Listar por autoría "e75ef02c-bbb1-4558-964a-3f25101d0c56"
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¿Qué papel juega la exposición solar en el desarrollo del cáncer de piel? El efecto de la radiación ultravioleta en la acumulación de mutaciones somáticas en piel sana
Moreno Illueca, Rocío; Herrero Rodríguez, Germán; Hernando, Barbara; Martinez-Cadenas, Conrado Publicacions de la Universitat Jaume I. Servei de Comunicació i Publicacions (2020)Introducción: El cáncer cutáneo surge a resultas de alteraciones genómicas en células de la piel, normalmente a consecuencia de la exposición a radiación solar. La detección de mutaciones somáticas en células normales puede ... -
¿Qué repercusión a nivel fisiológico puede tener realizar una carrera de ultratrail? Análisis de la alteración de biomarcadores de daño cardíaco y muscular en corredores amateurs de ultratrail
Collado Andrés, Claudia; Hernando, Barbara; Hernando, Carlos; Martinez-Cadenas, Conrado Publicacions de la Universitat Jaume I. Servei de Comunicació i Publicacions (2020)La participación en ultratrails ha incrementado significativamente su popularidad en los últimos años. Debido a las características extremas de estas pruebas y a las consecuencias que pueden tener sobre la salud de ... -
Sex and MC1R variants in human pigmentation: Differences in tanning ability and sensitivity to sunlight between sexes
Hernando, Barbara; Ibarrola-Villava, Maider; Peña Chilet, María; Alonso, Santos; Ribas, Gloria; Martinez-Cadenas, Conrado Elsevier (2016) -
Sex-specific genetic effects associated with pigmentation, sensitivity to sunlight, and melanoma in a population of Spanish origin
Hernando, Barbara; Ibarrola-Villava, Maider; Fernández, Lara P.; Peña Chilet, María; Llorca-Cardeñosa, Marta J.; Oltra, Sara S.; Alonso, Santos; Boyano, Dolores; Martinez-Cadenas, Conrado; Ribas, Gloria BioMed Central (2016-03)Background Human pigmentation is a polygenic quantitative trait with high heritability. In addition to genetic factors, it has been shown that pigmentation can be modulated by oestrogens and androgens via up- or ... -
Simultaneous purifying selection on the ancestral MC1R allele and positive selection on the melanoma-risk allele V60L in South Europeans
Martinez-Cadenas, Conrado; López, Saioa; Ribas, Gloria; Flores, Carlos; García, Oscar; Sevilla, Arrate; Smith-Zubiaga, I.; Ibarrola-Villava, Maider; Pino-Yanes, M .; Gardeazabal, Jesús; Boyano, Dolores; García de Galdeano, Alicia; Izagirre, Neskuts; de la Rúa, Concepción; Alonso, Santos Oxford University Press (2013)In humans, the geographical apportionment of the coding diversity of the pigmentary locus melanocortin-1 receptor (MC1R) is, unusually, higher in Eurasians than in Africans. This atypical observation has been interpreted ... -
Sun exposure and PDZK1 genotype modulate PDZK1 gene expression in normal skin
Hernando, Barbara; Ibarrola-Villava, Maider; Oltra, Sara S.; Valcuende-Cavero, Francisca; PITARCH BORT, GERARD; Mahiques, Laura; Ribas, Gloria; Martinez-Cadenas, Conrado Wiley (2020)Human skin pigmentation results from the enzymatically controlled synthesis of melanin pigments in specialized organelles (melano‐somes) produced within epidermal melanocytes, followed by their transfer to neighboring ... -
The effect of age on the acquisition and selection of cancer driver mutations in sun-exposed normal skin
Hernando, Barbara; Dietzen, M.; Parra, G.; Gil-Barrachina, Marta; PITARCH BORT, GERARD; Mahiques, Laura; Valcuende-Cavero, Francisca; McGranahan, Nicholas; Martinez-Cadenas, Conrado Elsevier (2021)Background: The accumulation of somatic mutations contributes to ageing and cancer. Sunlight is the principal aetiological factor associated with skin cancer development. However, genetic and phenotypic factors also ... -
The Interplay between Natural Selection and Susceptibility to Melanoma on Allele 374F of SLC45A2 Gene in a South European Population
López, Saioa; García, Oscar; Yurrebaso, Iñaki; Flores, Carlos; Acosta-Herrera, Marialbert; Chen, Hua; Gardeazabal, Jesús; Careaga, Jesús María; Boyano, Dolores; Sánchez, Ana; Ratón-Nieto, Juan Antonio; Sevilla, Arrate; Smith-Zubiaga, I.; García de Galdeano, Alicia; Martinez-Cadenas, Conrado; Izagirre, Neskuts; de la Rúa, Concepción; Alonso, Santos Public Library of Science (2014)We aimed to study the selective pressures interacting on SLC45A2 to investigate the interplay between selection and susceptibility to disease. Thus, we enrolled 500 volunteers from a geographically limited population ... -
Two Clinical Cases of Li-Fraumeni Syndrome and Prostate Cancer: Genetic Counseling and Clinical-Surgical Management.
Abad Carratalà, Guillem; Blanco Silvestre, Marc; Sánchez Llopis, Anna; Monsonís Usó, Rosa; Martinez-Cadenas, Conrado; Martinez Meneu, Pedro; Amaya Barroso, Bárbara; Muñoz, Elia; Garau-Perelló, Carmen; Ponce-Blasco, Paula; Barrios-Arnau, Laura; Bosquet, Manuel; RODRIGO-ALIAGA, MIGUEL Elsevier (2022-06-09)The present article treats about Li-Fraumeni syndrome (LFS), a genetic disease with autosomal dominant transmission which is associated with an increased predisposition to suffer certain cancers. However, prostate cancer ... -
UV-Induced Somatic Mutations Driving Clonal Evolution in Healthy Skin, Nevus, and Cutaneous Melanoma
Loras Monfort, Alba; Gil-Barrachina, Marta; Marques-Torrejon, Maria Angeles; Pérez-Pastor, Gemma María; Martinez-Cadenas, Conrado MDPI (2022-08-29)Introduction: Due to its aggressiveness, cutaneous melanoma (CM) is responsible for most skin cancer-related deaths worldwide. The origin of CM is closely linked to the appearance of UV-induced somatic mutations in ...