Listar por tema "dopamine"
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Hippocampal dopamine receptors modulate cFos expression in the rat nucleus accumbens evoked by chemical stimulation of the ventral hippocampus
Elsevier (2005-12)Recently, we have shown that D1 and D2 receptors in the ventral hippocampus (VH) modulate both the locomotor activation and the increase in dopamine (DA) levels in the rat nucleus accumbens (NAc) induced by NMDA stimulation ... -
Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion
Frontiers Media (2021)Impaired behavioral activation and effort-related motivational dysfunctions like fatigue and anergia are debilitating treatment-resistant symptoms of depression. Depressed people show a bias towards the selection of low ... -
Individual differences on running wheel activity: relation to anxiety parameters, spontaneous locomotion and social interaction
Universitat Jaume I (2017-06-19)Motivated behaviors are characterized by a high degree of vigor, persistence and work output, and organisms frequently make effort-related decisions based upon cost/benefit analysis. The study of individual differences in ... -
Interacción entre receptores d2 y a2a. Toma de decisiones basada en el esfuerzo mediante un Programa de Razón Progresiva en ratas
Universitat Jaume I (2015)Uno de los síntomas motivacionales característicos de la depresión y que supone un mayor problema para la realización de tareas cotidianas, es la anergia. Este síntoma supone una disminución del vigor y el esfuerzo que ... -
Lesions of the dopaminergic innervation of the nucleus accumbens medial shell delay the generation of preference for sucrose, but not of sexual pheromones
Elsevier (2012-01)Male sexual pheromones are rewarding stimuli for female mice, able to induce conditioned place preference. To test whether processing these natural reinforcing stimuli depends on the dopaminergic innervation of the nucleus ... -
Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat
MDPI (2023-03)The worldwide increase in cognitive decline, both in aging and with psychiatric disorders, warrants a search for pharmacological treatment. Although dopaminergic treatment approaches represent a major step forward, current ... -
Métodos inmunológicos para la detección de cambios en el sistema dopaminérgico: western blot y neurohistología para la detección de DARPP-32
Universitat Jaume I (2016)La detección de cambios en los niveles de un neurotransmisor, como la dopamina o de su cascada metabotrópica que se inicia con la activación de sus receptores tras la realización de una conducta o un tratamiento farmacológico ... -
Mild maternal separation in mice of both sexes: impact in adultthood on vigor to approach or to escape motivational stimuli and interaction with dopamine depletion
Universitat Jaume I (2020-07-21)Early-life stress affects brain development and can lead to psychiatric disorders such as depression later in life. Little is known about the effect of early-life stress on motivational processes such as effort-based ... -
Neurobiology of social attachments
Elsevier (2014)Many types of social attachments can be observed in nature. We discuss the neurobiology of two types (1) intraspecific (with a partner) and (2) parental (with the offspring). Stimuli related to copulation facilitate the ... -
La reducción de los niveles de dopamina no altera la conducta de «atracón de comida» en ratones, pero la cafeína modula el consumo en función de los niveles de ansiedad.
Universitat Jaume I (2016)Introducción: La conducta de «atracón» consiste en consumir, en un período breve de tiempo, más cantidad de alimentos del que se consumiría normalmente en situaciones similares y en un plazo de tiempo igual. Es una ... -
Reward sensitivity modulates brain activity in the prefrontal cortex, acc and striatum during task switching
Public Library of Science (2015)Current perspectives on cognitive control acknowledge that individual differences in motivational dispositions may modulate cognitive processes in the absence of reward contingencies. This work aimed to study the relationship ... -
Selective dopaminergic lesions of the ventral tegmental area impair preference for sucrose but not for male sexual pheromones in female mice
Wiley (2006-08)The role of the meso-accumbens dopaminergic pathway in reward-related behaviours is the subject of intense investigation. In this regard, here we analyse the effects of specific lesions of dopaminergic cells of the ventral ... -
Sex and age differences in mice models of effort-based decision-making and anergia in depression : the role of dopamine, and cerebral-dopamine-neurotrophic-factor
Springer Nature (2023-08-18)Mesolimbic dopamine (DA) regulates vigor in motivated behavior. While previous results have mainly been performed in male rodents, the present studies compared CD1 male and female mice in effort-based decision-making tests ... -
Sexual pheromones and the evolution of the reward system of the brain: The chemosensory function of the amygdala
Elsevier (2008-03)The amygdala of all tetrapod vertebrates receives direct projections from the main and accessory olfactory bulbs, and the strong similarities in the organization of these projections suggest that they have undergone a very ... -
The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond
Wiley (2012-01)For many years, it has been suggested that drugs that interfere with dopamine (DA) transmission alter the “rewarding” impact of primary reinforcers such as food. Research and theory related to the functions of mesolimbic ... -
The monoamine-oxidase B inhibitor deprenyl increases selection of high-effort activity in rats tested on a progressive ratio/chow feeding choice procedure: Implications for treating motivational dysfunctions
Elsevier (2018-04)Motivated behaviors often are characterized by a high degree of behavioral activation and work output, and organisms frequently make effort-related decisions based upon cost/benefit analyses. Moreover, people with depression ... -
The mysterious motivational functions of mesolimbic dopamine
Cell Press (2012-11)Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance ... -
The role of Mesolimbic dopamine in the maintenance of ethanol reinforcement
Universitat Jaume I (2014-07-21)Ethanol is one of the most widely used recreational drugs, but also one of the most widely abused, causing vast economic, social and personal damage. The neurobiological processes by which ethanol seeking and consumption ... -
The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: Implications for pharmacological models of parkinsonian tremor
Elsevier (2013)Tetrabenazine (TBZ) is a reversible inhibitor of vesicular monoamine storage that is used to treat Huntington’s disease. TBZ preferentially depletes striatal dopamine (DA), and patients being treated with TBZ often experience ...