Listar por autoría "19086f55-d62d-4762-9716-963245baec9a"
Mostrando ítems 21-27 de 27
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Stereoselective synthesis of the cytotoxic macrolide aspergillide B
Diaz-Oltra, Santiago; Angulo-Pachón, César A.; Kneeteman, María N.; Murga, Juan; Carda, Miguel; Marco, J. Alberto Elsevier (2009)A total, stereoselective synthesis of the cytotoxic macrolide aspergillide B has been performed. A cross metathesis and a C-glycosidation via a Mukaiyama-type aldol reaction were key features of the synthesis. The macrocyclic ... -
Structure-performance relationships of four lysosomal markers used for the imaging of HT-29 cancer cells and a cellular model of lysosomal storage disease (Niemann-Pick C)
Navarro Barreda, Diego; Bedrina Broch, Begoña; Angulo-Pachón, César A.; Miravet, Juan; Perez-Sala, Dolores; Galindo, Francisco Elsevier (2022-03-12)Four new BODIPY derivatives with a potential tendency to aggregation have been synthesized and characterized by means of NMR techniques, mass spectrometry and UV–Vis/fluorescence spectroscopies. The objective of this study ... -
Sucrose-fueled, energy dissipative, transient formation of molecular hydrogels mediated by yeast activity
Angulo-Pachón, César A.; Miravet, Juan Royal Society of Chemistry (2016-03)A biologically mediated, energy dissipative, reversible formation of fibrillar networks is reported. The process of gelation is linked to sucrose-fueled production of CO2 by baker’s yeast (Saccharomyces cerevisiae). ... -
Synthesis and Biological Evaluation As Microtubule-Active Agents of Several Tetrahydrofuran and Spiroacetal Derivatives
Carda, Miguel; Murga, Juan; Angulo-Pachón, César A.; García Pla, Jorge; Diaz-Oltra, Santiago; Marco, J. Alberto; Trigili, Chiara; Redondo Horcajo, Mariano; Díaz, J. Fernando; Barasoain, Isabel Bentham Science (2013)The stereoselective preparation of several molecules containing structural fragments of the tetrahydrofuran and spiroacetal type is described. Their degree of cytotoxicity and their interactions with tubulin have been ... -
Synthesis and biological properties of the cytotoxic 14-membered macrolides aspergillide A and B
Diaz-Oltra, Santiago; Angulo-Pachón, César A.; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto Wiley (2010-11-09)Total, stereoselective syntheses of the naturally occurring, cytotoxic macrolides aspergillide A and B are described. Olefin metatheses and asymmetric allylations were key steps in the synthetic sequences. Cytotoxicity ... -
Synthesis of a Double-Network Supramolecular Hydrogel by Having One Network Catalyse the Formation of the Second
Singh, Nishant; Maity, Chandan; Zhang, Kai; Angulo-Pachón, César A.; van Esch, Jan; Eelkema, Rienk; Escuder, Beatriu Wiley (2017-02-10)elf-assembly of biomolecules catalytically controls the formation of natural supramolecular structures, giving highly ordered complex materials. Such desirable hybrid systems are very difficult to design and construct ... -
Tandem reactions in self-sorted catalytic molecular hydrogels
Singh, Nishant; Zhang, Kai; Angulo-Pachón, César A.; Mendes, Eduardo; van Esch, Jan; Escuder, Beatriu Royal Society of Chemistry (2016)By equipping mutually incompatible carboxylic acid and proline catalytic groups with different self-assembling motives we have achieved self-sorting of the resulting catalytic gelators, namely SucVal8 and ProValDoc, into ...