Index Increases Total Mortality in a Mediterranean Population at High Cardiovascular Risk
Castro-Quezada, Itandehui; Sánchez-Villegas, Almudena; Estruch, Ramon; Salas-Salvadó, Jordi; Corella, Dolores; Schoreder, Helmut; Álvarez-Pérez, Jacqueline; Ruiz-López, María Dolores; Artacho, Reyes; Ros, Emilio; Bulló, Mònica; Covas Planells, María Isabel; Ruiz-Gutiérrez, Valentina; Ruiz-Canela, Miguel; Buil-Cosiales, Pilar; Gómez-Gracia, Enrique; Lapetra, José; Pintó, Xavier; Arós, Fernando; Fiol Ramis, Miquel; Lamuela Raventós, Rosa María; Martínez González, Miguel Ángel; Serra-Majem, Lluis; PREDIMED Investigators Public Library of Science (2014)Objective: Different types of carbohydrates have diverse glycemic response, thus glycemic index (GI) and glycemic load (GL) are used to assess this variation. The impact of dietary GI and GL in all-cause mortality is ... -
Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect
Corella, Dolores; Coltell, Oscar; Macian, Fernando; Ordovás Muñoz, José M. Annual Reviews (2018)Increasingly, studies showing the protective effects of the Mediterranean diet (MedDiet) on different diseases (cardiovascular, diabetes, some cancers, and even total mortality and aging indicators) are being published. ... -
Amino acid change in the carbohydrate response element binding protein is associated with lower triglycerides and myocardial infarction incidence depending on level of adherence to the Mediterranean diet in the PREDIMED trial
CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Estruch, Ramon; Asensio, Eva Maria; Coltell, Oscar; González, José I.; Martínez González, Miguel Ángel; Ros, Emilio; Salas-Salvadó, Jordi; Fitó, Montserrat; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Ruiz-Gutiérrez, Valentina; Gómez Gracia, Enrique; Fiol Ramis, Miquel; Flores, Gemma; Pintó, Xavier; Sáiz, Carmen; Ordovás Muñoz, José M.; Corella, Dolores American Heart Association (2014-02)Background: A variant (rs3812316, C771G, Gln241His) in the MLXIPL (Max-like protein X interacting protein-like) gene encoding the carbohydrate response element binding protein has been associated with lower triglycerides. ... -
APOA2, Dietary Fat, and Body Mass Index: Replication of a Gene-Diet Interaction in 3 Independent Populations
Corella, Dolores; Peloso, Gina; Arnett, Donna K.; Demissie, Serkalem; Cupples, Adrienne; Tucker, Katherine; Lai, Chao-Qiang; Parnell, Laurence D.; Coltell, Oscar; Lee, Yu-Chi; Ordovás Muñoz, José M. American Medical Association (2009-11)For the first time to our knowledge, a gene-diet interaction influencing BMI and obesity has been strongly and consistently replicated in 3 independent populations. -
Association between dietary fibre intake and fruit, vegetable or whole-grain consumption and the risk of CVD: results from the PREvención con DIeta MEDiterránea (PREDIMED) trial
Buil-Cosiales, Pilar; Toledo, Estefanía; Salas-Salvadó, Jordi; Zazpe, Itziar; Farràs, Marta; Basterra-Gortari, Francisco Javier; Díez Espino, Javier; Estruch, Ramon; Corella, Dolores; Ros, Emilio; Marti, Amelia; Gómez Gracia, Enrique; Ortega-Calvo, Manuel; Arós, Fernando; Moñino, Manuel; Serra-Majem, Lluis; Pintó, Xavier; Lamuela Raventós, Rosa María; Babio, Nancy; González, José I.; Fitó, Montserrat; Martínez González, Miguel Ángel Nutrition Society (2016)Prospective studies assessing the association between fibre intake or fibre-rich food consumption and the risk of CVD have often been limited by baseline assessment of diet. Thus far, no study has used yearly repeated ... -
Association between Microbiome-Related Human Genetic Variants and Fasting Plasma Glucose in a High-Cardiovascular-Risk Mediterranean Population
Asensio, Eva Maria; Ortega-Azorín, Carolina; Barragán-Arnal, Rocío; Alvarez-Sala, Andrea; Sorlí, José V; Pascual, Eva C.; Fernández-Carrión, Rebeca; Villamil, Laura V.; Corella, Dolores; Coltell, Oscar MDPI (2022)Background and Objectives: The gut microbiota has been increasingly recognized as a relevant factor associated with metabolic diseases. However, directly measuring the microbiota composition is a limiting factor for ... -
Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction
Corella, Dolores; Tai, E-Shyong; Sorlí, José V; Chew, Suok Kai; Coltell, Oscar; Sotos Prieto, Mercedes; García Ríos, Antonio; Estruch, Ramon; Ordovás Muñoz, José M. Nature Publishing Group (2011-05)Objective: The APOA2 gene has been associated with obesity and insulin resistance (IR) in animal and human studies with controversial results. We have reported an APOA2–saturated fat interaction determining body mass index ... -
Association of the LCT-13910C>T polymorphism with obesity and its modulation by dairy products in a Mediterranean population
Corella, Dolores; Arregui, María; Coltell, Oscar; Portolés, Olga; Guillem Sáiz, Patricia; Carrasco, Paula; Sorlí, José V; CAROLINA, ORTEGA-AZORÍN; González, José I.; Ordovás Muñoz, José M. Nature Publishing Group (2011-08)The -13910C>T polymorphism (rs4988235) upstream from the lactase (LCT) gene, strongly associated with lactase persistence (LP) in Europeans, is emerging as a new candidate for obesity. We aimed to analyze the association ... -
Associations between the New DNA-Methylation-Based Telomere Length Estimator, the Mediterranean Diet and Genetics in a Spanish Population at High Cardiovascular Risk
Coltell, Oscar; Asensio, Eva Maria; Sorlí, José V; Ortega-Azorín, Carolina; Fernandez Carrion, Rebeca; Pascual, Eva C.; Barragán-Arnal, Rocío; González, José I.; Estruch, Ramon; Alzate, Juan F.; Pérez-Fidalgo, J. Alejandro; Portolés, Olga; Ordovas, Jose M.; Corella, Dolores MDPI (2023-11)Biological aging is a relevant risk factor for chronic diseases, and several indicators for measuring this factor have been proposed, with telomere length (TL) among the most studied. Oxidative stress may regulate telomere ... -
Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulate by diet, being higher when adherence to the Mediterranean diet pattern is low
Coltell, Oscar; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Gómez Gracia, Enrique; Fiol Ramis, Miquel; Sáez Tormo, Guillermo; Pintó, Xavier; Muñoz, Miguel Ángel; Ordovás Muñoz, José M.; Estruch, Ramon; Corella, Dolores; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Asensio, Eva Maria; Covas Planells, María Isabel; Ros, Emilio BioMed Central (2012-11)Background: Although the Fat Mass and Obesity (FTO) and Melanocortin-4 Receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is ... -
Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization
Smith, C.E.; Coltell, Oscar; Sorlí, José V; Estruch, Ramon; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Fitó, Montserrat; Arós, Fernando; Dashti, Hassan S.; Lai, Chao-Qiang; Miró, Leticia; Serra-Majem, Lluis; Gómez Gracia, Enrique; Fiol Ramis, Miquel; Ros, Emilio; Aslibekyan, Stella; Hidalgo, Bertha; Neuhouser, Marian L.; Di, Chongzhi; Tucker, Katherine; Arnett, Donna K.; Ordovás Muñoz, José M.; Corella, Dolores Nature Publishing Group (2016)Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and clarify diet-disease relationships through ... -
Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects
Barragán-Arnal, Rocío; Coltell, Oscar; Portolés, Olga; Asensio, Eva Maria; Sorlí, José V; CAROLINA, ORTEGA-AZORÍN; González, José I.; Sáiz, Carmen; Fernández-Carrión, Rebeca; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2018)There is growing interest in relating taste perception to diet and healthy aging. However, there is still limited information on the influence of age, sex and genetics on taste acuity as well as on the relationship between ... -
Candidate Gene and Genome-Wide Association Studies for Circulating Leptin Levels Reveal Population and Sex-Specific Associations in High Cardiovascular Risk Mediterranean Subjects
CAROLINA, ORTEGA-AZORÍN; Coltell, Oscar; Asensio, Eva Maria; Sorlí, José V; González, José I.; Portolés, Olga; Saiz, Carmen; Estruch, Ramon; Ramírez-Sabio, Judith B.; Pérez-Fidalgo, J. Alejandro; Ordovas, Jose; Corella, Dolores MDPI (2019)Leptin is a hormone crucial in the regulation of food intake and body-weight maintenance. However, the genes and gene variants that influence its plasma levels are still not well known. Results of studies investigating ... -
Circulating adiponectin and Its association with metabolic traits and Type 2 Diabetes: gene-diet interactions focusing on selected gene variants and at the genome-wide level in high-cardiovascular risk mediterranean subjects
Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Portolés, Olga; Asensio, Eva Maria; Saiz, Carmen; Barragán-Arnal, Rocío; Estruch, Ramon; Corella, Dolores MDPI (2021-02-07)Adiponectin is gaining renewed interest since, in addition to its possible protective role against insulin resistance and arteriosclerosis, recent studies suggest other additional favorable effects. However, the influence ... -
CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial
Corella, Dolores; Asensio, Eva Maria; Coltell, Oscar; Sorlí, José V; Estruch, Ramon; Martínez González, Miguel Ángel; Castañer, Olga; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Gómez Gracia, Enrique; CAROLINA, ORTEGA-AZORÍN; Fiol Ramis, Miquel; Díez Espino, Javier; Díaz López, Andrés; Fitó, Montserrat; Ros, Emilio; Ordovás Muñoz, José M. BioMed Central (2016-01)Background Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by ... -
Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial
Martínez González, Miguel Ángel; Buil-Cosiales, Pilar; Corella, Dolores; Bulló, Mònica; Fitó, Montserrat; Vioque, Jesus; Romaguera, Dora; Martínez, J. Alfredo; Wärnberg, Julia; López Miranda, José; Estruch, Ramon; Bueno Cavanillas, Aurora; Arós, Fernando; Tur, Josep; Tinahones Madueño, Francisco José; Serra-Majem, Lluis; Martín, Vicente; Lapetra, José; Vázquez, Clotilde; Pintó, Xavier; Vidal, Josep; Daimiel-Ruiz, Lidia Ángeles; Delgado Rodríguez, Miguel; Matía, Pilar; Ros, Emilio; Fernández Aranda, Fernando; Botella, Cristina; Puy Portillo-Baquedano, María; Lamuela Raventós, Rosa María; Marcos, Ascensión; Sáez, Guillermo; Gómez-Gracia, Enrique; Ruiz-Canela, Miguel; Toledo, Estefanía; Alvarez-Alvarez, Ismael; Díez Espino, Javier; Sorlí, José V; Basora, Josep; Castañer, Olga; Schröder, Helmut; Navarrete-Muñoz, Eva María; Zulet, M. Angeles; García-Rios, Antonio; Salas-Salvadó, Jordi Oxford University Press (2019-04)The PREDIMED (in Spanish: PREvención con DIeta MEDiterránea) primary prevention trial1–3 reported in 2013 that long-term adherence to an energy-unrestricted Mediterranean diet (MedDiet), supplemented with either extra-virgin ... -
Crosstalk between smoking and the genome in older subjects with metabolic syndrome through genomics, epigenomics and transcriptomics
Coltell, Oscar; Asensio, Eva Maria; CAROLINA, ORTEGA-AZORÍN; Barragán-Arnal, Rocío; Sáiz, Carmen; Portolés, Olga; Sorlí, José V; Corella, Dolores European Molecular Biology Organization (EMBO) (2019-09-11)Tobacco smoking (Figure 1) is a major cause of cardiovascular diseases (CVD), and appears to have a multiplicative interaction with the other major CVD risk factors (lipids, hypertension, diabetes and others present in the ... -
Dietary alpha-Linolenic Acid, Marine omega-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study
Sala-Vila, Aleix; Guash-Ferré, Marta; Hu, Frank B.; Sánchez-Tainta, Ana; Bulló, Mònica; Serra-Mir, Mercè; López-Sabater, Maria Carmen; Sorlí, José V; Arós, Fernando; Fiol Ramis, Miquel; Muñoz, Miguel Ángel; Serra-Majem, Lluis; Martínez, J. Alfredo; Corella, Dolores; Fitó, Montserrat; Salas-Salvadó, Jordi; Martínez González, Miguel Ángel; Estruch, Ramon; Ros, Emilio; Coltell, Oscar; PREDIMED Investigators American Heart Association (2016-01)Background Epidemiological evidence suggests a cardioprotective role of α‐linolenic acid (ALA), a plant‐derived ω‐3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω‐3 fatty acids (long‐chain ... -
Education modulates the association of the FTO rs9939609 polymorphism with body mass index and obesity risk in the Mediterranean population
Corella, Dolores; Carrasco, Paula; Sorlí, José V; Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Guillen, Montserrat; González, José I.; Sáiz, Carmen; Estruch, Ramon; Ordovás Muñoz, José M. Elsevier (2012)Objective To define whether the rs9939609 FTO (fat mass and obesity associated) single nucleotide polymorphism (SNP) is associated with anthropometric measurements and its modulation by educational level in a Mediterranean ...