Listar por autoría "ed389880-c216-4463-9772-1f8a16e14428"
Mostrando ítems 1-20 de 24
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AuNP−polymeric ionic liquid composite multicatalytic nanoreactors for one-pot cascade reactions
Montolio Breva, Silvia; Vicent Barrera, Cristian; Aseyev, Vladimir; Alfonso Rodríguez, Ignacio; Burguete, M. Isabel; Tenhu, Heikki; Garcia-Verdugo, Eduardo; Luis, Santiago V. American Chemical Society (2016)Different AuNP-PIL nanocomposites have been developed as bifunctional catalysts in which the IL-like units promote the Knoevenagel condensation through a dual electrophilic/nucleophilic activation relay mechanism and ... -
Bioinspired Chemistry Based on Minimalistic Pseudopeptides
Luis, Santiago V.; Alfonso Rodríguez, Ignacio ACS Publications (2014)For years researchers have tried to understand the molecular behavior of complex biomolecules through the development of small molecules that can partially mimic their function. Now researchers are implementing the reverse ... -
Chiral Imidazolium Receptors for Citrate and Malate: The Importance of the Preorganization
Faggi, Enrico; Porcar Garcia, Raul; Bolte, Michael; Luis, Santiago V.; Garcia-Verdugo, Eduardo; Alfonso Rodríguez, Ignacio American Chemical Society (2014-09)A family of simple receptors formed by two or three cationic imidazolium arms attached to a central aromatic linkage and displaying different conformational flexibility has been synthesized from the enantiopure ... -
Chiral Triazolium Salts and Ionic Liquids: From the Molecular Design Vectors to Their Physical Properties through Specific Supramolecular Interactions
Luis, Santiago V.; Porcar Garcia, Raul; Ríos-Lombardía, Nicolás; Busto, Eduardo; Gotor Fernández, Vicente; Montejo Bernardo, José; Garcia-Granda, Santiago; Luis, Santiago V.; Gotor Fernández, Vicente; Alfonso Rodríguez, Ignacio; Garcia-Verdugo, Eduardo Wiley-VCH (2012-11-29)An exhaustive experimental study based on X-ray diffraction analysis, NMR, FTIR-ATR (attenuated total reflection), and Raman spectroscopy as well as theoretical calculations is reported in order to understand how the ... -
Crystal structure of the N-benzyloxycarbonyl-Alanyl- Phenylalanyl-methyl ester: the importance of the H-bonding pattern
Alfonso Rodríguez, Ignacio; Bolte, Michael; Burguete, M. Isabel; Luis, Santiago V. MDPI (2011-08-22)Large crystals of the methyl ester of the N-α-benzyloxycarbonyl protected Ala- Phe dipeptide (Z-AF-OMe) were obtained after the very slow evaporation of a solution of the corresponding carboxylic acid (Z-AF-OH) in methanol ... -
Crystal structures of the HCl salts of pseudopeptidic macrocycles display ‘‘knobs into holes’’ hydrophobic interactions between aliphatic side chains
Alfonso Rodríguez, Ignacio; Bolte, Michael; Bru Roig, Miriam; Burguete, M. Isabel; Luis, Santiago V. Royal Society of Chemistry (2009)The crystal structures of three HCl salts of pseudopeptidic macrocycles show a H-bonding tubular stack of the rings, where the amino acidic side chains (Val, Leu, Ile) display an inter-columnar “knobs into holes” hydrophobic ... -
Designed folding of pseudopeptides: the transformation of a configurationally driven preorganization into a stereoselective multicomponent macrocyclization
Alfonso Rodríguez, Ignacio; Bolte, Michael; Bru Roig, Miriam; Burguete, M. Isabel; Luis, Santiago V. VCH Verlagsgesellschaf (2008)The efficient synthesis of large-ring pseudopeptidic macrocycles through a multicomponent [2+2] reductive amination reaction is described. The reaction was entirely governed by the structural information contained in the ... -
Efficient Synthesis of Pseudopeptidic Molecular Cages
Moure, Alejandra; Luis, Santiago V.; Alfonso Rodríguez, Ignacio Wiley (2012-04)Pseudopeptidic cages have been efficiently prepared by combining a dynamic covalent procedure with the suitable preorganization of the building blocks by a conformational bias or an anion templation. -
Enantiopure triazolium salts. Chemoenzymatic synthesis and applications in organocatalysis
Luis, Santiago V.; Garcia-Verdugo, Eduardo; Ríos-Lombardía, Nicolás; Porcar Garcia, Raul; Busto, Eduardo; Alfonso Rodríguez, Ignacio; Montejo Bernardo, José; Garcia-Granda, Santiago; Gotor Fernández, Vicente Wiley-VCH Verlag GmbH & Co. KGaA (2011-10-14)A novel family of triazolium salt enantiomers has been efficiently synthesized by combining chemical and biocatalytic methods. The stereoselective action shown by hydrolytic enzymes led to the design of simple and general ... -
From Salts to Ionic Liquids by Systematic Structural Modifications: A Rational Approach Towards the Efficient Modular Synthesis of Enantiopure Imidazolium Salts
Ríos-Lombardía, Nicolás; Busto, Eduardo; Gotor Fernández, Vicente; Porcar Garcia, Raul; Garcia-Verdugo, Eduardo; Luis, Santiago V.; Alfonso Rodríguez, Ignacio; Garcia-Granda, Santiago; Menéndez Velázquez, Amador Wiley-VCH (2010)This paper reports a simple and robust modular synthetic strategy that leads to a large variety of configurationally and structurally diverse imidazole-based chiral ionic liquids (CILs) by lipase-catalyzed resolution. The ... -
Highly stable oil-in-water emulsions with a gemini amphiphilic pseudopeptide
Lotfallah, Ahmed H.; Burguete, M. Isabel; Alfonso Rodríguez, Ignacio; Luis, Santiago V. (2015-04)A gemini amphiphilic pseudopeptide promotes the spontaneous formation of an oil-in-water emulsion with a high thermal, mechanical and acid-medium stability. The micro-droplets thus formed are disassembled by strong bases ... -
Interplay between hydrophilic and hydrophobic interactions in the self-assembly of a gemini amphiphilic pseudopeptide: from nano-spheres to hydrogels
RUBIO-MAGNIETO, JENIFER; Alfonso Rodríguez, Ignacio; Burguete, M. Isabel; Luis, Santiago V. The Royal Society of Chemistry (2012-02)The formation of soluble nano-spheres or stable hydrogels through the self-assembling of a simple gemini amphiphilic pseudopeptide can be controlled by the tuning of the hydrophilic/hydrophobic interactions in aqueous medium. -
Minimalistic amino amides as models to study N–Hπ interactions and their implication in the side chain folding of pseudopeptidic molecules
Faggi, Enrico; Luis, Santiago V.; Alfonso Rodríguez, Ignacio Royal Society of Chemistry (2013)The structural study of simple amino amides derived from natural amino acids showed a unique conformational pattern for the aromatic residues, being clearly different from that for the aliphatic derivatives. The results ... -
Molecular recognition of N-protected dipeptides by pseudopeptidic macrocycles: a comparative study of the supramolecular complexes by ESI-MS and NMR
Alfonso Rodríguez, Ignacio; Bolte, Michael; Burguete, M. Isabel; Bru Roig, Miriam; Luis, Santiago V.; Vicent Barrera, Cristian Royal Society of Chemistry (2010)The molecular recognition properties of pseudopeptidic macrocycles have been studied by ESI-MS and NMR spectroscopy, as highly complementary experimental techniques in solution and in the gas phase. We used ESI-MS competition ... -
Pseudopeptidic Cages as Receptors for N-Protected Dipeptides
Faggi, Enrico; Moure, Alejandra; Bolte, Michael; Vicent Barrera, Cristian; Luis, Santiago V.; Alfonso Rodríguez, Ignacio American Chemical Society (2014-04)The molecular recognition of short peptides is a challenge in supramolecular chemistry, and the use of peptide-like cage receptors represents a promising approach. Here we report the synthesis and characterization of a ... -
Pseudopeptidic fluorescent on-off pH sensor based on pyrene excimer emission: Imaging of acidic cellular organelles
Faggi, Enrico; Serra-Vinardell, Jenny; Pandey, Mrituanjay D.; Casas, Josefina; Fabriàs, Gemma; Luis, Santiago V.; Alfonso Rodríguez, Ignacio Elsevier (2016)A pseudopeptidic compound comprising a central C2 symmetric bis(aminoamide) moiety derived from the amino acid serine and two pyrene groups at the ends, Et(SerPyr)2, has been efficiently prepared. In aqueous solution, it ... -
Stereoselective recognition of the Ac-Glu-Tyr-OH dipeptide by pseudopeptidic cages
Faggi, Enrico; Vicent Barrera, Cristian; Luis, Santiago V.; Alfonso Rodríguez, Ignacio Royal Society of Chemistry (2015)Pseudopeptidic molecular cages are appealing receptors since they can display different polar and nonpolar interaction sites in a modular framework and a controlled disposition. Inspired by previous host– guest knowledge, ... -
Stimulus responsive self-assembly of Gemini Amphiphilic Pseudopeptides
RUBIO-MAGNIETO, JENIFER; Alfonso Rodríguez, Ignacio; Burguete, M. Isabel; Luis, Santiago V. Royal Society of Chemistry (2011)Amphiphilic amino acid derived compounds are very interesting for the design of building blocks able to self-assemble into highly ordered nanostructures, in a hierarchical and controlled fashion. With this aim, the modular ... -
Structural diversity in the self-assembly of pseudopeptidic macrocycles
Alfonso Rodríguez, Ignacio; Bru Roig, Miriam; Burguete, M. Isabel; Garcia-Verdugo, Eduardo; Luis, Santiago V. Wiley-VCH (2010)The self-assembling abilities of several pseudopeptidic macrocycles have been thoroughly studied both in the solid (SEM, TEM, FTIR) and in solution (NMR, UV, CD, FTIR) states. Detailed microscopy revealed large differences ... -
Structurally disfavoured pseudopeptidic macrocycles through anion templation
Bru Roig, Miriam; Alfonso Rodríguez, Ignacio; Bolte, Michael; Burguete, M. Isabel; Luis, Santiago V. Royal Society of Chemistry (2010-08-23)An anionic dicarboxylate is able to template the formation of geometrically disfavoured macrocycles from a dynamic covalent mixture of open chain oligoimines.