Listar por tema "Ethanol"
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PPAR-α L162V and PGC-1 G482S gene polymorphisms, but not PPAR-γ P12A, are associated with alcohol consumption in a Spanish Mediterranean population
Elsevier (2008)Background: Peroxisome Proliferator-Activated Receptors (PPARs) and its co-activators are regulatory elements of the cellular lipid homeostasis and have been associated with feeding behavior modulation. Animal models suggest ... -
Psicobiología del alcohol: Función del calcio intracelular en la activación de la proteina Kinasa A y sus consecuencias conductuales de su manipulación
Universitat Jaume I (2014-06-16)Currently, alcohol is one of the most consumed drugs worldwide. However, despite all the advances in neuroscience, mechanism of action of alcohol at a central level is still unknown. The main objective of this work is ... -
Rol del calcio en los efectos del etanol
Universitat Jaume I (2015-07-22)Alcohol is the most consumed drug worldwide and causes many deaths. Its abuse can contribute to various medical complications and lead to addiction. Although the underlying molecular mechanisms have been studied extensively ... -
Role of Corticotropin-Releasing Factor and Corticosterone in Behavioral Sensitization to Ethanol
American Society for Pharmacology and Experimental Therapeutics (2012)Neuroadaptations underlying sensitization to drugs of abuse seem to influence compulsive drug pursuit and relapse associated with addiction. Our previous data support a role for the corticotropin-releasing factor (CRF) ... -
Role of intracellular calcium on Ethano-induced activation of protein Kimase A: Molecular model and behavioral consequences
Universitat Jaume I (2018-06-27)Bibliographic review whose purpose is to try to demonstrate the mechanism of action of Ethanol . The studies focus on some molecular targets that seem to be affected by the consumption of ... -
Role of phosphodiesterase-4 on ethanol elicited locomotion and narcosis
Elsevier (2016)The cAMP signaling pathway has emerged as an important modulator of the pharmacological effects of ethanol. In this respect, the cAMP-dependent protein kinase has been shown to play an important role in the modulation of ... -
Salsolinol, posible mediador de los efectos del etanol en organismos
Universitat Jaume I (2017)El alcohol es la droga más aceptada y consumida en el mundo, la cual puede causarte un alto nivel de dependencia, a causa, principalmente, del efecto reforzante que produce en tu cerebro. En el presente trabajo nos vamos ... -
The H2O2 scavenger ebselen decreases ethanol-induced locomotor stimulation in mice
Elsevier (2012)Background In the brain, the enzyme catalase by reacting with H2O2 forms Compound I (catalase–H2O2 system), which is the main system of central ethanol metabolism to acetaldehyde. Previous research has demonstrated that ... -
The renaissance of acetaldehyde as a psychoactive compound: decades in the making
Frontiers Media (2014-07-22)As with many events in the history of science, the development of the hypothesis that acetaldehyde is a plausible psychoactive substance with specific central effects (not related to its toxic- ity) has not been either ... -
Use of illicit drugs, alcohol and tobacco in Spain and Portugal during the COVID-19 crisis in 2020 as measured by wastewater-based epidemiology
ELSEVIER (2022)The COVID-19 pandemic spread rapidly worldwide in the year 2020, which was initially restrained by drastic mobility restrictions. In this work, we investigated the use of illicit drugs (amphetamine, methamphetamine, ecstasy, ...